Author Topic: is it BzP?  (Read 523 times)

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alphacentauri

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is it BzP?
« on: January 20, 2003, 07:41:00 PM »
I see from an online catalogue of chemicals supply firm this item:

Descrizione: 1-BENZILPIPERAZINA PER SINTESI ML 25
Codice:  8418020025
Produttore:  MERCK O ALTRO PRODUTTORE
Prezzo:  29.89   (i prezzi si intendono I.V.A. 20% esclusa)


Is this the famous BzP? And for synthesis? I thought it was the END of a synth process, not the BEGINNING!!!
And what is used for that stuff in synthetic chemistry?

:o

Rhodium

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BzP
« Reply #1 on: January 20, 2003, 11:22:00 PM »
Yes, that is the infamous 1-Benzylpiperazine.

In synthetic organic chemistry when you want to introduce a piperazine group somewhere, for example by reacting it with propenoic acid to get 3-(N-piperazinyl)-propanoic acid, you cannot simply mix piperazine with the acid, as it would add to both nitrogens, as the molecule is symmetric.

By instead starting with 1-Benzylpiperazine, add the acid to the free nitrogen, and finally remove the benzyl group by catalytic hydrogenolysis, the end product is 3-(N-piperazinyl)-propanoic acid without any contamination of the disubstituted analog.