Author Topic: AL (Phikal #2)  (Read 579 times)

0 Members and 1 Guest are viewing this topic.

tryin

  • Guest
AL (Phikal #2)
« on: March 21, 2004, 07:05:00 AM »
Has anyone tried to synth AL (Phikal #2)? It seems to me that the most difficult part would be:

"A suspension of 4.0 g LAH in 150 mL anhydrous THF under N2 was cooled to 0 °C and vigorously stirred"

Is there an alternative to this step? The chemicals are very toxic, and hard to acquire. Any help is much appreciated.

hypo

  • Guest
utfse!
« Reply #1 on: March 21, 2004, 11:42:00 AM »
if you have to ask, then it is probably too hard for you.

what you need is a route to syringaldehyde (utfse) or buy it,
then alkylate (utfse) it with allyl iodide or bromide (utfse),
then do a nitromethane condensation (utfse) also called henry
reaction (utfse) and then do one of the various nitrostyrene
(utfse) reductions, for example with Zn (utfse) or Al/Hg and
NaBH4 (utfse). and then pray that the allylic double bond is
not reduced.

honestly: start with something more simple where the aldehydes
are more readily available (2C-B (utfse), Mescaline (utfse))

;)  ;)


ning

  • Guest
Actually
« Reply #2 on: April 17, 2004, 07:01:00 AM »
I'm not so sure, hypo...

If ning were to make something like that, (mind ye, mescaline is something special) the fact of the matter is, allyl chloride/bromide may just bee easier for our bee here to make than methyl iodide or whatever s/he would use to make 3,4,5-TMB. And though I'm not so sure 'bout it, last I heard allyls were pretty tough buggers, and if something harsh as hell like LiAlH4 wouldn't touch it, I bet not much else our bee would throw at it would either.

Tryin, consider using EtBr as well. That's REALLY otc.


hypo

  • Guest
?
« Reply #3 on: April 17, 2004, 09:28:00 AM »
my point was that the aldehydes for mescaline and 2c-b can be bought.
you are right about the allyl chain though - will probably survive.