Styphnate here.

I'm new to the whole scene, hive was before my time.  Been looking around here for a little while, posting occasionally.  Nice little place you guys got here.

I'm more into chemistry than anything else, not so much the drug scene.  Not that I'm opposed to it or anything, just rather stay legal(ish).  I'm cautious like that.

Not to say I'll be avoiding it like the plague.  One synthesis I'm working on is 2,5-dimethoxy-4-nitrobenzaldehyde, and I'm also looking into endocannabinoids.

Anyway, that's all for now.  I'd like to thank Vesp for making this place a reality.  And Sedit, as I've always found his experiments very interesting, both here and on SM.

Thank you very much for the compliment Vesp.  Your words warm my heart.   

And as for the ish part, I suppose I'm exagerating.  I think the only laws I've broken so far involve improper storage of flammables, which has since been resolved.

Mostly just the basic stuff.  You know, nitric acid, diethyl ether, bromine, inorganic salts, etc.  Tried a modified small scale version of Rhodium prep for acetic anhydride using silver acetate instead of sodium acetate (way too expensive for large scale, true, but also way easier to dry than sodium acetate as it doesn't form a hydrate), but it failed, mostly due to pyrolysis of silver acetate.  Now i've got a nice test tube lined with silver to show for it though, lol .  Also into biodiesel though, and I work with a lab on campus that makes it from used cooking oil.

The nearest big thing I can see in the future for me is ethyl bromide prep.  I plan on using the method presented by Gatterman.  I know there are a couple on this site, and I've got nothing against them, but I prefer Gatterman's method, as it seems like less work given that reaction and distillation take place at the same time.  Course, I have to wait for my condensor and distillation apparatus to arrive (well, actually I have to order them first--you see, I've been getting by on very little equipment so far), and also probably for midterms to pass by too.

Anyway, hope I can be of use to the community.

Styphnate

Actually, I have already synthesized a few grams of oleamide.  The synthesis is even easier than that, as you can simply react the acid with aqueous ammonia to form the ammonium salt, then heat in an evaporating dish until all the water is driven off, then transfer to a crucible and heat for a little while more.  I'll provide a write-up in the next few days.

Although I'm looking more into derivatives of arachidonic acid.  Do you think I can prepare more complex amides by heating concentrated amine solution with the methyl ester in good yield with high purity?  Because to me it seems like all that heat would be trouble.  ARA is sensitive stuff, easy to oxidize.  I was looking more into peptide coupling reagents, i.e. tosyl chloride or isobutyl chloroformate.  I'm also having a little trouble sourcing ARA, best I've found so far is bodybuilding suppliments, as I can't find sources for the pure oil or cultures of the algea/fungi that produce it.  But I guess all this belongs in the anandamide thread.

The most promising analogue IMHO, and the one I'm currently working on atm, is methanandamide, which is resistant to FAAH (specificly I've been designing a chiral synthesis for S-2 Methanandamide, binding affinity 26nM).  Others I've looked into are the chloroethyl and cyclopropyl amide derivatives of ARA, which are vastly more potent, but are not resistant to FAAH, and as such would need an FAAH inhibitor (which I have also been considering synthesizing, specifically palmitylsulfonyl fluoride, but the synthesis looks like a lot of trouble and I have only a patent to go by).  The metabolite of tylenol, arachidonyl p-phenolamide, is something that has been on my mind, as it would certainly decrease FAAH activity, but I haven't seen any references to particularly strong inhibition of FAAH or CB-1 affinity that make it seem worthwhile.  I've also been looking into other methods of procuring ARA, but the total synthesis of it is an unbelievable PITA.  And yes, I saw the thread on endocannabinoids, but it wasn't much help.

Of course, I have references to all this which I will post if you want along with the write-up monday or tuesday.

I assume you've never heard anything about a report of doing just it, or done it yourself?

Nope.  I can't promise a bioassay, but if I find an opportunity when I don't have any remotely pressing engagements I'll give it a go, stepping up dosages slowly.

I would be interested in seeing writeups of your experiments related to endocannabinoids.