Author Topic: LSD from LSA synth qeustion  (Read 2810 times)

0 Members and 1 Guest are viewing this topic.

flipper

  • Guest
LSD from LSA synth qeustion
« on: December 16, 2002, 06:15:00 PM »
What's against this synth which is high yielding and easy?

(don't know the reference)

13,4 g dry LSA in 800 ml of DMF in a vacuüm flask @ 20°C, you add a solution of N,N-Carbonyldiimidazole in 250 ml of DMF. Stir for one half hour @ 20°C in the dark.
Add after that a solution of 4 g DEA in 50 ml of DMF.
Let stand for 2 hours @ 20°C and then 20 hours @ 5°C.
Evaporate in vacuüm to get the LSD.
Disolve in 2,5 L of 2% tartaric acid. Extract with Ether and discard Ether. Filter and basify with NH4OH and extract with a 9:1 ether:ethanol solution. Dry and evaporate in vacuüm to get LSD in 81% yield.



raffike

  • Guest
Dunno if it works but Carbonyldiimidazole is ...
« Reply #1 on: December 16, 2002, 06:21:00 PM »
Dunno if it works but Carbonyldiimidazole is pretty cheap @ Fluka.

For those about to synth,we salute you

Rhodium

  • Guest
Carbonyldiimidazole is a well-known amide forming ...
« Reply #2 on: December 16, 2002, 08:16:00 PM »
Carbonyldiimidazole is a well-known amide forming agent, so it seems just fine. You do need a pretty hefty vacuum to be able to evaporate DMF at room temp (or slightly above) though.

PoohBearium

  • Guest
DEA?
« Reply #3 on: December 16, 2002, 08:47:00 PM »

Add after that a solution of 4 g DEA...




Heh, that's funny.  Must be diethylamide, right?

PB


Cocaine isn't habit forming. I should know - I've been using it for years.

Tallulah Bankhead

Rhodium

  • Guest
Close
« Reply #4 on: December 16, 2002, 08:54:00 PM »
Almost, it's diethylamine, (C2H5)2NH.

PoohBearium

  • Guest
Aight
« Reply #5 on: December 17, 2002, 12:02:00 AM »
I did second guess myself with it being an amine, but I went with the amide because of the "lysergic acid diethylamide" name.  Looks like a pretty simple molecule...

Is this the much sought after practical LSD wonder-synth?

:)

PB

*Can't wait to take gen chem 2 (will be analytical work, mostly), though I fear I have already forgotten most of what I knew about chemistry...   :(  

Cocaine isn't habit forming. I should know - I've been using it for years.

Tallulah Bankhead

cHiLLy

  • Guest
alight
« Reply #6 on: December 17, 2002, 12:11:00 AM »
I had never heard CDI (N,N-Carbonyldiimidazole) being mentioned as a coupling reagent for L synth. That does seem very simple!
Heres another peptide coupling reagent that ive never heard discussed...1-Hydroxy-7-azabenzotriazole, HOAT. any possibilities there?

Lilienthal

  • Guest
e.g. UTFSE :-)
« Reply #7 on: December 17, 2002, 01:59:00 PM »
e.g. UTFSE  :)

Dexter666

  • Guest
Wow!
« Reply #8 on: December 21, 2002, 09:10:00 AM »
Ok, so this is a valid synth from LSA to LSD using simple methods like mixing and stirring?

Just say NO to police searches!

Rhodium

  • Guest
No, the procedure is far from complete, lacking ...
« Reply #9 on: December 21, 2002, 02:05:00 PM »
No, the procedure is far from complete, lacking every possible detail about the mandatory chromatographic purification, as well as the need to perform large parts of the synthesis under darkroom conditions, LSD being very light sensitive, especially in solution.

cHiLLy

  • Guest
Im sure that theres other obstacles..
« Reply #10 on: December 22, 2002, 08:14:00 AM »
Im sure that theres other obstacles..unfortunately theres very few first hand reports to go on. Like he said theres the chromatography and of course getting LSA is not easy either.
BTw, wasnt it determined around here that the photodecomposition isnt as considerable with large amounts?

tryptych

  • Guest
purification
« Reply #11 on: December 24, 2002, 11:06:00 PM »

PoohBearium

  • Guest
Ummm...
« Reply #12 on: December 24, 2002, 11:52:00 PM »
...toxicity?

PB

Fuck you, you bisexual midget fucking dwarf!!!

spooky1234

  • Guest
Read LSD purity on www.erowid.org.
« Reply #13 on: December 25, 2002, 08:21:00 AM »
Read LSD purity on www.erowid.org. Impurities do seem to effect the trip significantly. And iso-lsd can be converted into d-lsd easily. So there is no reason not to.

pashov

  • Guest
aminating agent?
« Reply #14 on: January 26, 2003, 01:22:00 PM »
I don't understand the role of the "aminating agent" in this synth. Why does anything need to be aminated in lysergic acid amide?

Well, I'm probably just stupid, does anybody know some references where I could read up on Carbonyldiimidazole and its use? Possibly with nice reaction diagrams and stuff...

Does somebody have references to other LSA -> LSD routes? The one on rhodium.ws looks promising, but is there anything else besides going back from LSA to lysergic acid?

flipper

  • Guest
The solvent
« Reply #15 on: February 01, 2003, 02:14:00 PM »

13,4 g dry LSA in 800 ml of DMF




Is it possible to use less solvent without effecting the yield?
Is it possible to use another solvent then DMF?