I'm thinking bromination of pyridine to hit the meta position(first). but that carbon cross-hair looks tricky. Anyone have any ideas ?

Interesting substance if it does that safely and reliably ..

Thats what anandamide is suposed to do . I also read that beta blockers can do the same in some cases .

http://en.wikipedia.org/wiki/Metyrapone Sounds good to me as long as it only effects the bagage that we carry with us after we have learned from it . "Metyrapone blocks cortisol synthesis" sounds good to stop the damage cortisol can do when a person goes through a load of stress too . BUT reading the rest about how Metyrapone works makes me think i would have to have a LOT more info about any possible dangers / negative effects before i would use it  ....... till then i`ll keep manipulating my anandamide receptors........

I`d like to hear more about it and the how it works if anyone has any more info ? .

Needless to say it is a possible tool that seems interesting enough to have in the tool chest .

I agree, please continue to post any finding on this compound or any similar substances. Without knowing much about its actions I would have to assume its effects are due to the blocking of cortisol meaning that stressful memories are unable to form. Very interesting approach that I have never heard of before.

I can picture something like this being used as a proactive anti PTSD given to say soldiers prior to going into battle to prevent them from forming bad memories about the battle. Still to many factors to say for sure but it does seem like it will show some effectiveness in the medical field.

Its that it messes with hormon systems that makes me wary . Them there systems and their actions are complicated . Its one thing messin with memory responses by useing cannabis to manipulate anandamide receptors getting them to do what they are suposed to do and another fucking with hormon systems . The same goes for beta blockers ....... i like my heart and through personal experience the effects of beta blockers can sometimes put the shits up me .

To put it another way . After looking at the way it works and beta blockers work i think that it would be better if scientists were allowed to experiment with manipulating anandermide receptors / system useing cannabinoids as thats what that system has been reported to be for = dealing with bad memorys . That to me means that there are less posible dangers and dangerous dangers if there are any dangers manipulating that system than hormon systems .

But i would still like to know more about the way it works and if there are any real theraputic use posibilitys . BUT ...... who ya gonna test it on ?

Anyone with Pubmed access?

Dose-dependent suppression of adrenocortical activity with metyrapone: effects on emotion and memory.

Roozendaal B, Bohus B, McGaugh JL.


Center for the Neurobiology of Learning and Memory, University of California, Irvine 92697-3800, USA.
Abstract

Different levels of circulating corticosterone are considered to produce different emotional states and effects on learning and memory. The purpose of the present study was to use different doses of the 11-beta-hydroxylase inhibitor metyrapone to produce dose-dependent inhibition of the synthesis of corticosterone and examine the consequences of that on several cognitive and emotional parameters. Systemic (SC) injections of metyrapone (25 or 50 mg/kg) dose-dependently suppressed increases in plasma concentrations of corticosterone induced by spatial training in a water maze, but did not affect plasma corticosterone levels in non-stressed rats. Treatment with the higher and lower dose of metyrapone also differentially affected behavioral measures of emotion and memory. Administration of 50 mg/kg, but not 25 mg/kg, of metyrapone impaired acquisition performance in the spatial water maze task. Both doses of metyrapone impaired retention. The impairment in retention was attenuated by dexamethasone (0.3 mg/kg) given systemically immediately after training, but not by corticosterone (0.3 mg/kg). During the exposure to a conditioned stressor of inescapable footshock, the higher, but not the lower dose of metyrapone attenuated fear-induced immobility. In contrast, the lower, but not the higher dose attenuated the anxiety state in an elevated plus-maze in a novel environment immediately after exposure to the conditioned stressor. It is suggested that emotion, learning, and memory are differentially affected by the different doses of metyrapone due to interference with different types of adrenal steroid receptors and consequent induction of various corticosterone receptor states.

PMID:
    9247987