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Author Topic: Cinnamedrine (n-cinnamyl ephedrine) - Potential for novelty?  (Read 119 times)

bluecurry

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Cinnamedrine (n-cinnamyl ephedrine) - Potential for novelty?
« on: September 28, 2009, 08:05:50 PM »
I found this while browsing my toxicology book. According to the book "there are reported incidences of abuse and dependence of preparations containing N-cinnamyl ephedrine".

Most preparations are in the form of the levo isomer (much like l-methamphetamine is in vicks inhalers), so I wonder if A) how one would go about synthesizing this and b) what it's abuse potential would be like (especially the dextro isomer).

I can't find too much on it, there are references to it but not much else...

bluecurry

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Re: Cinnamedrine (n-cinnamyl ephedrine) - Potential for novelty?
« Reply #1 on: September 29, 2009, 01:20:03 AM »
http://jpet.aspetjournals.org/cgi/content/abstract/76/3/295
Quote
Cinnamylephedrine (d, l, and dl) is about ten times as potent a surface anesthetic as cocaine when tested by the rabbit's cornea method. Irritation occurs when concentrations of one per cent or greater are used.

It's also said to be a muscle relaxant albeit the company that produces midol (where this was originally part of the formula) was sued for not citing proper references to support the claim that cinnamedrine was a muscle relaxant.

Through possible oxidation, could this lead to cinnamethcathinone?

maybe theres nothing to this.

Vesp

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Re: Cinnamedrine (n-cinnamyl ephedrine) - Potential for novelty?
« Reply #2 on: September 29, 2009, 01:25:34 AM »
Well, it is the levo form, right?
That may make it fairly useless, but maybe not. Just something to keep in mind...
I think the double bond would likely be oxidized before anything else, and cause problems forming anything really novel out of it such as the compound you mentioned.

It isn't OTC is it?
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bluecurry

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Re: Cinnamedrine (n-cinnamyl ephedrine) - Potential for novelty?
« Reply #3 on: September 29, 2009, 03:38:26 AM »
well the d/l form isn't OTC as far as I know.

the Levo form was OTC in midol at around 15mg per pill a while back before the company was sued for misrepresenting the compounds efficacy. The compound isn't watched as far as I know and has legitimate uses in relieving PMS symptoms so I doubt it would be hard to come across. I haven't been able to find synthesis information for it either.

The reason I mention this substance is because it supposedly can cause muscle relaxant effects and is an effective local anesthetic.

Naf1

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Re: Cinnamedrine (n-cinnamyl ephedrine) - Potential for novelty?
« Reply #4 on: September 29, 2009, 04:18:42 AM »
I dont know about these guys and what they get up too with their smooth muscle relaxants ::)

N-substituted phenyl alkylol amines
http://www.freepatentsonline.com/1959392.html
« Last Edit: September 29, 2009, 04:37:15 AM by Naf1 »

Happyman

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Re: Cinnamedrine (n-cinnamyl ephedrine) - Potential for novelty?
« Reply #5 on: September 29, 2009, 05:02:19 AM »
Don't see it on Froogle...
Have fun finding someone to waste good ephedrine on it.

Hypothetically couldn't you make the methcathinone/methamphetamine first and then add the cinnamyl group?

bluecurry

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Re: Cinnamedrine (n-cinnamyl ephedrine) - Potential for novelty?
« Reply #6 on: September 29, 2009, 07:21:20 PM »
Thanks Naf!

happyman, I would imagine that it would be possible to add the cinnamyl group during the process of making meth via P2P (is what I've assumed judging by the patent posted). I don't know if it would be possible to add it after being made, but I could be wrong.

Quote from: Canadian CSA
Cathinone ((–)–?–aminopropiophenone) and any salt thereof

So would this mean that making a cinnamyl methcathinone would not fall under the canadian CSA?

Quote from: Canadian CSA
Methamphetamine (N,?-dimethylbenzeneethanamine), its salts, derivatives, isomers and analogues and salts of derivatives, isomers and analogues
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