I've been staring at 4-MMC good and long and think I have a viable synthetic route.
From Propylene glycol or Tartaric acid it is an easy step to pyruvic acid.
The acid chloride can be prepared using phosgene (it's over the counter, despite its danger... it's convenient)
There is a patent that shows the friedel craft will happen para and outlines the preparation of cathinones via Friedel craft.
So, in the presence of AlCl3 A friedel craft is performed utilizing toluene.
The last step would be to form the amino group. I am uncertain whether this would be best accomplished before or after the craft addition. In the patent I found it is done prior however they utilize a protecting group, I'm reading up more on alternative protecting groups, but think it could be easier to just worry about forming the amine after.
This looks to be very straightforward. Anyone see any complications?
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6THT-48MY1K8-D&_user=10&_coverDate=06%2F06%2F2003&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1505333638&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=bfad1815454112ec57f6a71e77cb5b86&searchtype=a
"Pyruvic acid is easily prepared in 50+% yield from tartaric acid (over the counter in grocery stores) and potassium bisulfate." - Sauron (science madness)
From Propylene glycol or Tartaric acid it is an easy step to pyruvic acid.
The acid chloride can be prepared using phosgene (it's over the counter, despite its danger... it's convenient)
There is a patent that shows the friedel craft will happen para and outlines the preparation of cathinones via Friedel craft.
So, in the presence of AlCl3 A friedel craft is performed utilizing toluene.
The last step would be to form the amino group. I am uncertain whether this would be best accomplished before or after the craft addition. In the patent I found it is done prior however they utilize a protecting group, I'm reading up more on alternative protecting groups, but think it could be easier to just worry about forming the amine after.
This looks to be very straightforward. Anyone see any complications?
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6THT-48MY1K8-D&_user=10&_coverDate=06%2F06%2F2003&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1505333638&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=bfad1815454112ec57f6a71e77cb5b86&searchtype=a
"Pyruvic acid is easily prepared in 50+% yield from tartaric acid (over the counter in grocery stores) and potassium bisulfate." - Sauron (science madness)

