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Author Topic: MST extraction & sulfate to base/HCl conversion  (Read 158 times)

tryl

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MST extraction & sulfate to base/HCl conversion
« on: August 10, 2011, 08:06:33 PM »
so i've been trying to squeeze the morphine sulfate out of the rest of the junk & waxes.

i tried dissolving the crushed pills in acidic water (dissolving citric acid prior to), heating, adding non-polar carbohydrate solvent (used a paint stripper i had nearby, which was made up from mineral turpentine and orthoxylene). i thought about using toluene instead, perhaps mixed in with petroleum ether, but those were unavailable at the moment.

the organic layer seemed to not pull much, if anything.
i don't mind experimenting til i get it, but i don't have as much resource.

then, the conversion part:
1) would adding HCl (is HCl strong an acid enough) straight to the m.sulfate solution break the sulfate and convert to HCl?
2) adding ammonia or 10% NaOH to pH 8.5/9 and then freeze/cool precipitating perhaps? to get tha base.
3) or just shove sodium carbonate?
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reDEEMed

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Re: MST extraction & sulfate to base/HCl conversion
« Reply #1 on: August 10, 2011, 10:22:24 PM »
This is relevant to my interests. I'm currently on 120mg of morphine sulfate per day and that will no doubt go up every month. I can't go experimenting with all my medication, but I would try with a few here and there. Maybe when can split our efforts until we find a good way of washing these pills. Sounds like you have already tried the things I have had bouncing around in my head for a while now, so scratch that, I'm glad you did it and not me lol. But, that's the advantage of more than one of us trying shit.

As for the salt, do you know that HCl is the best for morphine? I'd be willing to try some others. I have a whole assortment of acids to try. Why do the manufacturers go with the sulfate, do you know?
"Ego is a structure that is erected by a neurotic individual who is a member of a neurotic culture against the facts of the matter. And culture, which we put on like an overcoat, is the collectivized consensus about what sort of neurotic behaviors are acceptable."
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hypnos

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Re: MST extraction & sulfate to base/HCl conversion
« Reply #2 on: August 11, 2011, 03:14:27 AM »
  Its has been noticed there are 2 rather efficient methods for extracting the morphine from these tablets

1) Cold water extraction--remove colored extenal coating with IPA swab or such, let dry a few mins and then put in the crease of a piece of paper and fold the edges, and crush to the smoothest powder you can get
  Carefully pour this into an 'appropriate container' to mix thoroughly into as milky a solution as possible,,,,leave for ten minutes and pour into big spoon, drop a large-half a cotton ball- piece into the spoon and then, using a syringe WithOut a needle,, push this gently into the centre of the cotton wool and start drawing it up.
 Morphine IS very water soluable, so rather than remove the gunk, remove the morphine

  AT LEAST 2mls of water per 100mg of MSC are needed to get a reasonabe extraction

 If you can get Pill Filters, Use them!!! they work a treat...as with most procedures of this nature, it has some inconsistencies

 BUT..the NEWS IS,,,clean em, crush em and parachute them....stick it up your arse....BYPASSES metabolic Oral problems.. My cat did this with 120mg yesterday,, and slept happily ALL day

  Theres more, so I hear, but time waits for no man or microbe

 Laters friends

  Hyppy
"the two things you can give away and never lose, are what you know, and how you feel...."

reDEEMed

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Re: MST extraction & sulfate to base/HCl conversion
« Reply #3 on: August 11, 2011, 07:04:33 AM »
I've done cwe several times on hundreds of vicodin at a time, and for that, it works well. But, for 10-20 tiny pills that use wax in the binder you're talking more water than I wanna fuck with. There has to be a chemical solution to the problem.

Somebody knows, but they aint gonna say shit.
"Ego is a structure that is erected by a neurotic individual who is a member of a neurotic culture against the facts of the matter. And culture, which we put on like an overcoat, is the collectivized consensus about what sort of neurotic behaviors are acceptable."
— Terence McKenna

hypnos

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Re: MST extraction & sulfate to base/HCl conversion
« Reply #4 on: August 12, 2011, 05:56:26 AM »
 Morphine sulphate dissolves about 60mg/ml  in 'room temp water, this should only take about 10 mins  for the morphine to dissolve IF your powder IS Dry and Very Fine

 Cheers Hyppy

  If an intravenous method of extraction is desired,  there are more, but bootin it is safer, and better! however if your frustration becomes great, pm me  Stay happy
"the two things you can give away and never lose, are what you know, and how you feel...."

reDEEMed

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Re: MST extraction & sulfate to base/HCl conversion
« Reply #5 on: August 12, 2011, 01:16:50 PM »
I stay full of opiates, I'm not anxious or in a hurry at all. I get hydrocodone still on top of the morphine and I have a bottle full of methadone as well. I don't shoot up anymore, so the only purpose of extraction would be to augment the chemical structure of my medication somehow to obtain something stronger, not so I could shoot the morphine.

I'm just saying to the op that I will help by doing tandem experimentation so we can make the most out of the little bit of morphine we have between us. I would like to have a method for washing these pills just because. The wax binder makes cwe somewhat wasteful.
"Ego is a structure that is erected by a neurotic individual who is a member of a neurotic culture against the facts of the matter. And culture, which we put on like an overcoat, is the collectivized consensus about what sort of neurotic behaviors are acceptable."
— Terence McKenna

Sedit

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Re: MST extraction & sulfate to base/HCl conversion
« Reply #6 on: August 12, 2011, 05:16:27 PM »
Im not 100% sure what Tryl was attempting to do with the Non polar, where you trying to get the wax or the Morphine.

Why not just dissolve them in excess water and filter. Basification should precipitate the Morphine base.
There once were some bees and you took all there stuff!
You pissed off the wasp now enough is enough!!!

reDEEMed

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Re: MST extraction & sulfate to base/HCl conversion
« Reply #7 on: August 12, 2011, 07:47:26 PM »
You really don't see a problem with using water when what we want is mixed with wax?

I had thought about simulating the stomach with a little HCl lol. I don't want to waste any of my medicine, it is vital to me living a somewhat pain free life. Since I get the 60mg pills I don't have that much wax to contend with, but I just want to take every precaution that I'm not throwing away my medication.
"Ego is a structure that is erected by a neurotic individual who is a member of a neurotic culture against the facts of the matter. And culture, which we put on like an overcoat, is the collectivized consensus about what sort of neurotic behaviors are acceptable."
— Terence McKenna

Sedit

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Re: MST extraction & sulfate to base/HCl conversion
« Reply #8 on: August 12, 2011, 09:21:06 PM »
Nope, I really don't see the problem.

Morphine sulfate is not soluble in wax so worse case scenario it repeals water at first. If this is the case then heat it and melt the wax. When melted the wax will act like a non polar solvent and the salt will fall into the water solution. On cooling the wax will congeal where it can be removed.

Given the solubility of Morphine salts in water you can bet that little loss will be had other then mechanical error.
There once were some bees and you took all there stuff!
You pissed off the wasp now enough is enough!!!

reDEEMed

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Re: MST extraction & sulfate to base/HCl conversion
« Reply #9 on: August 13, 2011, 01:44:53 AM »
Hmmm, thanks then, I think :D
"Ego is a structure that is erected by a neurotic individual who is a member of a neurotic culture against the facts of the matter. And culture, which we put on like an overcoat, is the collectivized consensus about what sort of neurotic behaviors are acceptable."
— Terence McKenna

hypnos

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Re: MST extraction & sulfate to base/HCl conversion
« Reply #10 on: August 13, 2011, 02:55:10 AM »
  Sedit is correct....that said,, IF Pain management is paramount, BUT,, you still use an Oral ROA you WILL lose up to 50+% of the morphine due to metabolic processes---reverse the ROA and maximize the amount available to BE bioavialable, here is just one of many reports to be found online
Quote
crossover clinical trial of oral versus rectal morphine administration in opioid- naive cancer patients with pain

F De Conno, C Ripamonti, L Saita, T MacEachern, J Hanson and E Bruera
Pain Therapy and Palliative Care Division, National Cancer Institute, Milan, Italy.

PURPOSE: The aim of this double-blind, double-dummy, crossover study was to compare the efficacy, tolerability, and time of onset of analgesia after the administration of 10 mg of morphine hydrochloride via the oral and rectal routes in opioid-naive cancer patients with pain. PATIENTS AND METHODS: Thirty-four patients with cancer pain and no previous opioid treatment were randomized to receive morphine hydrochloride 10 mg orally or rectally (in the form of a microenema) for 2 days. During days 3 and 4, a crossover took place. The scores of pain, nausea, and sedation (visual analog scale of 0 to 100) calculated as the percentage change from baseline (before opioid administration) were assessed at different intervals up to 240 minutes. The number of vomiting episodes was recorded. Parity tests and analysis of variance (ANOVA) were performed to compare the two administration routes. RESULTS: A significant difference in pain intensity was achieved 10 minutes after rectal administration compared with 60 minutes after oral administration. There was still a significant reduction in pain via the rectal route after 180 minutes versus via the oral route after 120 minutes. No significant difference was observed in the intensity of sedation, nausea, or number of vomiting episodes between the oral and rectal routes. CONCLUSION: A liquid solution of morphine is well absorbed via the rectal route. Rectal morphine is safe, effective, easy to manage, and inexpensive, with a rapid onset of action. Rectal morphine can be considered a valid alternative route for opioid administration and may also be used when rescue doses of morphine are required in patients regularly treated with oral or parenteral opioids.

BTW "
"The absorption rate and bioavailability could be greatly improved, as compared to orally administered morphine, by adjusting the pH. It was concluded that a rectal solution adjusted to pH 7 to 8 provided an entirely adequate dosage form."

  So, add a pinch of baking powder, or similar to basify  solution, to improve absorption ;)

AND; using the morph in at Least,, 60mg per 1ml (preferably 3mls per 100mg)  SOLUTION;   using a syringe (Without! a needle) to introduce the solution, about 2" into your anal cavity, will do the trick...also you will probably feel like having a crap shortly thereafter...DONT...wait AT LEAST 30 mins--go first, if anything ;)

 Have a look, ROA's have become a recent interest of the beer I see down the local, that suggests such things :o

  peace love and painfree 8)

  Hyppy
« Last Edit: August 13, 2011, 03:51:19 AM by hypnos »
"the two things you can give away and never lose, are what you know, and how you feel...."
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