Author Topic: A possible new pathway for ICE  (Read 9973 times)

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A possible new pathway for ICE
« on: October 07, 2001, 09:41:00 PM »
I've UTFSE and seen that there are some post talking 'bout ICE produced by urea and something else. I've mumbled this, from P1P alpha-halogenated and urea.

I'll look for refs for every single steps....

For now, what do you think about this? Have anyone any idea for the reduction in the last step?


  • Guest
Re: A possible new pathway for ICE
« Reply #1 on: October 08, 2001, 06:30:00 PM »
I've found some refs for ICE and a route like this:

On Beilstein (BRN 149933) there are 5 type of reactions; I've found that on Yakugaku Zasshi (a Japanese journal of pharmacological chemistry), (1948), 68, 70 it is possible make ICE from 1,2-dibromo-1-phenylpropane (from propenylbenzene!) and urea.

Other refs are:

on the same journal, (1978), 98(5), 611-617;
Heterocycles, (1997), 6(9-10), 1604-9
Berichte, (1931), 64, 1076-86 (in german!)
J. Med. Chem., (1963), 6, 266-72 (with CNBr, usual route)

On Chemical Abstract:

93:220636x --> Eur. J. Med. Chem. - Chem. Ther., (1980), 15(2), 111-17 (also this in german)

Unfortunately I cant achieve these refs and I dont know gernan, so I someone could please help me...  ;)


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1-Phenyl-1,2-Dibromopropane + Urea -> 4-MAR
« Reply #2 on: October 21, 2004, 07:53:00 PM »
Here's the CA entry from the abovementioned article which supposedly would tell us how to go from 1-phenyl-1,2-dibromopropane to 4-MAR with urea, but unfortunately it seems like this short abstract is incomplete. But nevertheless, it still contained some interesting information about ephedrine-relaed chemistry.