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Author Topic: Opioid Pharmacology  (Read 105 times)

llamabox

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Opioid Pharmacology
« on: March 25, 2009, 01:12:28 PM »
From Harvard-MIT Division of Health Sciences and Technology
Principals of Pharmacology

Vesp

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Re: Opioid Pharmacology
« Reply #1 on: March 25, 2009, 11:01:38 PM »
I really like this document, thanks for sharing it. It is very nice to have all of the information about it in relatively simple terms all in one place. Considers a lot of aspects in 13 pages. 

It even mentioned one my favorites ligands, enkephalins. I don't know why probably because enkephalinase inhibitors are common in plants, but these guys interest me.

Quote
Enkephalins include several compounds derived from a large proenkephalin molecule
(also called proenkephalin A).
• Most important compounds are pentapeptides, methionine- and leucineenkephalin.
Relatively selective ? ligands.
• Widely distributed in CNS
• Act like morphine to modulate neurotransmitter release (see p. 3)
• Found with catecholamines in sympathetic terminals and adrenal.

I've never heard of proenkephalin A before. Time to research it a bit! :D
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hypnos

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Re: Opioid Pharmacology
« Reply #2 on: October 07, 2009, 01:26:58 AM »
 enkephalins were d first opiod receptor "discovered" in1975- once again godd ole Wiki provides heaps of relevent data
  see "endorphins",,,BUT,,,, at this stage of d game--2009--you can bet there will be more to be found--interesting to note it cant pass
 d BBB until metabolised into other products
you WILL notice the use of words like "probably,,possibly,,might etc" suggesting gaps of varying degrees in the understanding
of these hormones
check out neuropharmacology--it helps show just how sophisticated our heads are!!
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