Author Topic: L-PAC or 1-phenyl-1,2-propane dione? (Read 76 times)

XuTai10 · « **on:** September 08, 2011, 09:00:00 PM »

Hi, please help on the choice of substances intended for the hydrogenation of d-ephedrine hydrochloride. I have to choose between these two ingredients: l-phenylacetylcarbinol or 1-phenyl-1 ,2-propane dione.

l-phenylacetylcarbinol seems to me that it was standard procedure for the simple hydrogenation of methylamine in the environment 2.5 on palladium catalyst for a better and more efficient choice.

What is your opinion on this?

(sorry for my English is not very good)

Sedit · « **Reply #1 on:** September 08, 2011, 10:25:09 PM »

1-phenyl-1 ,2-propane dione will aminate at both carbonyls making a royal mess and yielding nothing in the way of desired product.

I am moving this to short questions where I wish you to keep all short... questions.

XuTai10 · « **Reply #2 on:** September 09, 2011, 10:41:20 AM »

Could anyone advise how to hydrogenate 1-phenyl-1 ,2-propane dione, if not the same as L-phenylacetylcarbinol?
The desired hydrogenation product is d-ephedrine hydrochloride or d-pseudoephedrine hydrochloride.

Thank you in advance for any response.

lugh · « **Reply #3 on:** September 09, 2011, 12:09:07 PM »

Quote

Could anyone advise how to hydrogenate 1-phenyl-1 ,2-propane dione, if not the same as L-phenylacetylcarbinol?
The desired hydrogenation product is d-ephedrine hydrochloride or d-pseudoephedrine hydrochloride.

An article using Baker's Yeast enzymes to do the transformation is attached

It's on Rhodium's page

Author Topic: L-PAC or 1-phenyl-1,2-propane dione? (Read 76 times)

XuTai10

L-PAC or 1-phenyl-1,2-propane dione?

Sedit

Re: L-PAC or 1-phenyl-1,2-propane dione?

XuTai10

Re: L-PAC or 1-phenyl-1,2-propane dione?

lugh

Re: L-PAC or 1-phenyl-1,2-propane dione?