Author Topic: o-acetyl loperamide  (Read 369 times)

tryl

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o-acetyl loperamide
« on: June 25, 2011, 10:58:18 AM »
i found some 20mg lope the other day, and my first thought of course was - o-acetyl lope!

never tried it, heard all sorts of stories, thought i'd play the guinea pig.

with some apprehension over my health and well-being, i reacted with acetyl chloride, dried, cooked, pulled into the syringe and started looking for a vein.

1/3-way, i could definitely feel opioid activity. halfway - a morphine-like rush, without the pins and needles. whole 16-17-or-so mg, whoa! who would've thought?

after the initial rush though, there's little left, at least at that dose.
i can certainly feel i am on a low-dose opioid.

definitely worth further experimentation. :)
"In the words of Archimedes, give me a lever long enough and a place to rest it... or I shall kill one hostage every hour."

The Lone Stranger

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Re: o-acetyl loperamide
« Reply #1 on: June 25, 2011, 11:33:45 AM »
Whats Lope ? I googled it and looked in wiki and cant see anything that might make someone stoned . I take it you mean loperamide ?

http://www.youtube.com/watch?v=BsDFxmbjZ7I

As far as fixing things goes please dont do it without at least doing some experiments with it first . Maybe just rub some on the inside of your forarm and see what happens , then a little on the tip of your tounge , then eat some ...... BUT when doing any of those things REMEMBER ....... start small and slowly increase the dose .

What do you mean by "a morphine-like rush, without the pins and needles" ? Clean morphine doesnt give any pins and needles and only one of the two morphines gives a rush . Mostly things junkys call rush and pins and needles are caused by impuritys and cuts . That can be seen when people talk about a heroin rush as pure heroin doesnt give a rush . With powders like that if they arent white they arent pure and even if they are they can still be full of cuts . Popular cuts are asprin and codeine and such like ...... IF a person is "lucky" .
« Last Edit: June 25, 2011, 11:37:03 AM by The Lone Stranger »

tryl

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Re: o-acetyl loperamide
« Reply #2 on: June 25, 2011, 11:47:19 AM »
yea, i was referring to loperamide.

i have tried the hcl and sulfate morphine salts and morphine base.

all 3 have this 'pins and needles' effect. :)
like an electrifying jolt throughout the body.

"In the words of Archimedes, give me a lever long enough and a place to rest it... or I shall kill one hostage every hour."

The Lone Stranger

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Re: o-acetyl loperamide
« Reply #3 on: June 25, 2011, 12:23:58 PM »
I dont want to argue but you are wrong . I`ve worked as a drug adviser , been a junkie , my friends were mostly junkies / ex-junkies and i have 40 years of experience with drugs and non of the three morphines you talk about have the effects you are talking about in me , them or any of the clients i`ve helped who used the pure products and i havent read of those effects in any of the VERY much literature i`ve read over those years  . Those products came from chemists shops and hospitals on prescription as crystals or in ampules so they were garanteed pure .

As to anyone thinking it might be a dosage question i`ve had the privaledge of haveing the whole drug safe contents from many chemists shops in piles at my feet and fixed as much and as fast as i could . That means literaly one fix after another in 2 or 3 minute takt for hours . And not useing poxy little insulin syrynges i mean 20 ml syrynges and bigger . <------ not saying that they were full though ....

The rush wich one only gets off one of the morphines has no jolt or any form of iritation its relaxing and allthough its not realy anything like an orgasm and orgasm is about the nearest description to explain what its like .  Maybe saying its like a cloud of something etherreal like the smell of aceton or some other solvents going up the vein and then one gets the same sort of cloudy ethereal taste mixed with blood in the back of the throat . IF you have had any garanteed pure morphine , by that i dont mean extracted from tablets , and you get those effects its you and not the drug .

I have heard of and had effects like you describe from unpure drugs .

I dont feel that i have anymore to add to this discussion so i wont post in it again unless i feel a real need = someone asks me direct questions or i see a need to try to keep someone safe and healthy . I wish you luck and i hope you have "fun" .
« Last Edit: June 25, 2011, 12:25:59 PM by The Lone Stranger »

tryl

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Re: o-acetyl loperamide
« Reply #4 on: June 25, 2011, 02:43:35 PM »
right.

first, english is not my native language, so this might, as is often the case, be a semantic issue.

not sure about the actual definition of a "rush", but i am too lazy right now to check it either way.

i have been an active junkie for 7 years, have come across streer-value crap as often as i have scored pharm grade stuff.

i actually began my 'carrier' with morphine hcl ampules.

there is an initial minute or two electrifying wave, on 30-40+ mg, that some find pleasant, some unpleasant. i'd say it's pleasantly unpleasant. it might even be peripheral in effect, i've no clue as to the pharmacodynamics of the opioid 'kick'. i doubt any self-respecting scientist would publish a paper on this.

anyway, i'm not here to measure my dick with anybody, i just say i've shot a lot of all these morphines and varying grade smack, even strychnine laced, and 'pure' homebake i've prepared myself. i think i can discern the effects of impurities from those of opiates.
if shot IV, both morphine and heroin have a rush, at least by my definition of a 'rush'.

but anyway.

i don't wanna argue.

and i don't care if i 'turn' being un-informed. :)
« Last Edit: June 25, 2011, 03:15:01 PM by tryl »
"In the words of Archimedes, give me a lever long enough and a place to rest it... or I shall kill one hostage every hour."

The Lone Stranger

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Re: o-acetyl loperamide
« Reply #5 on: June 25, 2011, 02:53:42 PM »
tryl ..... If it was my fault that your question thread got moved to this section i apologise . I hope that some of the people with chemistry knowledge notice the thread and answer your question / s as i am a firm believer in personal freedom and that answereing questions like yours helps people not to hurt themselves ..

"i doubt any self-respecting scientist would publish a paper on this."

The first wave of morphine addicts were mostly doctors who were serving in armys in war times in the 1800s and felt the need to get mental distance from all the mangled bodys that they were faced with . It was part of the reason for modern = since the start of the last century drug laws . As that was before todays drug war there was / are a lot of very full and competent reports about the use and effects of morphine .

tryl

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Re: o-acetyl loperamide
« Reply #6 on: June 25, 2011, 04:43:18 PM »
no man, all is good. :)
"In the words of Archimedes, give me a lever long enough and a place to rest it... or I shall kill one hostage every hour."

tryl

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Re: o-acetyl loperamide
« Reply #7 on: June 25, 2011, 04:43:59 PM »
and i also need that fix to distance myself mentally from my daily life, so i can well understand the dudes, haha.
"In the words of Archimedes, give me a lever long enough and a place to rest it... or I shall kill one hostage every hour."

The Lone Stranger

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Re: o-acetyl loperamide
« Reply #8 on: June 25, 2011, 08:55:41 PM »
"and i also need that fix to distance myself mentally from my daily life"

Yup .... me to ..... i just noticed you didnt ask a question and that the thread is now in the right section  = i was mistaken in what i said about that   ....... .a nice big fat bag of morphine would do me good .
« Last Edit: June 25, 2011, 09:52:16 PM by The Lone Stranger »

jon

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Re: o-acetyl loperamide
« Reply #9 on: June 26, 2011, 01:52:16 AM »
you really need to try the propyl ester it's 5 times stronger than that.
and, there is no ortho phenol so there can't be any ortho ester.
it has less sedation than other opiates the pins and needles i never got that but,
with morphine your limbs feel heavy with this the body feels almost weightless like there is no sensation.
the euphoria is distinct because there is less sedation or nod effect more of a euphoria coupled with relaxation i never got any dysphoria from it.
definitely is something to this stuff.
somewhere into the 150-200 milligram you start getting blurry vision and see double.
that happens when you overdose it's a sign of respiratory depression.
« Last Edit: June 26, 2011, 05:47:23 AM by jon »

tryl

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Re: o-acetyl loperamide
« Reply #10 on: June 26, 2011, 07:52:21 AM »
yea, i gotta get me some propionic anhydride, i wanna make dipropanoylmorphine too, it's supposedly more potent than H.
"In the words of Archimedes, give me a lever long enough and a place to rest it... or I shall kill one hostage every hour."

Sedit

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Re: o-acetyl loperamide
« Reply #11 on: June 26, 2011, 02:35:39 PM »
Tryl, I would greatly advise against running a new reaction and following it up with looking for a vain to send it in. This WILL be the death of you if you do not use caution.

Test your products in small doses under safer conditions other then shooting it in your vain as soon as your finished.

Please be careful.
There once were some bees and you took all there stuff!
You pissed off the wasp now enough is enough!!!

The Lone Stranger

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Re: o-acetyl loperamide
« Reply #12 on: June 26, 2011, 02:42:11 PM »
Very true . The problems are noit only posible alergic reactions , impuritys and possible bad / failed chemistry its also about doseing things ........ one needs a hell of a good set of scales once the potency starts going up .

tryl

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Re: o-acetyl loperamide
« Reply #13 on: June 26, 2011, 02:52:47 PM »
yes.

i am well aware of all this.

but, as the latin saying goes, Video meliora, proboque, deteriora sequor.

as for dosage, i knew this wasn't anything to be concerned with in this particular scenario.
"In the words of Archimedes, give me a lever long enough and a place to rest it... or I shall kill one hostage every hour."

Sedit

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Re: o-acetyl loperamide
« Reply #14 on: June 26, 2011, 05:19:53 PM »
yes.

i am well aware of all this.

but, as the latin saying goes, Video meliora, proboque, deteriora sequor.

as for dosage, i knew this wasn't anything to be concerned with in this particular scenario.

Your messing around with a possible Fentanyl analog and your telling me that 17mg as a test dose is nothing to be concerned about? You are very clueless about what your getting yourself into and you really need to do more research before you proceed. There has already been one death that I know of from Loperamide analogs and I fear you will soon be the second if you don't pull your head out of your ass.

As the saying goes there are old chemist and bold chemist but there are no old bold chemist. This is 10 times as true when it comes to this sort of chemistry.
There once were some bees and you took all there stuff!
You pissed off the wasp now enough is enough!!!

tryl

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Re: o-acetyl loperamide
« Reply #15 on: June 29, 2011, 01:20:48 PM »
yes.

i am well aware of all this.

but, as the latin saying goes, Video meliora, proboque, deteriora sequor.

as for dosage, i knew this wasn't anything to be concerned with in this particular scenario.

Your messing around with a possible Fentanyl analog and your telling me that 17mg as a test dose is nothing to be concerned about? You are very clueless about what your getting yourself into and you really need to do more research before you proceed. There has already been one death that I know of from Loperamide analogs and I fear you will soon be the second if you don't pull your head out of your ass.

As the saying goes there are old chemist and bold chemist but there are no old bold chemist. This is 10 times as true when it comes to this sort of chemistry.

i know people have been slamming 100+mg of the propyl ester + i didn't bang the whole 17mg at once.
"In the words of Archimedes, give me a lever long enough and a place to rest it... or I shall kill one hostage every hour."

Tsathoggua

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Re: o-acetyl loperamide
« Reply #16 on: June 29, 2011, 05:11:44 PM »
There was me thinking that saying was limited to mycologists.

Thats what we say, there are old mushroom hunters, and bold mushroom hunters, but no old, bold mushroom hunters.
Pick something nasty, and if you are lucky, you will just get very sick, but if you are unlucky, then you shit your liver and kidneys out in smoothie form.

As for loperamide, I have grave doubts as to its safety. There have been studies where it was injected into piglets, with an incomplete BBB due to their age and they developed parkinsons disease, due to a similar thing going on to MPPPs action. One can lose 70+% of the dopaminergic neurons in the substantia nigra and not know it, but after that, its incredibly severe, chemically induced parkinson's disease.

Not sure of the safety of esters, but bear in mind the body packs a fairly comprehensive collection of esterases, as if esters weren't touchy enough as they are, that will rip them to shreds. Part of the danger of MPTP comes from its being charged, and once in cells, and converted from MPPP to MPTP by MAO-b (administration of a MAO-b inhibitor prevents this from happening and removes the neurotoxicity inherent there) it fries them extra crispy, and it cannot leave due to the charge. It would prevent it from ever getting there in the first place, if MPTP were taken, due to inability to pass the BBB, but once there, it can't come out, and sits there, frying away.

Do you want to find out that it is neurotoxic, or it converts in part to loperamide once in the CNS? I wouldn't want to have to pick substantia nigra tissue bogies out of my nose, having to wipe brain tissue under the tables in macdonalds is not an edifying thought.

Sedit-I was unaware of a death due to loperamide analogs, can you elaborate?
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Sedit

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Re: o-acetyl loperamide
« Reply #17 on: June 29, 2011, 05:20:54 PM »
Quote
Sedit-I was unaware of a death due to loperamide analogs, can you elaborate?

A while back some girl showed up over at Wetdreams claiming Jon was dead. She was convinced that Jon was her brother because he had managed to overdose on Loperamide coated with the special nano particles everyone use to speak of. I spoke with her for a bit Via PM and helped her find what where basically her brothers last words describing how he prepared the Loperamide. After that she vanished and that's all the information I have. I don't believe it was a trick at all and she said he had been using this for months now and since he figured out how to make it active he stopped other opiates because it was just to easy to get the Loperamide.

This shit is no joke, its a cat I wish would get put back in the bag and kept in a close nit circle of people that would be able to handle having unlimited supply of an opiate. BTW I want someone to inject a large dose of Loperamide and tell me honestly that they feel nothing. There is minor activity in this and I think alot of the reports are a cross between placebo and mild activity.


:Edit::: Sorry it wasn't Jon she said was dead it was Beebo, I just remembered.
« Last Edit: June 29, 2011, 05:22:28 PM by Sedit »
There once were some bees and you took all there stuff!
You pissed off the wasp now enough is enough!!!

Sydenhams chorea

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Re: o-acetyl loperamide
« Reply #18 on: October 15, 2011, 07:18:49 PM »
Is no-one afraid of possible contamination with the elimination product, as it is a structural analogue of MTPT?

It is perhaps the narcotic. Hyoscine affects certain people very oddly. One cannot be sure. Sometimes, these cases take strange forms. The victim becomes in a sense, 'mediumistic', a vehicle for all the intangible forces in operation around her.

jon

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Re: o-acetyl loperamide
« Reply #19 on: October 16, 2011, 01:20:26 AM »
the choro atom on the benzne ring really holds it back.
it's like fentanyl in that it's great at first and tolererance goes up lightning fast and it's no fun anymore.
tacyphylaxis it's callled.
it's no more than 3-4 X morphine without the chlorine atome it's unfetttered to bind to the mu opiate receptors the chlorine really stearically blocks it cuts it potency down by 30.
Be careful - I don't know whether jon has a bioassy (of a pure product?) but, to anyone reading this, check the papers I've uploaded in this thread. - Enkidu
you can use ammonium formate and pd/c to knock it off in methanol.
when things are'nt  so hectic i'll get references and we can start in earnest on the hydrodechlorination.
this is the best way yeilds are 100% done i 30 minutes room temp etc, etc.
and it's chemoselective the ydride donor is selective and won't reduce the tert-alcohol i smacked my forehead when i learned all of this.
« Last Edit: October 19, 2011, 03:56:00 AM by Enkidu »