Hi all, this is a cross post from another forum so forgive me if you've seen this already. Hoping to get some input on the situation.
A buffered performic acid synthesis of MDP2P was performed in DCM on a small amount of isosafrole. The reaction was worked up per the literature except HCl was used instead of H2SO4 to form the ketone. After distillation, two products were noted on TLC (5% EtOAc in Toluene). The spots have a very similar RF. The primary spot (MDP2P) is about RF .54 with the major side product being around 0.58.
Separation by column chromotography was fruitless due to the very similar RF values. Judging by the intensity of the spot under UV light there is a fair amount of whatever this stuff is. Is this likely MDP1P? I'm very hesitant to put this through a mass spec, but my curiosity may get the best of me.
I'd love to here any thoughts on likely side products. The smell and color are spot on. The only thing I can come up with is MDP1P
A buffered performic acid synthesis of MDP2P was performed in DCM on a small amount of isosafrole. The reaction was worked up per the literature except HCl was used instead of H2SO4 to form the ketone. After distillation, two products were noted on TLC (5% EtOAc in Toluene). The spots have a very similar RF. The primary spot (MDP2P) is about RF .54 with the major side product being around 0.58.
Separation by column chromotography was fruitless due to the very similar RF values. Judging by the intensity of the spot under UV light there is a fair amount of whatever this stuff is. Is this likely MDP1P? I'm very hesitant to put this through a mass spec, but my curiosity may get the best of me.
I'd love to here any thoughts on likely side products. The smell and color are spot on. The only thing I can come up with is MDP1P
Chemical markers from the peracid oxidation of isosafrole.pdf
