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Author Topic: 1st great combo + 2nd great combo = EPIC COMBO !  (Read 104 times)

Oerlikon

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1st great combo + 2nd great combo = EPIC COMBO !
« on: March 25, 2012, 05:56:56 PM »
Age: 21

Weight: 100 kg

First combo:
Dosage of Maclobemide (Aurorix): 150mg morning dose (daily)

Dosage of buprenorphine: 1,5mg

Dosage of chemical tramadol: 250-300mg (redosing)

Dosage of amisulpride: 100mg

Second combo:(after 12h)
Dosage of Maclobemide (Aurorix): 150mg night dose (daily)

Dosage of MDMA.HCl: 200mg+100mg after 1/2 hour

Dosage of GBL: 2,2 ml


Desired effects: Amisulpride boosts opiate euphoria and body high to the new dimension!
It makes opiate high very long lasting. Aurorix is said to enhance opioids.

Intensity: VERY STRONG and different quality of the body high and constant waves of euphoria.
After taking second combo intensity of the pleasant body high was beyond comprehension!

Source:pharmaceutical,homemade(MDMA),OTC (GBL)

Background:
I developed a bit of tolerance to the opiates,so doses I took are about 2x of what opiate naive person should use.
I usually use this combo when I need to endure a long bus rides.

Experience:
First combo gave me a very long lasting opiate buzz with constant waves of euphoria that lasted longer than
any other high I ever experienced. Served me great to endure that damn bus ride! I redosed just a bit after 10h and after 12h I was going out with my friends. Just before that I took my second daily dose of Aurorix and then 300mg MDMA. High was really nice and synergy between opiate and MDMA buzz was great. I got an idea to throw some GBL into that. GREAT IDEA! INSANE EUPHORIA and body high from all the synergic action was beyond something I can express with words. I highly doubt that anyone else here felt such and amazing body high,ever.
Closest thing comparable is having sex when you just start cumming! FOR 6 FUCKING HOURS!!! ;D
My whole body was tingling and felt easy as feather,I was hovering and had feeling that I will
faint from euphoria! As soon as I closed my eyes I was dreaming(awake) and "sailing" on the waves of bliss not feeling my body at all. To make things even more interesting,300mg MDMA lasts me 3-3,5h,now,thanks to Aurorix it lasted me at least 6h AS STRONG as firs hour on straight MDMA,all that w/o any suplemental dose! There was no crash just a gentle coming down to the baseline that was welcomed by remaining opiate comfort. Sleeping was shallow but very enjoyable and everything feels so soft. No sweats or anything like that like after normal night of
rolling. Day after feels great too.
 
Summary:
Great combo,dose of the aminsulpride will need some titration until you find a dose that suits you but I don't recommend going over 150mg. MDMA and GBL tend to give most amazing body high but throwing in some opiates was simply AMAZING beyond what words can express. I definitely recomend this combo to anyone but please,be carefull with doses.
Welcome to my lab,
where you can choose your own dreams!

RoidRage

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Re: 1st great combo + 2nd great combo = EPIC COMBO !
« Reply #1 on: March 26, 2012, 12:10:49 AM »
No expert at pharmacology here, but I always though amphetamines (and many others substances) and a MAOI were a potentially fatal combo and definitly NOT recommended?!

dream0n

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Re: 1st great combo + 2nd great combo = EPIC COMBO !
« Reply #2 on: March 26, 2012, 04:58:20 AM »
You have a point!  Careful now.
off to bigger and better things - don't worry I will visit from time to time

fresh1

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Re: 1st great combo + 2nd great combo = EPIC COMBO !
« Reply #3 on: March 27, 2012, 05:41:04 AM »
hey Oerlikon amigo thats a most unusual combination of drugs you are taking there! 

 I'm not having a go at you here, but please bee careful with these types of combinations!

   Some of them i.e. buprenorphine and tramal are virtually 'exclusive' in that the bupes much higher binding affinity would  exclude the tramadol from attatching to any opiate receptors BUT would still retain its SNRI behaviors, so...

  when an MOAI is included, the disruption to your seretonergic system would be severe!

 Toss in some MDxx and WOW....man I am surprised it was SO enjoyable! for as RR suggests...

Quote
I always though amphetamines (and many others substances) and a MAOI were a potentially fatal combo and definitly NOT recommended?!
  they most definately can be!    http://en.wikipedia.org/wiki/Serotonin_syndrome

 the potential for some type of seretonin poisoning here is high so bee careful matey!
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Oerlikon

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Re: 1st great combo + 2nd great combo = EPIC COMBO !
« Reply #4 on: March 27, 2012, 11:11:49 PM »
Read a bit more about Maclobemide,it's very special,reversible and not nearly as dangerous as older MAOIs.
It enhances and prolongs action of many drugs and I would not do that with other MAOIs!
Aurorix (Maclobemide) won't give you SS in normal doses with things like MDMA,I mean there is a
possibility but it's quite unlikely. But yeah,I told to friends around me if something goes wrong to remember word "serotonin syndrome" and tell that to ER.

SNRI effect of Tramadol in combination with Aurorix is probably to blame for my pupils being
huge instead of tiny as usual.

I only had problem mixing it with methylphenidate (unintentionally) but that shit gives me worst
possible comedown where I can only think how to kill myself or get the opiates/benzos ASAP!

I tough the same about bupe but no,tramadol and bupe are not exclusive,they have a beautifully synergy!
Actually Tramadol is only opioid I know that is not blocked by bupe even a little bit!
After being on the bupe binge for months my tolerance to "normal" opiates/morphians skyrocketed and
tramadol is only opioid that works as good as the first time I tried it!
Not only does it work but dose remained the same.
For example I need to take 150mg of morphine to feel like I took 30mg before playing with bupe
but 250mg (eq. dose of 25mg morphine) of Tramadol gives me the same high as before!
I can't explain that,but it must be due the affinity for the different subtypes of opioid receptors.

I have very unique preference when it comes to opiates.
For example codeine doesn't even work for me but bupe and tramadol (and of course,opium)
are mine all time favourites. Preffer them over morphine,morphine esters,oxcodone...
you know,things that normal people like!
I find that very practical since every junkie will give me his bupe or tram prescription for 100-200mg
of morphine or one of his "notorious" esters.  ;D

Yeah,I know,it's not a good idea to get high on bupe for a long time so I must find alternative full agonist
since WD of the bupe lasts for months!
Welcome to my lab,
where you can choose your own dreams!

fresh1

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Re: 1st great combo + 2nd great combo = EPIC COMBO !
« Reply #5 on: March 28, 2012, 04:56:17 AM »
thanx for they reply O'mon its clear to see you have done your research 8)  we just care about your balkan arse  ;D

Quote
After being on the bupe binge for months my tolerance to "normal" opiates/morphians skyrocketed and
tramadol is only opioid that works as good as the first time I tried it!
Not only does it work but dose remained the same.
veeery interesting ... fresh gets no opiate pleasure from tramal, but does noticed the SNRI 'up' together with a definite moderation of mood.
  Maybe the 'synergy' you were feeling as from this aspect of the drug ???
Quote
But yeah,I told to friends around me if something goes wrong to remember word "serotonin syndrome" and tell that to ER.
good to hear..tramal in itself can cause SS so combined with MDxx AND an MOAI (which inhibits monoamine oxidase, which metabolises seretonin, and if it cant, will result in elevated levels IF you're not careful..)
Meclobamide might be reversible BUT if it IS active in your system...see above ::)
Quote
Yeah,I know,it's not a good idea to get high on bupe for a long time so I must find alternative full agonist
since WD of the bupe lasts for months!
Yeah it can seriously FUCK with ones ability to appreciate ANY other opiate..strange drug, fresh has mixed feeling about it but wouldnt take it for longer than a few days a week....and the tramal STILL works?



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Oerlikon

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Re: 1st great combo + 2nd great combo = EPIC COMBO !
« Reply #6 on: March 29, 2012, 07:52:37 PM »
Yeah,I am thankfull,I know they are mentioning that not to brag but to help me not to kill myself! :)
Forgot to mention but...
My pupils were much bigger after taking 1st combo (They are usually pin-sized after taking tramadol)
so there DEFINITIVELY was some kind of Serotonin reaction.

I like both SNRI and opioid effect of the Tramadol,but SNRI part can make me too irritable and even aggressive
but opiate effect alone from 200mg of tramadol is FAR better than 20mg of pure morphine! (in quality more,but in strength too)
And not only does it works with bupe but it works MUCH better but you need to take bupe first.
Wait for hour or until you feel the strongest effect and than take Tramadol.  8)

Every drug works differently for every person. You either hate or love tramadol.
For example Sedit (or was it someone else here!?) mentioned that codeine is one of
the most euphoric opioids for him while I can't get anything from it apart from light disphoria and damn itch!
Welcome to my lab,
where you can choose your own dreams!

fresh1

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Re: 1st great combo + 2nd great combo = EPIC COMBO !
« Reply #7 on: March 30, 2012, 05:09:08 AM »
I'm really starting to wonder about tramadols so called 'opioid' nature, its binding affinity to most M receptors is negligable..

Quote
Tramadol is a centrally acting analgesic. Structurally it is not an opiate, but it exhibits some opioid characteristics. Like opioids it binds to µ receptors, although very weakly (binding
affinity is 10 times less than codeine and 6000 times less than morphine).2

The analgesic effects of tramadol are not completely reversed by the opioid antagonist naloxone and some patients who do not respond to codeine do respond to tramadol. This suggests that tramadol
has additional mechanisms of action. Tramadol inhibits reuptake of serotonin and noradrenaline and this probably contributes to its analgesic effects.

, tramadol 100 mg intramuscularly or intravenously was equivalent to 5–10 mg of morphine. However, in severe pain associated with either surgery or cancer, morphine was more
effective than tramadol and remains the drug of choice. In acute and chronic non-malignant pain, oral tramadol 100 mg is comparable to a combination of paracetamol and codeine (1000 mg/60 mg)..

and here's the scary bit (although fresh knows of no one who has had seizures....but)

Quote
Seizures have been reported with tramadol at normal doses. ADRAC has received 66 reports involving convulsions and in 27 tramadol was the sole suspected drug. Tramadol should be avoided in
patients with epilepsy and used cautiously in patients taking medications which lower the threshold for seizures, including tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs),
major tranquillisers, bupropion and opioids. Other serious adverse effects include hallucinations, hypertension and hypersensitivity reactions.

and here's a direct reference to meclobamide...

Quote
Interactions may involve enhanced drug activity at receptor sites. A severe serotonin syndrome may occur when tramadol is combined with other drugs which also increase serotonin
activity.6 Such drugs include SSRIs, moclobemide and other monoamine oxidase inhibitors, tricyclic antidepressants, sibutramine, St John’s wort,
lithium and pethidine.1,7 ADRAC has received 35 reports of serotonin syndrome in association
with tramadol, usually in combination with other serotonergic drugs

http://www.australianprescriber.com/magazine/27/2/26/7/

Quote
For example Sedit (or was it someone else here!?) mentioned that codeine is one of
the most euphoric opioids for him

poor sedit always gets nailed with this comment but IIRC I believe he actually said the OPPOSITE!

At the end of the day I dont doubt you know what you are doing Omon...you were already aware of the possibilities (which MANY folks aren't!)

I just thought this info would balance out a bioassay which almost screams to other peeps "DO THIS" which (imo) is maybe not such a good idea, when discussing drugs many people have fairly easy access to.

Hope its all good at your place Omon :)

« Last Edit: March 30, 2012, 05:22:27 AM by fresh1 »
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