Author Topic: Morphine from Urine?  (Read 225 times)

no1uno

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Morphine from Urine?
« on: October 12, 2009, 12:59:10 AM »
Well, yuck is your first thought too huh?

Still, our body enzymatically demethylates codeine to morphine and that is about as far as it goes...

So the question is, if one were a moderate-high user of codeine, how much morphine would be in a weeks urine?

I'd expect that acid hydrolysis of the glucaronide (?) to give the free morphine/codeine salt - separation of the insolubles formed

Base with sodium hydroxide to get the morphenate (amongst a LOT of other crud), use an NP to remove any NP solubles

Hit the morphenate/etc. with Ammonium chloride to release the morphine base into fresh NP layer (which will take some codeine with it).


The initial acid/base should remove a LOT of non-phenolic crud that is NP soluble

The other phenolic constituents might be an issue

Any ideas?
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    There shallow draughts intoxicate the brain,
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Vesp

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Re: Morphine from Urine?
« Reply #1 on: October 12, 2009, 01:18:46 AM »
What is in human urine to begin with?
It would be good to know this, and their concentrations to figure out what would carry over in the morphine extractions, etc.

This is an interesting idea and I've heard of it being done with various drugs from natural and synthetic sources - but for morphine, is it really worth it?

I suppose it could be, but it seems like their would be easier methods by far.

However, I'd love to hear a success story with this!
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Naf1

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Re: Morphine from Urine?
« Reply #2 on: October 12, 2009, 01:26:29 AM »
LOL, I was going to bring this up in Jons morphine thread, but shame or dignity got the best of me! But since it has been brought up by someone else, you could actually recycle your drugs with cation exchange resin! Same as the kompot.

Efficiency and Sensitivity of Two Common Screening Methods for detecting Morphine in Urine
http://www.clinchem.org/cgi/reprint/19/7/753.pdf

You could literally make a crude extract and pass it over SA-2 cation exchange resin, and collect a good 90% yield.

Vesp

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Re: Morphine from Urine?
« Reply #3 on: October 12, 2009, 01:28:59 AM »
Quote
You could literally make a crude extract and pass it over SA-2 cation exchange resin, and collect a good 90% yield.

Do you mean 90% yield from the content the urine originally contained, or from the that consumed?
I assume the first?
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Naf1

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Re: Morphine from Urine?
« Reply #4 on: October 12, 2009, 01:43:47 AM »
I know a high percentage passes through untouched but I am not sure of the exact number. The 90% was in reference to the yield obtainable from the crude sample using the resin in question, so 90% of the morph from the urine extract (I never thought I would be talking about urine extracts!).

no1uno

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Re: Morphine from Urine?
« Reply #5 on: October 12, 2009, 01:58:30 AM »
What percentage demethylates?

Hang on, if this works, how the hell are they going to restrict access to precursors? You can only urinate so many times a week? :D
"...     "A little learning is a dang'rous thing;
    Drink deep, or taste not the Pierian spring:
    There shallow draughts intoxicate the brain,
    And drinking largely sobers us again.
..."

Prepuce1

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Re: Morphine from Urine?
« Reply #6 on: October 30, 2009, 03:41:04 AM »
I understand that urine was the first source of elemental phosphorus. Alchemists had entire neighborhoods saving it so that it could be boiled down in their labs.  :P Maybe we could kill two stones with one bird.

PP

jon

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Re: Morphine from Urine?
« Reply #7 on: November 04, 2009, 09:50:19 AM »
morphine is excreted as it's gluconuride conjugate so sorry.
well maybe not so sorry that's 3-gluconuride that would require workup (simple hydrolysis) or be biologically inert.
« Last Edit: November 04, 2009, 09:55:02 AM by jon »

Grenouille

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Re: Morphine from Urine?
« Reply #8 on: November 05, 2009, 02:22:04 AM »
Between 20 and 50% of mescaline makes it through intact as well. (Cochin J, Woods LA, Seevers MH (February 1951). "The absorption, distribution and urinary excretion of mescaline in the dog". J. Pharmacol. Exp. Ther. 101 (2): 205–9), not to mention a bunch of other stuff... (http://www.popsci.com/scitech/article/2008-02/your-sewer-drugs)

Screw processing just my own urine. Here's my plan:

1. Round up a shit-ton of ion exchange resin.
2. Rent a backhoe.
3. Process the contents of my neighborhood sewage pipe.
4. Enjoy  ;D (shortly before having my liver explode from the ridiculous amounts of every pharmaceutical known to man).

jon

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Re: Morphine from Urine?
« Reply #9 on: November 08, 2009, 04:04:49 PM »
you shoud utfse the are esy ways.
i op'ed on that work
austrain poppy seed for one.

shroomedalice

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Re: Morphine from Urine?
« Reply #10 on: November 22, 2009, 06:05:14 PM »
hehe its poppy season here and my god there are so many.
ive had to stop myself :) one week less a day now since I stopped my self.

it got to the point were I would just walk down the main street and pick them as I go.
just like a mushy straight in the mouth.

speed from piss
phosy from piss
urea from piss
hydratropic aldehyde from horse piss
a indepth discussion on the hive about drunks piss changing chemicals
and now this .

nope your all sick I say ill stick to eating the pods :)
 ;D

Sedit

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Re: Morphine from Urine?
« Reply #11 on: November 22, 2009, 09:24:01 PM »
Topic moved since no matter how sick it still relates to drug extraction. :P
There once were some bees and you took all there stuff!
You pissed off the wasp now enough is enough!!!