Author Topic: Lab-Free GBL to GHB  (Read 214 times)

fatfreddy

  • Larvae
  • *
  • Posts: 29
Lab-Free GBL to GHB
« on: September 28, 2011, 02:17:00 AM »
I apologize if this topic is too pedestrian for this subforum, it just didn't seem to fit anywhere else. Feel free to move it.

So, many of you probably know the necessary background information with GHB, but I'll write a brief summary. GHB is now a Schedule I drug in the US, and is more or less impossible to find. However, it is very easy to produce from GBL, its cyclic derivative. A basified solution is used to reduce it to GHB, which is then salted out. Furthermore, GBL converts to GHB in the body, so some consume it directly. GBL is a List I precursor, but is very easy to source in research chemical circles because people use it directly.

This brings me to my question. Could one prepare GBL for consumption in a way that could convert it to GHB before it ever enters his body? For example, could he make a warm or hot aqueous solution with baking soda, and let the GBL sit in it for a while? If it readily converts in the body, couldn't you mimic those conditions externally? He could even neutralize the pH with orange juice, vitamin C, or citric acid if necessary.

A lot of the effort in GHB synthesis seems to be put into purification and salting. Obviously, that wouldn't be necessary if you could convert the amount of GBL that you wanted in a drinking glass, and then down it.

I only ask because some express concerns about the health profile of GBL in the body before it is converted. Its duration is significantly longer tham GHB's because it takes so long to convert.

I'll attach a few links to information about GHB synthesis (it's really damn simple) if that would give anyone a better idea of what might be possible.

http://www.erowid.org/chemicals/ghb/ghb_faq2.shtml
http://www.erowid.org/archive/rhodium/chemistry/ghb.html

fractal

  • Subordinate Wasp
  • ***
  • Posts: 110
Re: Lab-Free GBL to GHB
« Reply #1 on: September 28, 2011, 05:00:10 AM »
You just answered your own question with the link you posted.

fatfreddy

  • Larvae
  • *
  • Posts: 29
Re: Lab-Free GBL to GHB
« Reply #2 on: September 28, 2011, 11:21:15 AM »
You just answered your own question with the link you posted.
Where in the links, exactly? They both seem to involve lab synthesis.

atara

  • Dominant Queen
  • ****
  • Posts: 256
Re: Lab-Free GBL to GHB
« Reply #3 on: September 28, 2011, 05:26:04 PM »
To 1.25 mL of gamma-butyrolactone there was added one human liver. Subject became intoxicated rather quickly...

fatfreddy

  • Larvae
  • *
  • Posts: 29
Re: Lab-Free GBL to GHB
« Reply #4 on: September 28, 2011, 09:59:34 PM »
So, no one? :p

fatfreddy

  • Larvae
  • *
  • Posts: 29
Re: Lab-Free GBL to GHB
« Reply #5 on: September 28, 2011, 11:27:21 PM »
Quote
Preparation of Sodium GHB using Sodium Bicarbonate (Baking Soda, NaHCO3)
Written by Chromic

Add 273 g NaHCO3 (3.25 moles) to 1125 mL distilled water in a glass container. Slowly bring the solution to a boil while stirring with a glass rod or similar. All of the baking soda will dissolve. Carbon dioxide will be seen leaving the solution as it comes to a boil. This is the sodium bicarbonate breaking down into a slightly strong base, sodium carbonate:

2 NaHCO3 -> Na2CO3 + H2O + CO2

Reduce the heat to a light boil, and slowly add 250ml gamma-Butyrolactone (280g, 3.25 moles). The addition is not immediately exothermic as with the sodium hydroxide synthesis. Keep this solution at a light boil for 30 minutes. Check the pH with universal pH paper. We are aiming for a pH around 7, but anything 6 to 8 is perfectly safe. If the pH is too high, add a small amount more GBL and continue to reflux.

The solution will be perfectly clear and should be absolutely colorless. If it is not perfectly colorless, i.e. if slightly impure butyrolactone was used and the solution has taken on a light yellow color, add about 100 mL of activated charcoal. Allow this to boil for 10 minutes. Cool the solution then filter, washing the activated charcoal two or three times with 50 ml portions of cold water. 410g of NaGHB will be made in this synthesis. This solution can be concentrated to about 50% NaGHB before it will start to crystallize. If you wish for a powder, heat until the temperature of the solution reaches 150°C then pour onto a flexible metal sheet and allow it to cool and solidify.

This synthesis is perfect for use where there is no ACS, Food or Electronics grade sodium hydroxide available.

This could maybe work with boiling water in a tea cup...

marakov

  • Pupae
  • **
  • Posts: 74
Re: Lab-Free GBL to GHB
« Reply #6 on: September 30, 2011, 07:10:20 AM »
To 1.25 mL of gamma-butyrolactone there was added one human liver. Subject became intoxicated rather quickly...

Alternative method:

1 pig liver (source: butcher's store) enzyme extract from blender combined with gbl in chilled vessel with stirring (30m - 3hrs) followed by extraction of ghb. Some mechanical loss is to be expected but the conversion ratio is nearly perfect... so its a some thing. Only a small amount of enzyme would be needed to do a large batch conversion of gbl. Expect many side products. Reaction requires inhibitors.

I think I have put too much thought onto this.


Tsathoggua

  • Autistic sociopath
  • Foundress Queen
  • *****
  • Posts: 662
Re: Lab-Free GBL to GHB
« Reply #7 on: September 30, 2011, 06:13:42 PM »
Christ...you can make GHB from GBL in a fucking coffee pot with NaOH, H2O and some alcohol, if you want to speed up evaporation. Are you really going to bee prepared to waste money buggering about with pig liver.

And sure as hell I am not going to drink a slurry of pig liver, GBL, GHB and god only knows what else. Chances are your GBL would get oxidised all the way to CO2, succinic acid, GABA, and a load of other useless stuff. Not a viable route, unless the isolated enzymes were used, seperated from liver using electrophoresis etc. Damn complex, damn expensive.

Just dose the GBL as is, even. Personally I avoid it entirely due to potential for excitotoxicity. Thats permanent damage we are talking about. Reaction with NaOH is a piece of piss.
Nomen mihi Legio est, quia multi sumus

I'm hyperbolic, hypergolic, viral, chiral. So motherfucking twisted my laevo is on the right side.

RoidRage

  • Dominant Queen
  • ****
  • Posts: 386
Re: Lab-Free GBL to GHB
« Reply #8 on: September 30, 2011, 06:59:51 PM »
I'm pretty sure he was joking ;D

Tsathoggua

  • Autistic sociopath
  • Foundress Queen
  • *****
  • Posts: 662
Re: Lab-Free GBL to GHB
« Reply #9 on: September 30, 2011, 07:47:22 PM »
Refer to my user title:D

If in doubt, refer to it again. It wouldn't even work in theory. Human liver does the job, and it metabolised GBL all the way to succinic acid, GABA and eventually CO2. So one would never be able to obtain GHB from a full liver enzyme fraction. Couldn't make it stop at GHB, one would get the entire metabolic pathway, at least without some incredibly painstaking and expensive experimentation.
Nomen mihi Legio est, quia multi sumus

I'm hyperbolic, hypergolic, viral, chiral. So motherfucking twisted my laevo is on the right side.

RoidRage

  • Dominant Queen
  • ****
  • Posts: 386
Re: Lab-Free GBL to GHB
« Reply #10 on: September 30, 2011, 08:07:29 PM »
Haha thanks for elaborating ;D