Author Topic: One-Step DMT Synthesis -Wizard X  (Read 1107 times)

0 Members and 1 Guest are viewing this topic.

dormouse

  • Guest
One-Step DMT Synthesis -Wizard X
« on: April 19, 2000, 04:47:00 PM »

   the Hive BB
  Serious Chemistry Forum
  One-Step DMT Synthesis
  
profile | register | preferences | faq | search
 
 next newest topic | next oldest topic 
Author  Topic:   One-Step DMT Synthesis 
Wizard X
Moderator   posted 05-18-99 10:57 PM          
--------------------------------------------------------------------------------
Cyclisation reaction involving nitro- and nitroso- groups with tervalent phosphorus compounds.
Reaction is :
(2-NO2)C6H4-C(CH2CH2N(CH3)2)=CH2

=============== (C2H5O)3P ==============>>>

DMT 58 %

2-Nitrostyrene : (NO2)C6H4-CH=CH2
Reaction is :
(NO2)C6H4-CH=CH2

=============== (C2H5O)3P ==============>>>
Indole

Reference ???? must find it again in my archives.

Rhodium : Can you Email me with a password for the Tryptamine forum, thanks.


Rhodium
Administrator   posted 05-19-99 08:32 PM          
--------------------------------------------------------------------------------
There is no access to the local tryptamine forum for anyone, it is just a link to the discussion board at dmt.lycaeum.org
And PLEASE do find the ref.

How is this (2-NO2)C6H4-C(CH2CH2N(CH3)2)=CH2 synthesized? I find it pretty hard to attach that =CH2 on the benzylic carbon...


Wizard X
Moderator   posted 05-20-99 10:55 PM          
--------------------------------------------------------------------------------
2HC=C(2-NO2C6H4)-CH2CH2N(CH3)2
2-(2-nitrophenyl)-4-dimethylamine butene
A good starting compound would be :
2-nitrocinnamic aldehyde.
REF's Tervalent phosphorous reagents.
[reducing agents]
Quart. Rev. , Vol 16, pg 208 (1962)

[reduction of -NO and -NO2]
Quart. Rev. , Vol 22, pg 222 (1968)

[Deoxygenation reactions : Cyclisation]
Chem. Soc. Rev. , Vol 3, pg 87 (1974)