Wanting to discuss this compound before bio-assay is started.
Effects from wiki
The subjective effects of 4-FA include euphoria, increased energy, mood elevation, excessive talking, bruxism (jaw clenching), insomnia and suppressed appetite.
4-Fluoroamphetamine is a potent stimulant and serotonin releaser as with other para-substituted amphetamine derivatives, but is both significantly less potent as a serotonin releaser and much less neurotoxic than related compounds such as parachloroamphetamine and paraiodoamphetamine, with both serotonin-releasing potency and neurotoxicity increasing down the halogen series 4-FA << PCA < PBA < PIA,[3][4] while conversely the dopamine reuptake inhibition produced by 4-FA is stronger than that of either PCA or PIA.[5] 4-FA also produces less hyperthermia than similar compounds such as PMA, 4-MTA and 4-methylamphetamine, but both hyperthermia and neurotoxicity are still likely to be complications of overdose or excessive use of 4-FA.
From RHODIUM
It is known that amphetamine and methamphetamine cause their stimulant effect by inducing the release of dopamine in neuron in certain regions of the brain. 4-substituted amphetamines has been shown to possess different pharmacological properties than the unsubstituted analog. It has been shown that 4-haloamphetamines in addition to their effect on dopamine also expresses serotonin-releasing effects, causing a long-term depletion of serotonin, indicating a neurotoxic effect, much like the one suggested to occur with MDMA and some of its derivatives. However, among the 4-haloamphetamines, the fluoro analog seemed to be atypical in that it did not cause any long-term changes in the brain serotonin levels, even though it was also a serotonin-releasing agent like the other 4-haloamphetamines, although weaker than the other.
Tests has showed that 4-fluoroamphetamine substitutes for amphetamine in rats, but that it does not fully substitute for the serotonergic MDMA derivative MBDB, which is the case of the other 4-haloamphetamines (which also did not substitute for amphetamine in the rats). As a conclusion, 4-fluoroamphetamine is subjectively very similar to amphetamine, but with some effect on the serotonin release, probably making the effects have a touch of MDMA-like action. Receptor interaction data suggests that racemic p-fluoroamphetamine is 2/3 as potent as d-amphetamine, probably suggesting that the racemic versions of both drugs are almost equipotent. This seems to be an interesting analog of amphetamine for use as a stimulant, and probably the yet untested 4-fluoro-methamphetamine is too. It should be easily made by reducing the nitropropene below with Fe/HOAc to give 4-Fluoro-P2P, which can be reductively aminated with methylamine to give the target compound.
Qualitative comments (Mobius):
For your information, some distant aquintance of mine tasted some p-Fluoro-Amphetamine not to long ago, motivated by a rumor that it would supposedly be much more potent than Amphetamine...
And you know what, it is slightly less potent (about 20% I would say) and is fairly different in terms of global effects... (120 mg) Slow to come on... (T + 1h) Great feeling of warmth in the face and less in the rest of the body. (T + 1.5h) Disproportionatly great feeling of euphoria compared to the stimulation (both physical and mental) felt! Funny stuff! Doesn't compare to anything he did before and, believe me this guy has eaten a lot of exotic experimental materials and he knows what he's talking about!
NB: Above 200 mg the effect become too intense to clearly perceive the difference between this compound and regular Amphetamine.
http://www.erowid.org/archive/rhodium/chemistry/pfa.spicybrown.html
Effects from wiki
The subjective effects of 4-FA include euphoria, increased energy, mood elevation, excessive talking, bruxism (jaw clenching), insomnia and suppressed appetite.
4-Fluoroamphetamine is a potent stimulant and serotonin releaser as with other para-substituted amphetamine derivatives, but is both significantly less potent as a serotonin releaser and much less neurotoxic than related compounds such as parachloroamphetamine and paraiodoamphetamine, with both serotonin-releasing potency and neurotoxicity increasing down the halogen series 4-FA << PCA < PBA < PIA,[3][4] while conversely the dopamine reuptake inhibition produced by 4-FA is stronger than that of either PCA or PIA.[5] 4-FA also produces less hyperthermia than similar compounds such as PMA, 4-MTA and 4-methylamphetamine, but both hyperthermia and neurotoxicity are still likely to be complications of overdose or excessive use of 4-FA.
From RHODIUM
It is known that amphetamine and methamphetamine cause their stimulant effect by inducing the release of dopamine in neuron in certain regions of the brain. 4-substituted amphetamines has been shown to possess different pharmacological properties than the unsubstituted analog. It has been shown that 4-haloamphetamines in addition to their effect on dopamine also expresses serotonin-releasing effects, causing a long-term depletion of serotonin, indicating a neurotoxic effect, much like the one suggested to occur with MDMA and some of its derivatives. However, among the 4-haloamphetamines, the fluoro analog seemed to be atypical in that it did not cause any long-term changes in the brain serotonin levels, even though it was also a serotonin-releasing agent like the other 4-haloamphetamines, although weaker than the other.
Tests has showed that 4-fluoroamphetamine substitutes for amphetamine in rats, but that it does not fully substitute for the serotonergic MDMA derivative MBDB, which is the case of the other 4-haloamphetamines (which also did not substitute for amphetamine in the rats). As a conclusion, 4-fluoroamphetamine is subjectively very similar to amphetamine, but with some effect on the serotonin release, probably making the effects have a touch of MDMA-like action. Receptor interaction data suggests that racemic p-fluoroamphetamine is 2/3 as potent as d-amphetamine, probably suggesting that the racemic versions of both drugs are almost equipotent. This seems to be an interesting analog of amphetamine for use as a stimulant, and probably the yet untested 4-fluoro-methamphetamine is too. It should be easily made by reducing the nitropropene below with Fe/HOAc to give 4-Fluoro-P2P, which can be reductively aminated with methylamine to give the target compound.
Qualitative comments (Mobius):
For your information, some distant aquintance of mine tasted some p-Fluoro-Amphetamine not to long ago, motivated by a rumor that it would supposedly be much more potent than Amphetamine...
And you know what, it is slightly less potent (about 20% I would say) and is fairly different in terms of global effects... (120 mg) Slow to come on... (T + 1h) Great feeling of warmth in the face and less in the rest of the body. (T + 1.5h) Disproportionatly great feeling of euphoria compared to the stimulation (both physical and mental) felt! Funny stuff! Doesn't compare to anything he did before and, believe me this guy has eaten a lot of exotic experimental materials and he knows what he's talking about!
NB: Above 200 mg the effect become too intense to clearly perceive the difference between this compound and regular Amphetamine.
http://www.erowid.org/archive/rhodium/chemistry/pfa.spicybrown.html
4-FA.pdf