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Author Topic: Conversion of 4-HO-DMT to 4-AcO-DMT and others?  (Read 123 times)

bluecurry

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Conversion of 4-HO-DMT to 4-AcO-DMT and others?
« on: September 26, 2009, 09:10:32 PM »
So I was wondering if this could be accomplished easily with acetyl chloride (or GAA and Thionyl chloride).

Also, what would the results be of combining 4-HO-DMT with propionic anhydride? 4-Propionyl-DMT? I have no clue and come to you.

thanks

Vesp

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Re: Conversion of 4-HO-DMT to 4-AcO-DMT and others?
« Reply #1 on: September 26, 2009, 11:49:03 PM »
Next time you post such a question please provide references and show that you have at least attempted to find information that may help confirm your suspicions about a reaction such as this one.
Look what I have found in just a sort time about the compound you are interested in...
http://en.wikipedia.org/wiki/O-Acetylpsilocin
http://www.erowid.org/chemicals/4_acetoxy_dmt/
http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=6535
http://www.bluelight.ru/vb/showthread.php?t=262868&highlight=4-AcO-DMT/

The second to the last one gives a synthesis, I do believe.
I also think the prop derivative of the aceylating agent used in the synthesis could probably be used to form the 4-Propionyl-DMT.
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bluecurry

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Re: Conversion of 4-HO-DMT to 4-AcO-DMT and others?
« Reply #2 on: September 27, 2009, 03:06:42 AM »
Thank you vesp.

I had actually found some of the answers to my questions after posting however I was still curious about the possibility of 4-Propionyl-DMT. I have read that dipropanoylmorphine is longer lasting and more potent by weight than diacetylmorphine so that gives reason to my interest.

but again, thank you for linking me, I'll be sure to do more thorough research prior to posting in the future.

Vesp

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Re: Conversion of 4-HO-DMT to 4-AcO-DMT and others?
« Reply #3 on: September 27, 2009, 05:49:03 PM »
Yes, please let us know if you find anything else out about either of these aceylated compounds. This does look like an interesting compound no doubt. :)
Especially if you find a more OTC method that doesn't involve anhydrides, and acyl chlorides.
Although there is a thread here that makes propanoic anhydride sound fairly easy to make via distillation of a pyrosulfate and propanoiate salt.

dipropanoylmorphine and 4-P-DMT probably can't really be compared to each other all that well, however I think you have the right idea.  the 4-P-DMT might cross the BBB more easily making it more effective in one way or another. I bet it would cross the BBB better then 4-OH-DMT considering how it would be less polar.
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Abraxas

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Re: Conversion of 4-HO-DMT to 4-AcO-DMT and others?
« Reply #4 on: January 27, 2010, 03:57:43 AM »
What a waste of 4-OH-DMT...

Sedit

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Re: Conversion of 4-HO-DMT to 4-AcO-DMT and others?
« Reply #5 on: January 27, 2010, 05:01:54 AM »
Explain to us less fortunate souls why the possiblity of making it cross the Blood brain barrier and increasing potancy is a waste please. Else all thats getting wasted is out time and brain cells.
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shroomedalice

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Re: Conversion of 4-HO-DMT to 4-AcO-DMT and others?
« Reply #6 on: January 27, 2010, 05:36:47 AM »
psilosin will cross the brain barrier to my knowlage and if you read shulgins reports he agrees.

how ever the major benifit to making the acetyl of psilocin is that the salt then stores for a longer time with
out degradation.

Abraxas

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Re: Conversion of 4-HO-DMT to 4-AcO-DMT and others?
« Reply #7 on: January 27, 2010, 06:00:03 AM »
hmm I didnt read this thread properly, thought was about conversion to 4AcO-DET which IMO would indeed be somewhat analogous to making meth from mdma... cant say I know what 4-AcO-DMT is like yet still I find it hard to beloeve it wouldnt be qualitatively inferior to psilocin... Always great to see application of new synth tho... just ignore me Im naturally defensive of 4-ohdmt dnt like to see it hurt :-X

Sedit

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Re: Conversion of 4-HO-DMT to 4-AcO-DMT and others?
« Reply #8 on: January 28, 2010, 04:12:56 AM »
No you read it correctly but the misunderstanding may come from the fact that the acetylated version is more then likely less prone to metabolism forming 4-OH-DMT invivo simular to heroin from morphine type biochemistry. Im sure Enkidu or Mr Murphy could elaborate if this is indeed the case but I would have to assume it would be.
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