Pages: 1

Author Topic: PCP from Piperidine  (Read 234 times)

hyjroul

  • Larvae
  • *
  • Posts: 41
PCP from Piperidine
« on: October 22, 2011, 12:34:14 PM »
Well, hello again, as you can see in the UN paper of drug routes, they say that piperidine + hcl gives PCP (phenylciclohexylpiperidine) this is obviously incorrect, but i have a doubt, how the PCP chemists in 70's 80's 90's made his PCP? Well in my country there weren't any case of pcp in blood analysis or pcp overdose etc.. it's a myth drug every one heard of this but any person tried it, never in the history i'm saying (except when the medicine was legal) so never a pcp chemist. We all know the classic p-toluenesulfonic cyclohexanone piperidine, but my question is , you americans how your chemists made the dust? in my country everyone heard that is made homemade like methamphetamine, with otc things.

Correct me if im mistaked.

Thank you in addvance and sorry for my bad english and explanation i hope you understood it!

java

  • Global Moderator
  • Foundress Queen
  • *****
  • Posts: 783
Re: PCP from Piperidine
« Reply #1 on: October 22, 2011, 02:19:48 PM »
Search the net......read this....java

Clandestine Drug Synthesis
William H. Soine
Med. Res. Rev. 6(1), 41—74 (1986)

http://www.erowid.org/archive/rhodium/chemistry/clandestine.drug.synthesis.html
« Last Edit: October 22, 2011, 02:23:29 PM by java »
¡Prefiero morir de pie que vivir siempre arrodillado!.Emiliano ZapataIt is better to die on your feet than to live on your knees!.......

dream0n

  • Subordinate Wasp
  • ***
  • Posts: 204
Re: PCP from Piperidine
« Reply #2 on: October 22, 2011, 04:34:38 PM »
From That link: The information regarding PCP synthesis

Quote
1-(1-Phenylcyclohexyl)piperidine (phencyclidine, PCP), is the prototypic compound of the class referred to as arylcycloalkylamines.179
 Two basic methods of clandestine manufacture of PCP have been observed. The most common method (84% of the clandestine laboratories in the United States), uses 1-piperidinocyclohexanecarbonitrile (PCC) as a synthetic intermediate (Fig 12).3
 This intermediate is prepared from the bisulfite addition product of cyclohexanone followed by treatment with potassium cyanide and piperidine180 or by directly mixing piperidine hydrochloride, cyclohexanone and potassium cyanide181 to yield beautiful white, ice-like crystals of PCC.
PCC is then dissolved in either diethylether or kerosene and reacted with phenylmagnesium bromide to give PCP. The literature yields for the last step range from 55 to 73%.
The alternative method for preparing PCP is through formation of the enamine, 1-(1-cyclohexenyl)piperidine, conversion to the imine with p-toluenesulfonic acid and reaction with phenylmagnesium bromide.182
Approximately 16% of the laboratories were using this method.3 An alternative synthetic intermediate, 1-phenylcyclohexylamine,181 is listed in the Controlled Substances Act as a Schedule II immediate precursor to PCP, however, it has not been observed to be clandestinely manufactured.
off to bigger and better things - don't worry I will visit from time to time

hyjroul

  • Larvae
  • *
  • Posts: 41
Re: PCP from Piperidine
« Reply #3 on: October 23, 2011, 12:48:28 AM »
Of course i did know you seem to misunderstood this but anyways i know the routes for pcp buti'm thinking if it was any ''secret recipe'' in your country you know? like OTC everyone in my country thinks phencyclidine in usa is made in your kitchen without any other shit, and in ALL cities they believe i mean.

java you are mexican or southamerican yes? i know the spanish languaje! Que pasa tio!

Un abrazo fuerte, this forum is THE FORUM!  ;D

POSEIDON

  • Subordinate Wasp
  • ***
  • Posts: 116
Re: PCP from Piperidine
« Reply #4 on: October 24, 2011, 01:42:06 AM »
Look  this pdf
The chemists are a strange class of mortals, impelled by an almost insane impulse to seek their pleasures amid smoke and vapour, soot and flame, poisons and poverty; yet among all these evils I seem to live so sweetly that may I die if I were to change places with the Persian king.
— Johann Joachim

nk40ouvm

  • Pupae
  • **
  • Posts: 73
Re: PCP from Piperidine
« Reply #5 on: October 24, 2011, 11:07:16 PM »
Quote from: POSEIDON on October 24, 2011, 01:42:06 AM
Look  this pdf

Nice document. The "bucket method" is something you could expect to see in a kitchen lab, but getting the precursors requires either ordering watched chemicals or doing a fair bit of preliminary chemistry to make them.

For the chemist determined to avoid watched materials: The cyanide can be made starting from urea and baking soda. The metabisulfite is OTC at brewing suppliers. Cyclohexanone can be separated from PVC pipe joiner compound by distillation. Piperidine is available from basic hydrolysis of piperine from pepper (doing it in ethylene glycol with KOH should allow product to distill out easily; boils 90 degrees below the solvent). Making bromobenzene starting from sodium benzoate and sodium bromide (benzoate -> benzene, bromide -> bromine, benzene + bromine + iron -> bromobenzene) is straightforward if tedious.

The worst part of this hypothetical OTC path is getting the piperidine; you need to process a hell of a lot of black pepper to get 200 g of piperidine. It's very doubtful that anyone who ever actually used the "bucket method" relied on purely OTC chemicals. It's not inconceivable that a cautious chemist who just wants a small amount of product could produce his piperidine this way, though.

There is one very amusing statement of 1993 vintage in the document: "[explanation of possible synthesis improvement] ... However, it is doubtful that clandestine chemists can utilize a composite literature approach to a synthetic problem." Little did they know that the World Wide Web was going to make literature research one of the smart clandestine chemist's easiest and most common chores!

uchiacon

  • Larvae
  • *
  • Posts: 46
Re: PCP from Piperidine
« Reply #6 on: October 25, 2011, 07:11:27 AM »
Couldn't you source piperine from china quite easily? I don't know the pricing, but there appears to be plenty of suppliers. If you're willing to take a gamble and order samples from one or two companies I'm sure that you'll get lucky.

nk40ouvm

  • Pupae
  • **
  • Posts: 73
Re: PCP from Piperidine
« Reply #7 on: October 25, 2011, 08:31:38 PM »
Quote from: uchiacon on October 25, 2011, 07:11:27 AM
Couldn't you source piperine from china quite easily? I don't know the pricing, but there appears to be plenty of suppliers. If you're willing to take a gamble and order samples from one or two companies I'm sure that you'll get lucky.

Sure, it's possible and maybe even good advice in the short term. But advice like "just order [somewhat obscure but unmonitored chemical] from [place] to help make [product]" either can't be replicated widely or can't be expected to last. I'm more interested in chemistry than product anyhow, so it makes sense for me to research how you can start from truly ubiquitous substances. Others who want to do more sourcing and less bench work can streamline my ideas by ordering intermediates instead of making them.

hyjroul

  • Larvae
  • *
  • Posts: 41
Re: PCP from Piperidine
« Reply #8 on: October 26, 2011, 02:16:20 PM »
The problem here it's with the risk of cyanide gas liberation...
Pages: 1