Author Topic: World's first 3D-printed drug approved by FDA  (Read 4881 times)

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Offline ijontichy

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World's first 3D-printed drug approved by FDA
« on: September 08, 2015, 03:38:27 PM »
http://www.medicalnewstoday.com/articles/297740.php

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The US Food and Drug Administration have approved the first drug that has been created using 3D printing technology, according to the drug's manufacturer Aprecia Pharmaceuticals.
SPRITAM (levetiracetam) has been approved in the form of a dissolvable pill for the treatment of seizures among people with epilepsy. By combining 3D-printing technology with a highly-prescribed epilepsy treatment, SPRITAM is designed to fill a need for patients who struggle with their current medication experience.
This is the first in a line of central nervous system products Aprecia plans to introduce as part of our commitment to transform the way patients experience taking medication.



if you can print the C O H N atoms, then you can print just about anything...

FDA Approves First 3-D Printed Pill
http://youtu.be/vi1fQ4wXjdI

3D Printing Theophylline tablet
http://youtu.be/FGpbiJxkkak

how it works
http://youtu.be/9mHnCnX4al0
« Last Edit: September 08, 2015, 03:40:58 PM by ijontichy »
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Offline Lipbalm

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Re: World's first 3D-printed drug approved by FDA
« Reply #1 on: September 08, 2015, 06:44:09 PM »
I cannnot wrap my head around how you can 'print' molecules.
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Offline Scarecrow

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Re: World's first 3D-printed drug approved by FDA
« Reply #2 on: September 08, 2015, 06:54:11 PM »
Surely this is talking about just using pre-made substances as the 3D printer substrate and its just printing it onto a pill, as opposed to printing atoms together?
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Offline ijontichy

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Re: World's first 3D-printed drug approved by FDA
« Reply #3 on: September 08, 2015, 07:18:07 PM »
https://karldcollins.wordpress.com/2012/02/28/i-hate-lee-cronin/

the inside of the 3-D printer should theoretically look like



and that blue arrows pointing to cables that transfer heat efficiently from an electrically powered stirrer hot plate (the blue thing in the bottom middle of the picture) to the chemical reaction in the flask

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Offline Lipbalm

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Re: World's first 3D-printed drug approved by FDA
« Reply #4 on: September 09, 2015, 04:13:49 AM »
I still don't get it. Now I feel old. The new generation is already making me feel dumb. I should just put myself out to pasture now.
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Offline Zippy

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Re: World's first 3D-printed drug approved by FDA
« Reply #5 on: September 09, 2015, 04:28:23 AM »
Surely this is talking about just using pre-made substances as the 3D printer substrate and its just printing it onto a pill, as opposed to printing atoms together?

That is exactly it.  They are having the drug already made in bulk and using the 3-D printer to deposit it in a pill form.  So the molecule is made by the ton somewhere in bulk and this is used to make the dosage form instead of a pill press.

Offline CHEMICALCOWBOY36

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Re: World's first 3D-printed drug approved by FDA
« Reply #6 on: September 09, 2015, 07:01:42 AM »
The real question is can you buy one or make one for a reasonably price ?
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Offline ijontichy

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Re: World's first 3D-printed drug approved by FDA
« Reply #7 on: September 09, 2015, 11:55:38 AM »
http://www.kurzweilai.net/3-d-printed-food

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For example, Lipson said, users could choose from a large online database of recipes, put a cartridge with the ingredients into their 3D printer at home, and it would create the dish just for that person. The user could customize it to include extra nutrients or replace one ingredient with another.

I don't think the drugs are premade, well maybe the 2nd generation 3-D printer does that, but the 3rd generation has already some pre-installed cartridges (small C O H N tanks) inside of it. We must access the database or the software to write the source code somehow...
« Last Edit: September 09, 2015, 11:58:03 AM by ijontichy »
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Offline ijontichy

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Re: World's first 3D-printed drug approved by FDA
« Reply #8 on: September 09, 2015, 12:37:11 PM »
http://www.care2.com/greenliving/3d-printed-drugs-to-revolutionize-prescription-medicine.html

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Instead of waiting (sometimes a day or two) to get a prescription filled, your pharmacist may soon just hand you your customized bottle of pills printed at the pharmacy. Germany-based 3D Printer Drug Machine is offering a 3D drug printer and special custom drug delivery ingredients to speed and customize the prescription drug process. The unique 3D printers are available in kit form for just $150-$300. According to an article in 3D Print, patients will have their own account in a database driven system, which allows them to order a printed drug as needed.


https://www.indiegogo.com/projects/3d-printed-customize-drug-prescription#/story

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For example, if you print a drug like an antibiotic, then we will use a certain type of polymer, Rahman explains to us. If you use an antipyretic or analgesic drug then we use anther polymer. For example, paracetamol can be used for fever, ciprofloxacin can be used as an antibiotic and other types of drug which we are now testing can be used for various diseases according to their action.


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Offline ijontichy

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Re: World's first 3D-printed drug approved by FDA
« Reply #9 on: September 09, 2015, 12:44:34 PM »
http://www.reachoutrecovery.com/the-recovery-daily/news/item/60804-what-could-the-rise-in-3d-printing-mean-for-drug-addicts

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The popularity of personal 3D printers began to rise in 2011 as prices began to fall. 3D printers typically run between $250 and $2,500 making them more readily accessible to people than ever before.

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With the growing ease of access and services available, many are questioning how the accessibility of 3D printers will affect other markets, such as illegal drugs.

One of the greatest contributing factors to the rise of prescription drug abuse is the ease of accessibility. Prescription drugs have become readily available in most households, and as a result prescription drug addiction has exploded in recent years. The increased availability of 3D printers raises similar concerns. Increased accessibility to 3D printers opens a door to even more chemical compounds without many of the associated risks. While many people are wary of interacting with a drug dealer or nervous about unknown contents in drugs, 3D printers remove many of these fears, making it easier for individuals to experiment and take risks they may have otherwise avoided.

Ease of accessibility is one of the most common contributors to initial drug use and a frequent factor in continued use. With minimal barriers, it is easier to use illicit substances and develop addiction. For many, the perception of safety also contributes to the rise in substance abuse. The ability to print drugs in the comfort of one’s home can contribute to the false belief that easy accessibility means there is no danger in use—this is similar to the phenomenon we have experience with the recent rise in Prescription drug accessibility and abuse.

Just as is the case with prescription drugs, as 3D printers become more readily available, it is important to monitor access and use. While 3D-printing drugs and prescriptions is still in its infant stages, the rapidly developing market will surely make it an everyday reality in the upcoming years.
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Offline Zippy

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Re: World's first 3D-printed drug approved by FDA
« Reply #10 on: September 09, 2015, 02:13:16 PM »
http://www.kurzweilai.net/3-d-printed-food

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For example, Lipson said, users could choose from a large online database of recipes, put a cartridge with the ingredients into their 3D printer at home, and it would create the dish just for that person. The user could customize it to include extra nutrients or replace one ingredient with another.

I don't think the drugs are premade, well maybe the 2nd generation 3-D printer does that, but the 3rd generation has already some pre-installed cartridges (small C O H N tanks) inside of it. We must access the database or the software to write the source code somehow...

The drugs are pre-made.  All this machine does is lay the drug out from a solution and dry it into a shape.  It says so right in the article.

The is no way to have a tank of C, H, N, & O.  & there never will be.   Even the Burke synthesis machine requires appropriate (and expensive) building blocks of reasonable conplexity.

Offline Scarecrow

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Re: World's first 3D-printed drug approved by FDA
« Reply #11 on: September 09, 2015, 02:24:37 PM »
Yep. There is no way it is possible, being able to program a molecule shape, and have a 3d printer build it out of C H O N P. What would be your source of atomic carbon? You would have to have sources of nucleophillic everything and also have a program that can somehow calculate the reactivity of the molecule as its being built and use different reagenets depending on the molecule lol if this is possible its far beyond anything biotech/nanotech is heading towards in the foreseeable future. Maybe once we have quantum computers and finally become buddies with our reptilian overlords
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Offline Scarecrow

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Re: World's first 3D-printed drug approved by FDA
« Reply #12 on: September 09, 2015, 02:25:22 PM »
On a good note, itd be pretty sick for us bees to make custom pills with one of these
It's a war on personal freedom, that's what it is.

Offline ijontichy

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Re: World's first 3D-printed drug approved by FDA
« Reply #13 on: September 09, 2015, 03:49:47 PM »
On a good note, it'd be pretty sick for us bees to make custom pills with one of these.

http://3dprint.com/64223/3d-printed-drugs/


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They found that when the surface area of the printed tablets were all kept constant, the drug release rates were the fastest in the pyramid shaped tablet, followed by the torus, cube, sphere, and finally the cylinder. This order is directly correlated with the tablets’ surface area/volume ratio, with the pyramid tablet having the highest value and the cylinder the lowest.



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Drug release kinetics from tablets showed no dependence on the surface area but rather on surface are to volume ratio, indicating the influence that geometrical shape has on drug release profile. Tablets of similar mass showed little difference in dissolution profiles that could be explained by the erosion-mediated process that drives the drug dissolution.

maybe a pill logo in the future...  :)
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Offline Vesp

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Re: World's first 3D-printed drug approved by FDA
« Reply #14 on: September 09, 2015, 10:12:54 PM »
Isn't that chart showing the opposite of what the text is saying?
Pyramid is slower?
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