Author Topic: ppa from propenylbenzenes: on using methylstyrene  (Read 820 times)

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Vaaguh

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ppa from propenylbenzenes: on using methylstyrene
« on: December 18, 2002, 04:14:00 PM »
To my best knowledge propenylbenzene is also named methylstyrene, is methylstyrene (mixture of 3- and 4- isomer) the correct reagent to be used for the synthesis of Phenylpropanolamine?

Rhodium

  • Guest
Methylstyrene doesn't come in any 3- or ...
« Reply #1 on: December 18, 2002, 05:06:00 PM »
Methylstyrene doesn't come in any 3- or 4-isomers.

beta-Methylstyrene is the same thing as Propenylbenzene, and this in turn comes in cis- and trans-form, any which is good for PPA synthesis.

alpha-Methylstyrene is another thing altogether, and cannot be used.

Vaaguh

  • Guest
from the merck catalogue:
« Reply #2 on: December 18, 2002, 05:55:00 PM »
METHYLSTYRENE (MIXTURE OF 3-AND 4-ISOMER   MERC8.22098.1000

This is directly copied from a merck catalogue, is it correct to asume this reagent is of no use for the synthesis of PPA ?


terbium

  • Guest
Methyl on the ring.
« Reply #3 on: December 18, 2002, 07:27:00 PM »
is it correct to asume this reagent is of no use for the synthesis of PPA ?
That would seem to be a correct assumption.


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