The compound increases absorption and bio-availability of compounds lacking in it.
To understand how this is possible, we take a look at how it opens up transport channels.. by looking at its space filling 3d mol. model.
http://en.wikipedia.org/wiki/Cyclodextrin


" This is the reason why cyclodextrins have attracted much interest in many fields, especially pharmaceutical applications: because inclusion compounds of cyclodextrins with hydrophobic molecules are able to penetrate body tissues, these can be used to release biologically active compounds under specific conditions." [cite^5  doi:10.1016/S0378-5173(98)00382-2 ]

Potentially, yes

Starting with maybe 5mg loperamide, going up by 3mg every half hour to full hour until effects are noticed.
With respect to your previous doses possible 1/4 as much that would have been taken without complexing.

And do for for fucks sake do some reading up before trying this on the potential POISON that it might metabolise to, appears to do so, in organisms W/ compromised BBBs.

Duly noted (will remove the bluelight post now), figured that it was a half-way 'safe' thing to be going about doing considering the money put into this chemical when getting developed by (wasn't it Janssen looking for something better than Fent or similar?). Well this does appear to be pretty much unknown... fuck?

I have no intention of trying to spread this shit into the wind if it works due to the addicts who are already everywhere but it would be very interesting to know that it could potentially work. Time to do some more reading it looks like.

But what you are saying unintentionally is that this would not compromise the BBB? The complexation by my understanding simply encapsulates the molecule, why would this do anything to the BBB?

I know this does not make it safe in any way from the dangers of the molecule itself crossing the BBB but wouldn't this method only be a means to have loperamide cross the BBB?

I am not going to be doing any experimentation without first reading up on this very much, it would help to know where to begin but I will not be one of those guys unless I have to. I just want to contribute a bit to the community and this seemed an interesting way but I sure as fuck don't want to spawn a generation of OTC junkies or OD myself.

IIRC, the Hydroxypropyl variant is well tolerated. Other beta-cyclodextrines are not. I don't think that HPBCD will help anything get past the BBB because HPBCD is probably too large to be transported (if the loperamide-HPBCD complex is IV'd) and it won't be diffused across the membrane. The reason loperamide isn't CNS active is that it gets removed rapidly by the p-glycoprotien pump after it gets across the BBB.