Author Topic: DMT found naturally occuring in the brain  (Read 355 times)

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Offline Goldstein

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DMT found naturally occuring in the brain
« on: December 08, 2019, 06:28:48 PM »
Pretty cool article, researchers have discovered that DMT is biosynthesized at regular sites in the brain of rats similar to other neurotransmitters.

hxxps://www.nature.com/articles/s41598-019-45812-w

Offline carl

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Re: DMT found naturally occuring in the brain
« Reply #1 on: December 08, 2019, 07:14:47 PM »
That's not really news to me, I read that already in Tihkal?
I would suggest that you guys share information like it was the last day on Earth.  This information slowdown is all because of all that dumb unwillingness to share.  That is where the DEA is winning.  There goal is you not talking to each other.  Let the information flow.  I  promise we will always be 2 steps ahead of DEA chemists if we just keep sharing information
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Offline Goldstein

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Re: DMT found naturally occuring in the brain
« Reply #2 on: December 08, 2019, 07:52:27 PM »
That's not really news to me, I read that already in Tihkal?

Its not so much the fact its present, but where and how much that I thought was interesting.

This is important because of the levels produced as well as areas of the brain which is producing it.

The article insinuates that it is produced in amounts similar to other neurotransmitters and could be connected to other neurological/metabolic functions rather than just dreaming/ near death experiences.


Offline carl

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Re: DMT found naturally occuring in the brain
« Reply #3 on: December 08, 2019, 08:33:21 PM »
Maybe it is some sort of emulator that allows for us to convert the data set we perceive as reality?
Would explain a lot to me!
I would suggest that you guys share information like it was the last day on Earth.  This information slowdown is all because of all that dumb unwillingness to share.  That is where the DEA is winning.  There goal is you not talking to each other.  Let the information flow.  I  promise we will always be 2 steps ahead of DEA chemists if we just keep sharing information
Quote
Real bees just hear the buzzing and it doesn´t ever stop. Ever.

Offline Grud

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Re: DMT found naturally occuring in the brain
« Reply #4 on: March 27, 2020, 02:01:10 PM »
https://www.aliusresearch.org/nichols-nichols-endogenous-dmt.html

I'm not sure if i understand the last paragraph can anyone please explain and give their opinions?
« Last Edit: March 27, 2020, 02:03:24 PM by Grud »

Online aniracetam

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Re: DMT found naturally occuring in the brain
« Reply #5 on: March 27, 2020, 02:26:31 PM »
he's saying without reading the details of the study,  people who accept the alternative hypothesis would parade around falsely-claiming "we told you so" (DMT is produced in the brain).

I've read articles on the matter for 21 years, studied biochemistry, and more importantly, metabolism. To date, there has been no evidence for INMT expression in the human brain cortex, much less the pineal gland; however, it was found that DMT may be stored in neural vesicles. Since it readily diffuses across the BBB, it's more plausible that production occurs in the peripheral tissues, where INMT is expressed, and camps out in said vesicles. For what purpose, who knows.

Using logic and common sense, it wouldn't seem likely DMT production occurs in the brain, since >90% of serotonin production occurs in the gut. DMT production occurs as a side-reaction, which is not genetically preferred, after AADC (aromatic- aminoacid decarboxlase) removes the CO2, a rate-determining step. DMT production inhibits serotonin production, and vice versa, via feedback inhibition. It would seem more likely that production would occur in the gut, and surrounding tissues/epithelial cells, where INMT is known to be expressed.
« Last Edit: March 27, 2020, 02:35:21 PM by aniracetam »
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