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Author Topic: Alternative synthesis of LSD /w dehydrator agent.  (Read 246 times)

NaBH4

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Alternative synthesis of LSD /w dehydrator agent.
« on: June 10, 2011, 12:59:46 PM »
Hi, I was thinking of what Director Of Sound proposed on the topic "LSD from HBWR" and I though it was interesting.
He claimed that a solution of pure Lysergic acid in absolute ethyl alcohol gazed by anhydrous ammonia (strong ammoniac) give the Diethylamide.

Ammoniac react with absolute ethanol to form Diethylamine and the lysergic diethylamide is achieved. Indeed, there is no need to add a deydrator agent in the reaction flask because there is no water in the solution. Pure lysergic acid, pure ethanol and pure ammonia. Phosphoryl chloride seems useless in this case.

Then, i thought about it :

Pure lysergic acid cristals (anhydrous) are dissolved in chloroform. The solution is dropwise added to a solution of anhydrous diethylamine in absolute ethyl alcohol. The solution is then acidified with Sulfuric acid (PH 3), placed in fridge overnight.

The cristals are filtred out, dried.

Those cristals are dissolved in acidi methanol (acidified with tartric acid) and placed in fridge overnight. The cristals are filtred out and dried.

Yield LSD-25 in theory (i'm not sure at all).
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Sedit

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Re: Alternative synthesis of LSD /w dehydrator agent.
« Reply #1 on: June 10, 2011, 04:10:44 PM »
Show me one reference stating that NH3 in Ethanol will generate Diethylamine else I should more then likely just toss this into Vacuous post.

Think about whats being stated, your saying there is no water in the system but not even taking into consideration how Diethylamine could possibly be formed in the first place. Please do a little more research and provide some references before opening a new topic because this is seriously full of holes.
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NaBH4

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Re: Alternative synthesis of LSD /w dehydrator agent.
« Reply #2 on: June 10, 2011, 05:45:03 PM »
http://en.wikipedia.org/wiki/Diethylamine


But I was talking about using already prepared Diethylamine anhydrous in a ethyl alcohol solution, not the generation of diethylamine by the reaction of ammonia on ethanol.
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Sedit

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Re: Alternative synthesis of LSD /w dehydrator agent.
« Reply #3 on: June 10, 2011, 06:20:45 PM »
You stated,

Quote
Ammoniac react with absolute ethanol to form Diethylamine and the lysergic diethylamide is achieved. Indeed, there is no need to add a deydrator agent in the reaction flask because there is no water in the solution. Pure lysergic acid, pure ethanol and pure ammonia. Phosphoryl chloride seems useless in this case.

So you can see where the confusion is coming from. You clearly state that the ammonia reacts with Ethanol to form Diethylamine and where as this may be true under strong conditions using H2SO4 as the dehydration reagent its not going to do a damn bit of good here so one would need Diethylamine in solution.

I will doubt DOS claim of making LSD in a Bomb since its sensitive to heat I don't see any real chance for a decent yield of amide being created since amide formation from amines and carboxylic acids is a rather brute force process. One would do much better to chlorinate the carboxylic acid and react this with the amine. I would also like to hear some hard data from DOS such as the final yield after the bomb but he has not been around for a while. He posted nothing on the bomb temperature nor length of time.

If you wish to attempt it then by all means go right ahead but please don't get to attached to your Lysergic acid since you will more then likely be destroying it all in the process. He states work under red light the whole time and this is because its sensitive to heat and light yet then goes on to say fire that sucker up in a pipe bomb and BOOM LSD-25.... very unlikely.
There once were some bees and you took all there stuff!
You pissed off the wasp now enough is enough!!!

meme

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Re: Alternative synthesis of LSD /w dehydrator agent.
« Reply #4 on: July 06, 2011, 04:40:50 AM »
Um, I might believe LAA from those conditions if via the mixed anhydrides of lysergic and something else in ammoniated ethanol, not sure about the rest.

aniracetam

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Re: Alternative synthesis of LSD /w dehydrator agent.
« Reply #5 on: July 07, 2011, 07:43:18 PM »
reacting ethanol with ammonia doesn't just produce diethylamine, it also produces ethylamine and triethylamine.
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Dr.Methoxy

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Re: Alternative synthesis of LSD /w dehydrator agent.
« Reply #6 on: July 12, 2011, 10:50:19 PM »
Stop dreaming, you cannot make LSD by methods as simple as dissolving HBWR seeds into EtOH and ammonia...

The POCl3 can be replaced with another reagent such as SOCl2.

There is some methods to alkylate an amide. Some are as simple as KOH in acetone with an alkylating agent such as EtBr can give N,N-diethylamides. The problem with LSA is the acidic nitrogen of the indole. It must be protected with a TMS or any suitable protecting group. The amine can react with the EtBr, too,
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