This is my first post in the hive with the exception of my member introduction. I'd just like to say that i am very excited to start discussing topics as i have finally found the courage to post threads after a long time of being a forum scavenger. If you'd like to know more about me, check out my introduction.

I've been reading on the topic of loperamide for quite some time now. I am trying to wrap my mind around things and hopefully soon perform an experiment on some imodium i recently picked up from the pharmacy. I hope that at least some of my questions can be answered.

1. As I am still in highschool, living at home with my parents, what would be the most efficient way to potentiate loperamide? (i.e esterifying it, using a uv light and ipa, removing the -Cl, etc.)
2. Since i'm going to assume that esterfication would be the best process, what are the most useful chemicals to produce the ester form?
2b.. I have heard from a friend that there is a route in which anhydrous ipa and distilled water are used... have you heard of this and are able to elaborate on it? I have also heard of a process involving GAA but it sounded a bit more complicated.
3. Do i have to isolate the loperamide from the filler to experiment with it, or can the imodium pills be used as is?

Thank you so much!

I've read many threads by jon with a lot of references to show that this process is quite promising, however caution and safety is always put first in response to your warnings. I am mostly looking for some clarification to help narrow my research

Depends what's in the pills. Never had that stuff around so no good answer for that, sorry. You might be able to wash it a few times with a nonpolar solvent then do an acid/base extraction but again it really depends on what's in it.

thanks jon i was informed the same thing by poison

like i said read the deschloro thread no need to double post.

did'nt make me feel that way.
it has some mild euphoria not as pronounced as heroin but it was alright.
i don't know about that dehydration you're talking about.

when i first tried it i thought it was great  some of the best euphoria i felt was from mixing dipropionyl morphine with propionyl loperamide.

I don't think anything tops heroin.

Sedit, didn't you once say elsewhere that you found codeine to be the most enjoyable of all opiates? Perhaps it could be that your body chemistry is different? People seem to disagree a lot on what opiates they think are the most enjoyable, for example there are many who say fentanyl has zero euphoria, and yet there are some who say it produces "god-like" euphoria.

Doubtful, I might have said I don't feel its as weak as most people think.

Glacial acetic acid with a small amount of H₂SO₄ / NaOAc was used. It was warmed for 24 hours with anhydrous MgSO4. It was evaporated to dryness and Anhydrous MeOH was added and was filtered. This solution was evaporated to yeild a small amount of light green powder. Roughly 10mg produced a noticeable change but it was just a dopey feeling with almost no Euphoria. The next day I felt very hung over with a massive headache and it felt as though I had spend the night drinking whiskey or something.

It was a very crude experiment but it did show me it was crossing the into the brain however it just was not very enjoyable. Most experiments should be performed I just don't feel the potential is there like others think it is.


PS: Also yes, my body chemistry is very unusual however its mostly the GABA system that is fouled up and possibly some difference in stomach enzymes. For the most part Opiates respond rather typical for me.

Whatever may have occurred without a doubt allowed it to cross into the CNS yet the effects where less then spectacular.