I have a three year old Sceletium joubertii plant that was grown from seed. Very beautiful and easy to grow, but the kougoed I've prepared from some of the fermented plant material isn't very potent. I think S. tortuosum is to be preferred.

I've heard Delosperma cooperi is a good one that grows like a weed and contains some o that good stuff  .   Vesp do you know any species that contain both mesembrine and dmt?  bet that would be quite the addition to an ayahuasca brew. 

I've really enjoyed kanna the times I have tried it, I found it to be the loveliest of marijuana potentiators and on top of that It gets rid of  any tired groggy feelings leaving you with just a relaxed energetic high when their mixed and that sweet taste so good.  Its sad to hear that it may be being over exploited but I could believe it what with the legal highs industry having found out about it.  Cool to hear their easy to grow, gonna go find my self some Sceletium tortuosum seeds and see if I cant have myself another little nice addition to my indoor garden. 

Vesp do you know any species that contain both mesembrine and dmt?  bet that would be quite the addition to an ayahuasca brew. 

It would be a quote the addition indeed - likely hurting you very badly and maybe leading to death.  Mixing a MAOI with an SSRI (mesembrine) leads to serotonin syndrome and I am sure other issues as well.

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Vesp do you know any species that contain both mesembrine and dmt?  bet that would be quite the addition to an ayahuasca brew. 

It would be a quote the addition indeed - likely hurting you very badly and maybe leading to death.  Mixing a MAOI with an SSRI (mesembrine) leads to serotonin syndrome and I am sure other issues as well.

Oh snap I had completely forgotten that it was an ssri Yeah definitely would be a horrible idea to mix with an MAOI.  super dumb statement on my part.  What effects would an SSRI have on smoking dmt? would a "jungle spice" (full alkaloid extract) made from a plant that contains both be any good?  mesembrine has that super nice PDE4 inhibitor that keeps you from feeling tired.  or am I being dumb again and don't ssri's cancel out hallucinogens?

Depends on the MAOI, plenty are reversible, such as the harmala alkaloids and moclobemide, they are what is known in the pharmacology trade as 'RIMAs' I.e 'reversible inhibitors of monoamine oxidase (type) a

There are two forms of MAO in humans, MAOa and MAOb, MAO-a is present in the periphery, and preferentially guzzles up (nor)adrenaline and serotonin, whilst the one present in the brain is MAOb, which has a bit more in the way of good taste, and prefers to munch up dopamine. (although on reading the wiki article, which contradicts what I have learned elsewhere, both types attack DA equally, and MAO-b preferentially trashes phenethylamine and trace amines, the endogenous ligands for the TAARs (such as for instance, the iodothyronamines, and quite possibly DMT) I thought I should include this to make sure no misinformation is given. Although of course, wiki isn't the best source in the world...but that info should not go unposted IMO.

Although in the same article, it then goes on to state, that MAO-b DOES preferentially chomp up DA and phenethylamine (and of course it still deaminates trace amines)



An example of the former (noncompetitive, I.e irreversible, competitive inhibitors compete with the enzyme's substrate, when it is 'really needed' to put it in simplistic terms, the subsrate can kick off the inhibitor to be broken down, noncompetitive inhibitors, also sometimes known as suicide inhibitors bind, and stay bound, meaning that when for instance, acetylcholine encounters the pharmaceutical drug galantamine, a competitive acetylcholinesterase inhibitor, to some degree, it gets pushed off AChE allowing the acetylcholine to be broken down and then recycled, whereas with a noncompetitive inhibitor such as tabun (early nerve agent, development wise, sarin (a G-series nerve agent), VX (a V-series nerve agent), GV, a hybrid between the G and V series, and the oh-so-bastardly new novichok (meaning 'newcomer' in russian, and pronounced 'no-wee-shok'), newer, 4th generation binary agents that are at least 10x the lethality of VX, and are solids, dispersed as powder, possibly as suspensions in volatile solvents, etc. depending on what kind of battle tactics those vicious russki buggers are using at the time, those are all noncompetitive, irreversible acetylcholinesterase inhibitors, and are highly toxic (no shit sherlock, thats the entire point of most chemical weapons :D:P)

As an overall, general rule of thumb, although I am sure there are exceptions, enzyme inhibitors containing reactive functional groups are likely to turn out to be noncompetitive. such as that nasty looking hydrazine in phenelzine, and isoniazide for example or that rather strained cyclopropane  ring in tranylcypromine. If such a reactive functional group is present in an enzyme inhibitor, that can end up forming a covalent bond with its target enzyme, an irreversible, noncompetitive inhibitor is pretty likely. And these are also likely of far greater toxicity in vivo than are competitive (reversible) inhibitors. With such a covalently bonding inhibitor the body has to synthesize new enzyme before the work of said enzyme can begin again. This takes time, explaining the long washout period between taking something like isoniazid and either being put on other antidepressants, or eating certain foods, I.e those are high in the dietary pressor amine tyramine, normally chopped a new arsehole by MAO.

seretonin syndrome. gag. puke. twitch, die.