Author Topic: safrole > epoxide > MDP2P  (Read 989 times)

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3base

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safrole > epoxide > MDP2P
« on: June 01, 2002, 01:54:00 PM »
"Synthesis of (3,4-methylenedioxyphenyl)-2-propanone."

Xiao, Guo-min; Gu, Hai-ming; Zhang, Jin (Department of Chemistry
and Chemical Engineering, Southeast University, Nanjing 210096,
Peop. Rep. China).  Jingxi Huagong, 18(6), 321-324 (Chinese) 2001
Jingxi Huagong Bianjibu.  CODEN: JIHUFJ.  ISSN: 1003-5214.
DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology))

A process for the prepn. of (3,4-methylenedioxyphenyl)-2-propanone
was studied by means of epoxidn. of safrole and subsequent catalytic
isomerization of the so-obtained epoxide.
(3,4-Methylenedioxyphenyl)-2-propanone is a useful intermediate for
the synthesis of methyldopa, an important antihypertensive agent.
The optimal result was obtained by expts. done under various
conditions, such as kind of catalyst, consumption of catalyst and
reaction time.  The yield of epoxidn. achieved 92% at
n(catalyst):n(safrole) = 0.0039, n(catalyst):n(H2O2) = 0.0046,
n(H2O2):n(safrole) = 0.87, reaction time 4 h, reaction temp.356-358K
and with 1,2-dichloroethane as solvent. The yield of isomerization
achieved 91% at n(LiI):n(crude product) = 0.045, reaction time 6 h,
reaction temp. 351-353 K, with Et acetate as solvent and LiI as
catalyst. Purity of the title compd. was over 95%.


"Whatever there is to learn has to be learned the hard way."
Castaneda's teacher Don Juan Matus

Chromic

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Epoxidation catalyst?
« Reply #1 on: June 01, 2002, 07:29:00 PM »
What epoxidation catalyst was used?

GoiterJoe, read Jingxi Huagong, 18(6), 321-324. (unfortunately it's in Chinese)

alchemy_bee

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Where could i find thie article, i would like to ...
« Reply #2 on: June 14, 2002, 04:50:00 AM »
Where could i find this article, i would like to see it as im sure we all would. I sounds alot like

https://www.thevespiary.org/rhodium/Rhodium/chemistry/guest.phenylacetone.txt



Jingxi Huagong means "fine chemicals", this is apparently the name of the publication it comes from. Its ISSN # is 1003-5214, where should one look to find it?




I dont take drugs to be happy...
I do because they remind me that I am happy

mellow

  • Guest
You mean How do we translate this!
« Reply #3 on: July 03, 2002, 04:10:00 PM »
I'm sure everyone here has a pile of Japanese and Chinese articles they'd like translated. I do.

Maybe you could write to the original authors (in English) at their institutes for details of what they did - many scientists around the world have a smattering of English.

I'll look it up anyway. But forget about the translation - I wouldn't know where or how to start.

What about a translation commerical serivce? What are the current rates per page?