Pages: 1

Author Topic: Mescaline as a mitotic spindle inhibitor.  (Read 71 times)

Vesp

  • Administrator
  • Foundress Queen
  • *****
  • Posts: 3,130
Mescaline as a mitotic spindle inhibitor.
« on: August 23, 2010, 03:47:25 AM »
http://researchlsd.blogspot.com/2008/03/mescaline-as-mitotic-spindle-inhibitor.html


I found this really interesting.
I wonder what other drugs like mescaline do the same?
Bitcoin address: 1FVrHdXJBr6Z9uhtiQKy4g7c7yHtGKjyLy

Vesp

  • Administrator
  • Foundress Queen
  • *****
  • Posts: 3,130
Re: Mescaline as a mitotic spindle inhibitor.
« Reply #1 on: September 01, 2010, 08:56:56 PM »
http://en.wikipedia.org/wiki/Oryzalin

Oryzalin can also induce polyploidy in plants much like mescaline and colchicine. Look at the structures - clearly they have some 3,4,5- similarities going on.

Oryzalin looks chemically useful IMO - It does not look that hard to bring that molecule to 3,4,5-trihydroxyphenol - or other related compounds, might be worth looking into considering it is sold in at least 40% concentrations as a herbicide.
Bitcoin address: 1FVrHdXJBr6Z9uhtiQKy4g7c7yHtGKjyLy

Naf1

  • Foundress Queen
  • *****
  • Posts: 753
Re: Mescaline as a mitotic spindle inhibitor.
« Reply #2 on: September 02, 2010, 02:02:19 AM »
It seems the tubulin binding abilities of said molecules is the most impoortant aspect, if they can effectively bind to the protein tubulin they can inhibit mitosis creating the aforementioned effect.

Quote
Tubulins are targets for anticancer drugs like Taxol and the "Vinca alkaloid" drugs such as vinblastine and vincristine. The anti-gout agent colchicine binds to tubulin and inhibits microtubule formation, arresting neutrophil motility and decreasing inflammation. The anti-fungal drug Griseofulvin targets mictotubule formation and has applications in cancer treatment.
http://en.wikipedia.org/wiki/Tubulin

Pages: 1