Author Topic: Novel opiate ah-7921 (Read 353 times)

myCH3 · « **on:** February 26, 2012, 09:36:20 PM »

came across this novel opiate thought you guys would find it cool as well. give mad props
to borohydride over at opiaphiles for tuning me onto this.
called ah-7921 heres the wiki: hxxps://en.wikipedia.org/wiki/AH-7921. US Patent
3975443 has a 1-step, RT synthesis yielding over 70%.
it can be found here: hxxp://www.google.com/patents?id=N7YuAAAAEBAJ&pg=PA3&zoom=4
"US Patent 4346101 has a lower yielding & more fiddly route (Lednicer makes EVERYTHING complex)
BUT he uses triethanolamine & THF in place of pyridine as the solvent system. His product has a
MP of 208-209 whereas the former patent is 215-216C so theirs seems purer. Recrystalization using
ethyl acetate/DCM seems simple enough..." Theres an improvised synthesis over on zoklet here
hxxp://www.zoklet.net/bbs/showthread.php?t=184092

DynoMiTe · « **Reply #1 on:** March 02, 2012, 03:03:33 AM »

I know this isn't about the synthesis of it but I actually have some on the way to me from a lab in china. I will post some papers about it. I am very excited for this arrival.

Here is a link that doesn't say much other than it is addicting. (http://books.google.com/books?id=AsJ...0index&f=false)

This paper says 5-HT prolonged the effect from AH-7921. (http://books.google.com/books?id=miI...ed=0CE8Q6AEwBg)

This is a PDF that Determines the receptors that mediate opiate side effects in the mouse, including AH-7921. (http://www.ncbi.nlm.nih.gov/pmc/arti...00701-0094.pdf)

This is a really good paper talking about it's addictive qualities, effective doses in Mice, Dogs, and Monkeys, also its analgesic properties. (http://www.ncbi.nlm.nih.gov/pmc/arti...00539-0171.pdf)

This is pubchem's page on it, not much info but it is the basics such as the molecule. (http://pubchem.ncbi.nlm.nih.gov/summ...760&loc=ec_rcs)

This article states that AH-7921 is equipotent as morphine. You have to be a member of the site to read the full article. (http://www.annualreviews.org/doi/abs...ode=pharmtox.1)

This is another paper saying it is equipotent. (http://books.google.com/books?hl=en&...h-7921&f=false)

myCH3 · « **Reply #2 on:** March 02, 2012, 03:52:22 AM »

hey man I recognize you, welcome to the vespiary thanks for the papers

fresh1 · « **Reply #3 on:** March 02, 2012, 06:05:33 AM »

hmmmm....too good to be true, imo

here's an pretty good resource for opiate compounds

The Ultimate Opioid Chemistry and Pharmacology Collection - Opioids Opiates Narcotic Analgesics Mu ? Delta ? Kappa ? Nociceptin ORL1 Opioid Receptor Ligands Full Mixed Partial Opioid Agonists Antagonists

http://www.scribd.com/collections/2688021/The-Ultimate-Opioid-Chemistry-and-Pharmacology-Collection-Opioids-Opiates-Narcotic-Analgesics-Mu-%CE%BC-Delta-%CE%B4-Kappa-%CE%BA-Nociceptin-ORL1-Opioid-Receptor-L?page=2

enjoy jonmon assyl and co, if you havent already

Balkan Bonehead · « **Reply #4 on:** March 02, 2012, 10:16:06 AM »

None of those links work, dynomite.

Balkan Bonehead · « **Reply #5 on:** March 02, 2012, 10:39:43 AM »

I wonder if it would work to synthesize 3,4 dichlorobenzoic acid from PABA by diazotization, nitration, reduction, and a second diazotization...

Assyl Fartrate · « **Reply #6 on:** March 03, 2012, 01:28:56 PM »

Quote

I know this isn't about the synthesis of it but I actually have some on the way to me from a lab in china. I will post some papers about it. I am very excited for this arrival.

Do share a bioassay of this compound!

Thanks for the papers everyone, good stuff.

fresh1 · « **Reply #7 on:** March 03, 2012, 01:37:26 PM »

hey ER . . . er...would 'what' work to synthesize 3,4 dichlorobenzoic acid?

and what would you do with/how would you go about using this carboxylic acid?

Something interesting to this forum or ?

Balkan Bonehead · « **Reply #8 on:** March 03, 2012, 08:53:29 PM »

There are some experience reports here: http://anonym.to/?http://www.bluelight.ru/vb/threads/602776-AH7921-Dosage

Balkan Bonehead · « **Reply #9 on:** March 03, 2012, 08:56:06 PM »

Quote from: fresh1 on March 03, 2012, 01:37:26 PM

hey ER . . . er...would 'what' work to synthesize 3,4 dichlorobenzoic acid?

and what would you do with/how would you go about using this carboxylic acid?

Something interesting to this forum or ?

Yes, that compound is used to synthesize the opioid under discussion. What I was wondering would work, is the procedure to make it that I summarized above.

fresh1 · « **Reply #10 on:** March 04, 2012, 04:17:46 AM »

sorry ER its just none of the OP's links seem to work, and I cant find much anywhere else...I cant even find the molecule

do you have some data you could post maybe

I think some of this Aaaaaah stuff to help me sleep!

PS. man! what IS IT with the links on this page? None seem to work including yours, although I can find bluelight ok

!!!

dream0n · « **Reply #11 on:** March 04, 2012, 05:24:16 AM »

My contribution, For starters
http://upload.wikimedia.org/wikipedia/commons/7/74/AH-7921_structure.png
Garbled Patent http://pastebin.com/dmNv6Wfr
http://en.wikipedia.org/wiki/AH-7921

"Direct combination of the 2 compounds below in anhydrous conditions:
3,4-Dichlorobenzoyl Chloride [CAS 3024-72-4]
(1-Aminomethyl-cyclohexyl) dimethylamine [CAS 41806-09-1]"
-Source- "http://anonym.to/http://forum.opiophile.org/showthread.php?31897-AH-7921-(Simple-to-make-home-)"

Google Patent 3975443 see attached

fresh1 · « **Reply #12 on:** March 04, 2012, 06:06:10 AM »

thanx dreamon now it all makes sense!

Dope Amine · « **Reply #13 on:** March 19, 2012, 04:55:00 AM »

I bought a couple grams of AH-7921 from a reliable supplier. Snorting 100 mg was very unpleasant and did not provide me with any exciting effects. I do have a tolerance (need 40-60 mg methadone to be ok) but I'm sorry, I have to say this one sucks.

Tsathoggua · « **Reply #14 on:** March 19, 2012, 05:38:06 AM »

I heard the aq. solubility was pretty low for this one, and hot water needed to be used to shoot the stuff. Read that it produces little rush, but still produces a decent opioid high.

Sounds kinda like oxy in that respect, as it seems to produce no rush at all when injected, although of course the H2O solubility of oxycodone is pretty good. Time to go shoot some up, come to think of it:D

fresh1 · « **Reply #15 on:** March 19, 2012, 08:25:24 AM »

thanx DopeAmine I guess if you think you got the goods, then it kinda puts this topic to rest!

could you do a MP test on what you got? that would be interedting

Dope Amine · « **Reply #16 on:** March 20, 2012, 03:47:53 PM »

A melting point apparatus is not something I have access to. Being that it's the HCl salt, I would imagine it to be fairly high so it would likely degrade anyway. I suppose if I made the freebase and then heated it slowly in an oil bath with a thermometer I could get a rough number but I honestly don't care to mess with this material anymore. If I'm in a desperate situation then maybe I'll eat like half a gram of this shit.

The most exiting thing I got from this vendor was actually one of the samples that came with the AH-7921: ethylphenidate. I can't believe how different it is from methylphenidate! It's like a cross between cocaine and meth. That's a solid material. Too bad I know uppers aren't a good thing for me...

myCH3 · « **Reply #17 on:** March 21, 2012, 04:00:25 AM »

Thanks for putting that to rest^ you've tried ethyphenidate as well I really liked the first go around and then ever subsiquent test were not that enjoyable.

fatfreddy · « **Reply #18 on:** March 21, 2012, 10:40:14 PM »

Quote from: Dope Amine on March 20, 2012, 03:47:53 PM

A melting point apparatus is not something I have access to. Being that it's the HCl salt, I would imagine it to be fairly high so it would likely degrade anyway. I suppose if I made the freebase and then heated it slowly in an oil bath with a thermometer I could get a rough number but I honestly don't care to mess with this material anymore. If I'm in a desperate situation then maybe I'll eat like half a gram of this shit.

The most exiting thing I got from this vendor was actually one of the samples that came with the AH-7921: ethylphenidate. I can't believe how different it is from methylphenidate! It's like a cross between cocaine and meth. That's a solid material. Too bad I know uppers aren't a good thing for me...

Not to get too off topic, but ethylphenidate does seem to be a very promising chemical. The only information available about it now is that it is produced when methylphenidate and alcohol are mixed (like cocaethylene) and that it shares methylphenidate's dopamine receptor affinity with less norepinephrine affinity. It'll definitely be interesting to see it progress in the RC world; it's largely an unavailable myth at the moment. I also feel that it's potential nootropic effects are currently ignored because most of the people sampling it are hardcore stimulant users that don't have much respect for subtleties or cognitive benefits.

Maybe we should get a separate ethylphenidate thread going, although I personally don't have much more to offer on the subject.

dream0n · « **Reply #19 on:** March 21, 2012, 11:43:28 PM »

There was one report that noted it as far greater aid for his 'ADD' than the methyl counterpart.
It can be made both from the base, ritalinic acid, and methylphenidate. There are both original patents on that, and more recent large-scale-tested synthesis documents found on erowid. Several labs, that specialize in research chemicals, have scaled-up successfully, both in europe and asia, are publicly known.
Use the search engine for those documents, i will post to a thread if one is made for this.
/ot

Author Topic: Novel opiate ah-7921 (Read 353 times)

myCH3

Novel opiate ah-7921

DynoMiTe

Re: Novel opiate ah-7921

myCH3

Re: Novel opiate ah-7921

fresh1

Re: Novel opiate ah-7921

Balkan Bonehead

Re: Novel opiate ah-7921

Balkan Bonehead

Re: Novel opiate ah-7921

Assyl Fartrate

Re: Novel opiate ah-7921

fresh1

Re: Novel opiate ah-7921

Balkan Bonehead

Re: Novel opiate ah-7921

Balkan Bonehead

Re: Novel opiate ah-7921

fresh1

Re: Novel opiate ah-7921

dream0n

Re: Novel opiate ah-7921

fresh1

Re: Novel opiate ah-7921

Dope Amine

Re: Novel opiate ah-7921

Tsathoggua

Re: Novel opiate ah-7921

fresh1

Re: Novel opiate ah-7921

Dope Amine

Re: Novel opiate ah-7921

myCH3

Re: Novel opiate ah-7921

fatfreddy

Re: Novel opiate ah-7921

dream0n

Re: Novel opiate ah-7921