does anyone have any good ideas for seperating the morphine sulphate from the rest of the shit in MS contin type slow rrelease compounds?
unbinding MS contin
« on: November 30, 2009, 02:39:32 AM »
Pages: 1
Topic: unbinding MS contin (Read 196 times)
hypnos
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Vesp
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Re: unbinding MS contin
« Reply #1 on: November 30, 2009, 02:52:35 AM »
How is this pharmacology related?
What is MS contin?
What is MS contin?
Naf1
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Re: unbinding MS contin
« Reply #2 on: November 30, 2009, 03:34:44 AM »
Morphine Sulphate, Continus is the brand name.
(drug synthesis and extraction)
If you want this thread to stay here hypnos, you are going to have to fix it! Start with any info you can get regarding the pill in question and post it here, like the known excipients etc, etc. Are they time release? What type are they 100mg? And I am sure Vesp is about to move it to the relevant section, come on man you can do better than this! If you want someone to take the time to help, you should make it a little easier like I had to search for the pill insert information, and you have had that in your hand before you posted. You should add the type of pill MS Contin (what???), do you have a list of the excipients on hand?
(drug synthesis and extraction)
If you want this thread to stay here hypnos, you are going to have to fix it! Start with any info you can get regarding the pill in question and post it here, like the known excipients etc, etc. Are they time release? What type are they 100mg? And I am sure Vesp is about to move it to the relevant section, come on man you can do better than this! If you want someone to take the time to help, you should make it a little easier like I had to search for the pill insert information, and you have had that in your hand before you posted. You should add the type of pill MS Contin (what???), do you have a list of the excipients on hand?
Sedit
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Re: unbinding MS contin
« Reply #3 on: November 30, 2009, 04:24:20 AM »
Moved to Synthesis and extraction since it is focused on the extraction of drugs from a pills. In order to properly advise you on a means of extraction the inactives will need to be listed. Many here do not feel up to searching them down ourselfs so posting them will make it more apealling to answer.
hypnos
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Re: unbinding MS contin
« Reply #4 on: December 01, 2009, 12:29:14 AM »
sorry guys 
i thought it would be a generic type binder thar someone here would know about--i shall rectify this asap
i thought it would be a generic type binder thar someone here would know about--i shall rectify this asapno1uno
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Re: unbinding MS contin
« Reply #5 on: December 01, 2009, 08:06:28 AM »
Quote
MS CONTIN® (morphine sulfate controlled-release) Tablets are opiate analgesics supplied in 15, 30, 60, 100 and 200 mg tablet strengths. The tablet strengths describe the amount of morphine per tablet as the pentahydrated sulfate salt (morphine sulfate, USP). MS CONTIN® Controlled-release Tablets 15 mg, 30 mg, 60 mg, 100 mg, and 200 mg contain the following inactive ingredients: cetostearyl alcohol, hydroxyethyl cellulose, hypromellose, magnesium stearate, polyethylene glycol, talc and titanium dioxide.
MS CONTIN Controlled-release Tablets 15 mg also contains FD&C Blue No. 2, lactose and polysorbate 80.
MS CONTIN Controlled-release Tablets 30 mg also contains D&C Red No. 7, FD&C Blue No. 1, lactose and polysorbate 80.
MS CONTIN Controlled-release Tablets 60 mg also contains D&C Red No. 30, D&C Yellow No. 10, hydroxypropyl cellulose, and lactose.
MS CONTIN Controlled-release Tablets 100 mg also contains black iron oxide.
MS CONTIN Controlled-release Tablets 200 mg also contains D&C Yellow No. 10, FD&C Blue No. 1, and hydroxypropyl cellulose.
Taken directly from: here
Fortunately for you Morphine Sulfate is my long-term "drug of choice" and I am one of the multitude that have been fucking near killed by these tablets (pericarditis - curious disease, specific to abusers of this type of tablet - most junkies get endocarditis (inlet valve side), the crap in these tabs solidifies on the outlet side of your heart, causing swelling and eventual difficulty, eg. death).
Now, I'm not going to waste your time or mine dealing with the constitution of the colored coating - if you haven't worked out that it can be peeled off, then there is no hope for you
Now my beloved MS is only sparingly soluble in water (to the tune of about 60mg/mL - but in our terms that is enough), but that makes everyday denatured alcohol a real option for removing the alcohol soluble crud (cos the solubility of MS in alcohol is about 1:1000 - so 1mg/1L of dry alcohol, less if cold, which would make max losses if using even 95% alcohol pretty much fuck all).
That leaves us with the following list of gaaks (technical term) to research and find out the solubility thereof in various organic solvents
cetostearyl alcohol
hydroxyethyl cellulose
hypromellose
magnesium stearate
polyethylene glycol
talc
titanium dioxide
A bunch of these nasties are soluble in acetone to one extent or another (also other organic solvents), the trouble is I seriously hesitate to suggest heating organic solvents where junk is concerned - have a taste, on the nod, forget the pot on the stove.... disaster, fuck that DISASTER - let me look a little deeper IIRC I once came up with a system whereby using hot/cold ethanol and hot/cold water a decent extraction could be had (think I can remember that fucker?)
Magnesium Stearate, Cetostearyl Alcohol and the PEG (as is polysorbate 80) should be soluble in hot 95% ethanol, just going by feel here, but I don't recall being overly concerned about lactose (it is used to cut heroin, speed, etc.), it won't hurt anyone, talc and Titanium dioxide are immaterial.
That leaves just the hydroxyethyl cellulose, the hypromellose and depending upon the tablet the hydroxypropyl cellulose...
They WILL NOT be trivial to work around
Naf1
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Re: unbinding MS contin
« Reply #6 on: December 02, 2009, 03:20:05 AM »
Thanks for that No1uno!
On the Action of Organic Acids and their Anhydrides on the Natural Alkaloids.
C.R.A. Wright, D.Sc., Lecturer on Chemistry, St. Mary's Hospital Medical School, London. (Journal of The Chemical Society, Vol. 27 (1874), pp. 1031-1043.)
*Editor's Notes:
§ 3. Action of Acetic Acid on Morphine
When morphine is boiled for several hours with twice its weight of glacial acetic acid, and inverted condenser being attached, a large amount is converted into a substance related to morphine in the same manner as diacetyl-codeine is to codeine; by dissolving the product in water, adding ammonia, and shaking up with ether, an ethereal solution is obtained which yields a copious crystalline hydrochloride on shaking with hydrochloric acid; this hydrochloride is but sparingly soluble in cold water, but can be recrystallised from that menstruum when hot without change. The crystals contain C34H36(C2H3O)2N2O6.2HCl.6H2O.
When pure, neither the free base nor its salts give any coloration with ferric chloride; simultaneously with this base, however, there is formed a small quantity of a substance that does colour ferric chloride blue like morphine, but differs therefrom in being soluble in ether and in being precipitated by carbonate of soda in white amorphous flakes, soluble in excess of the precipitant; this substance does not seem to give a crystalline hydrochloride, and is apparently identical with the ß-diacetyl-morphine (2) described in § 5, i.e, is isomeric with the above base, yielding a sparingly soluble crystalline hydrochloride, which is accordingly designated [alpha]-diacetyl-morphine (2).
Its now known that the diacetyl morphine they refer to is actually 6-monoacetylmorphine. I have seen some references to esterification using silica chloride or cobalt chloride the cobalt chloride could be acquired from a pottery supplier? to boost the yields right up. When using traditional acetylation with acetic anhydride the alcohol at O-3 is the first to be acetylated and then the alcohol function at O-6 is finally acetylated, but with acetic acid the tertiary alcohol at O-3 does not participate! As only the secondary alcohol at O-6 is able to participate as only primary and secondary alcohols react via this mechanism (without elimination).
Fischer-Speier Esterification
Silica Chloride: A Versatile Heterogeneous Catalyst for Esterification and Transesterification
K. V. N. S. Srinivas, I. Mahender, Biswanath Das*
Abstract
Silica chloride is an efficient catalyst for esterification of carboxylic acids with alcohols as well as for transesterification of esters by both alcoholysis and acidolysis.
http://www.organic-chemistry.org/abstracts/literature/269.shtm
It would be a good bench mark to run this procedure as in the first reference
"When morphine is boiled for several hours with twice its weight of glacial acetic acid, and inverted condenser being attached, a large amount is converted into a substance related to morphine in the same manner as diacetyl-codeine is to codeine"
It would be preferential to use the free base as contacting with acetic acid is going to protonate the morphine and create the acetate salt. But I doubt using the HCl salt would matter.
On the Action of Organic Acids and their Anhydrides on the Natural Alkaloids.
C.R.A. Wright, D.Sc., Lecturer on Chemistry, St. Mary's Hospital Medical School, London. (Journal of The Chemical Society, Vol. 27 (1874), pp. 1031-1043.)
*Editor's Notes:
§ 3. Action of Acetic Acid on Morphine
When morphine is boiled for several hours with twice its weight of glacial acetic acid, and inverted condenser being attached, a large amount is converted into a substance related to morphine in the same manner as diacetyl-codeine is to codeine; by dissolving the product in water, adding ammonia, and shaking up with ether, an ethereal solution is obtained which yields a copious crystalline hydrochloride on shaking with hydrochloric acid; this hydrochloride is but sparingly soluble in cold water, but can be recrystallised from that menstruum when hot without change. The crystals contain C34H36(C2H3O)2N2O6.2HCl.6H2O.
When pure, neither the free base nor its salts give any coloration with ferric chloride; simultaneously with this base, however, there is formed a small quantity of a substance that does colour ferric chloride blue like morphine, but differs therefrom in being soluble in ether and in being precipitated by carbonate of soda in white amorphous flakes, soluble in excess of the precipitant; this substance does not seem to give a crystalline hydrochloride, and is apparently identical with the ß-diacetyl-morphine (2) described in § 5, i.e, is isomeric with the above base, yielding a sparingly soluble crystalline hydrochloride, which is accordingly designated [alpha]-diacetyl-morphine (2).
Its now known that the diacetyl morphine they refer to is actually 6-monoacetylmorphine. I have seen some references to esterification using silica chloride or cobalt chloride the cobalt chloride could be acquired from a pottery supplier? to boost the yields right up. When using traditional acetylation with acetic anhydride the alcohol at O-3 is the first to be acetylated and then the alcohol function at O-6 is finally acetylated, but with acetic acid the tertiary alcohol at O-3 does not participate! As only the secondary alcohol at O-6 is able to participate as only primary and secondary alcohols react via this mechanism (without elimination).
Fischer-Speier Esterification
Silica Chloride: A Versatile Heterogeneous Catalyst for Esterification and Transesterification
K. V. N. S. Srinivas, I. Mahender, Biswanath Das*
Abstract
Silica chloride is an efficient catalyst for esterification of carboxylic acids with alcohols as well as for transesterification of esters by both alcoholysis and acidolysis.
http://www.organic-chemistry.org/abstracts/literature/269.shtm
It would be a good bench mark to run this procedure as in the first reference
"When morphine is boiled for several hours with twice its weight of glacial acetic acid, and inverted condenser being attached, a large amount is converted into a substance related to morphine in the same manner as diacetyl-codeine is to codeine"
It would be preferential to use the free base as contacting with acetic acid is going to protonate the morphine and create the acetate salt. But I doubt using the HCl salt would matter.
Sedit
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Re: unbinding MS contin
« Reply #7 on: December 02, 2009, 03:53:44 AM »
Sorry I know im off topic and im not very good at Opiate chemistry but....
Why does everyone need Acetic anhydride exactly? Why can one not use Sulfuric acid catalyst in Glacial acetic acid? This works all to well for Isopropyl acetate as well as many other esters of acetic acid so why can it not be used here? Does it not work on phenols or is it a problem with the rest of the molecule?
Why does everyone need Acetic anhydride exactly? Why can one not use Sulfuric acid catalyst in Glacial acetic acid? This works all to well for Isopropyl acetate as well as many other esters of acetic acid so why can it not be used here? Does it not work on phenols or is it a problem with the rest of the molecule?
Naf1
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Re: unbinding MS contin
« Reply #8 on: December 02, 2009, 04:04:10 AM »
"Why does everyone need Acetic anhydride exactly? Why can one not use Sulfuric acid catalyst in Glacial acetic acid?"
Now you are on my page! 6-MAM is more potent than heroin!!!
Monoacetlymorphine wiki
http://en.wikipedia.org/wiki/Monoacetylmorphine
You dont even need the sulfuric acid catalyst, the acetic acid does the job! As stated in that quote from that 1800's paper;
"When morphine is boiled for several hours with twice its weight of glacial acetic acid, and inverted condenser being attached, a large amount is converted into a substance related to morphine in the same manner as diacetyl-codeine is to codeine"
When they wrote that in the 1800's they thought that a morphine molecule was actually two stuck together so heroin would be tetracetyl-morphine according to them. We now know that to be wrong but the diacetyl-codiene and morphine they speak of above is 6-monoacetyl codiene 6-MAC and 6-monoacetyl morphine 6-MAM. A large amount in converted into 6-MAM by merely refluxing with twice its weight acetic acid.
"Does it not work on phenols or is it a problem with the rest of the molecule?"
We actually dont want it to work on the phenol as that would produce O-3 MAM on acetylation, O-6 MAM is far superior. The Fischer type esterification will not proceed with tertiary alcohols (such as the hydroxyl group on a phenol) but will proceed with primary and secondary alcohols (such as the alcohol at O-6), acetylation it can proceed with acetic acid and phenols but generally a catalyst and more rigorous conditions are needed. So you can take advantage of that fact and produce a superior product with acetic acid (theoretically).
Now you are on my page! 6-MAM is more potent than heroin!!!
Monoacetlymorphine wiki
http://en.wikipedia.org/wiki/Monoacetylmorphine
You dont even need the sulfuric acid catalyst, the acetic acid does the job! As stated in that quote from that 1800's paper;
"When morphine is boiled for several hours with twice its weight of glacial acetic acid, and inverted condenser being attached, a large amount is converted into a substance related to morphine in the same manner as diacetyl-codeine is to codeine"
When they wrote that in the 1800's they thought that a morphine molecule was actually two stuck together so heroin would be tetracetyl-morphine according to them. We now know that to be wrong but the diacetyl-codiene and morphine they speak of above is 6-monoacetyl codiene 6-MAC and 6-monoacetyl morphine 6-MAM. A large amount in converted into 6-MAM by merely refluxing with twice its weight acetic acid.
"Does it not work on phenols or is it a problem with the rest of the molecule?"
We actually dont want it to work on the phenol as that would produce O-3 MAM on acetylation, O-6 MAM is far superior. The Fischer type esterification will not proceed with tertiary alcohols (such as the hydroxyl group on a phenol) but will proceed with primary and secondary alcohols (such as the alcohol at O-6), acetylation it can proceed with acetic acid and phenols but generally a catalyst and more rigorous conditions are needed. So you can take advantage of that fact and produce a superior product with acetic acid (theoretically).
hypnos
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Re: unbinding MS contin
« Reply #9 on: December 02, 2009, 04:40:34 AM »
OK!!! first,,sorry about the slack post...i think i was a bit brain dead when i wrote it--shit i know the answer!!! you dont rermove the binders,,you remove the morphine--water works fine,,just gotta use enough 
"dyslexic thinking rules" ( no i dont think i am dyslexic--its just i think dyslexically (back to front) sometimes :: 
however this thread has 'morphed' into one about morphine derivatives which is kinda where i was going with this anyway
thanx no1 for listing the 'gaak' as you call it--
6-mam sounds good-- i will be trying this out next week--also i want to try jons propionic anhydride variant
thanx naf juan (lol) for the inspiration
more to follow soonish
"dyslexic thinking rules" ( no i dont think i am dyslexic--its just i think dyslexically (back to front) sometimes :: however this thread has 'morphed' into one about morphine derivatives which is kinda where i was going with this anyway
thanx no1 for listing the 'gaak' as you call it--
6-mam sounds good-- i will be trying this out next week--also i want to try jons propionic anhydride variant
thanx naf juan (lol) for the inspiration
more to follow soonish
Naf1
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Re: unbinding MS contin
« Reply #10 on: December 02, 2009, 04:55:15 AM »
I want to address an issue regarding the time release component. I have come across patents that state that ion-exchange resins are and have been used as the time release constituent (as it would release the morphine only in basic medium(intestines, it would hold it in the gut and only release it in the alkaline intestinal tract), or being treated with suitable alkaline buffer solution). Have we got a name for the time release component of these Continus tabs?
As if it is ion-exchange resin, extracting Morphine base will boost the yield of morphine significantly. It will release any from the insoluble resin anyway, if that is what is being used.
"however this thread has 'morphed' into one about morphine derivatives which is kinda where i was going with this anyway"
Sorry, I could not wait.
As if it is ion-exchange resin, extracting Morphine base will boost the yield of morphine significantly. It will release any from the insoluble resin anyway, if that is what is being used.
"however this thread has 'morphed' into one about morphine derivatives which is kinda where i was going with this anyway"
Sorry, I could not wait.
Naf1
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Re: unbinding MS contin
« Reply #11 on: December 03, 2009, 02:47:46 AM »
Saturday, 13 November 2004
795
This presentation is part of: Undergraduate Posters I
Acetylation of Phenols
David A. Newbold and Justin B. Houseknecht. Centre College, Danville, KY
Morphine contains two alcohol groups, one phenolic and the other allylic. Acetylation of both alcohols provides the illegal street drug heroin. The selective acetylation of either alcohol has also been reported. We have determined that these conditions provide the same selectivity as observed for morphine with molecules lacking the structural complexity of morphine. Specifically, 1:1 mixtures of phenol and 2-cyclohexen-1-ol, when reacted with aqueous sodium bicarbonate and acetic anhydride, provided exclusively the acetylated phenol. Likewise, reaction of 1:1 mixtures of phenol and 2-cyclohexen-1-ol with acetic acid and catalytic sulfuric acid provided exclusively the acetylated allylic alcohol. We have further investigated the cause for the selectivity under the basic conditions by attempting to determine the mechanism by which phenols are acetylated. The selectivity mentioned above strongly suggests that the phenolic hydroxyl group is deprotonated prior to nucleophilic attack on the acetic anhydride, despite sodium bicarbonate being too weak to perform the deprotonation. Kinetic experiments have shown that the reaction rate is dependent upon pH, not the concentration of base, thereby clarifying the conundrum. The phenolic hydroxyl group reacts more rapidly under the weakly basic conditions than the allylic hydroxyl group because it is deprotonated by hydroxide prior to nucleophilic attack on acetic anhydride. The role of the base, sodium bicarbonate, is to increase the pH of the solution, thereby increasing the concentration of hydroxide ion.
http://acs.confex.com/acs/56serm/techprogram/P13571.HTM
I thought that was a nice experiment they conducted for us! The reason they use 1:1 mixtures of phenol and 2-cyclohexen-1-ol is because as you can see on a morphine molecule below there is a phenol group (red) and basically a 2-cyclohexen-1-ol (blue) so to simulate how the alcoholic groups of morphine are going to react, they simply added an equal mixture of phenol and 2-cyclohexen-1-ol, and proceeded with the esterification.
"reaction of 1:1 mixtures of phenol and 2-cyclohexen-1-ol with acetic acid and catalytic sulfuric acid provided exclusively the acetylated allylic alcohol."
Recommended methods for testing;
Opium, Morphine and Heroin
In addition, in Southwest Asia, there have been some recent suggestions that glacial acetic acid is being utilized for the acetylation of morphine. The esterification of simple alcohols using glacial acetic acid and an inorganic acid catalyst is known, and has been used for large scale commercial productions.[20] The synthesis of 6-acetylmorphine via the reaction of morphine with glacial acetic acid was published by Wright[21] in 1874, and in 1984 Sy et al[22] duplicated the work of Wright. Niether produced heroin in significant yields, but in both cases 6-acetylmorphine was prepared in approximately 50% yield. Recently, using far stronger dehydrating agents than either of the previous works, an attempt was made to produce heroin from morphine using glacial acetic acid, with essentially identical results to these earlier works in that the primary product was 6-acetylmorphine and/or degradation products.[23]Although it is not beyond the realm of what is possible, it seems unlikely that glacial acid acid will provide a suitable alternative to the classical choice of acetic anhydride for the acetylation of morphine.
20. Bender, M.L., Chem Rev 60 (1960)pp 53-113
21. Wright, C.R.A., J Am Chem Soc 27 (1874)pp1031-1043
22. Sy, W-W., By, A.W., Neville, G.A and Wilson, W., J Can Soc Forensic Sci 18 (1985)pp86-91
23. Cooper, D.A., unpublished
This paper is available at this government site(very good little book);
hxxp://www.unodc.org/pdf/publications/st-nar-29-rev1.pdf
795
This presentation is part of: Undergraduate Posters I
Acetylation of Phenols
David A. Newbold and Justin B. Houseknecht. Centre College, Danville, KY
Morphine contains two alcohol groups, one phenolic and the other allylic. Acetylation of both alcohols provides the illegal street drug heroin. The selective acetylation of either alcohol has also been reported. We have determined that these conditions provide the same selectivity as observed for morphine with molecules lacking the structural complexity of morphine. Specifically, 1:1 mixtures of phenol and 2-cyclohexen-1-ol, when reacted with aqueous sodium bicarbonate and acetic anhydride, provided exclusively the acetylated phenol. Likewise, reaction of 1:1 mixtures of phenol and 2-cyclohexen-1-ol with acetic acid and catalytic sulfuric acid provided exclusively the acetylated allylic alcohol. We have further investigated the cause for the selectivity under the basic conditions by attempting to determine the mechanism by which phenols are acetylated. The selectivity mentioned above strongly suggests that the phenolic hydroxyl group is deprotonated prior to nucleophilic attack on the acetic anhydride, despite sodium bicarbonate being too weak to perform the deprotonation. Kinetic experiments have shown that the reaction rate is dependent upon pH, not the concentration of base, thereby clarifying the conundrum. The phenolic hydroxyl group reacts more rapidly under the weakly basic conditions than the allylic hydroxyl group because it is deprotonated by hydroxide prior to nucleophilic attack on acetic anhydride. The role of the base, sodium bicarbonate, is to increase the pH of the solution, thereby increasing the concentration of hydroxide ion.
http://acs.confex.com/acs/56serm/techprogram/P13571.HTM
I thought that was a nice experiment they conducted for us! The reason they use 1:1 mixtures of phenol and 2-cyclohexen-1-ol is because as you can see on a morphine molecule below there is a phenol group (red) and basically a 2-cyclohexen-1-ol (blue) so to simulate how the alcoholic groups of morphine are going to react, they simply added an equal mixture of phenol and 2-cyclohexen-1-ol, and proceeded with the esterification.
"reaction of 1:1 mixtures of phenol and 2-cyclohexen-1-ol with acetic acid and catalytic sulfuric acid provided exclusively the acetylated allylic alcohol."
Recommended methods for testing;
Opium, Morphine and Heroin
In addition, in Southwest Asia, there have been some recent suggestions that glacial acetic acid is being utilized for the acetylation of morphine. The esterification of simple alcohols using glacial acetic acid and an inorganic acid catalyst is known, and has been used for large scale commercial productions.[20] The synthesis of 6-acetylmorphine via the reaction of morphine with glacial acetic acid was published by Wright[21] in 1874, and in 1984 Sy et al[22] duplicated the work of Wright. Niether produced heroin in significant yields, but in both cases 6-acetylmorphine was prepared in approximately 50% yield. Recently, using far stronger dehydrating agents than either of the previous works, an attempt was made to produce heroin from morphine using glacial acetic acid, with essentially identical results to these earlier works in that the primary product was 6-acetylmorphine and/or degradation products.[23]Although it is not beyond the realm of what is possible, it seems unlikely that glacial acid acid will provide a suitable alternative to the classical choice of acetic anhydride for the acetylation of morphine.
20. Bender, M.L., Chem Rev 60 (1960)pp 53-113
21. Wright, C.R.A., J Am Chem Soc 27 (1874)pp1031-1043
22. Sy, W-W., By, A.W., Neville, G.A and Wilson, W., J Can Soc Forensic Sci 18 (1985)pp86-91
23. Cooper, D.A., unpublished
This paper is available at this government site(very good little book);
hxxp://www.unodc.org/pdf/publications/st-nar-29-rev1.pdf
hypnos
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Re: unbinding MS contin
« Reply #12 on: December 16, 2009, 03:30:47 AM »
dont be sorry naf juan!!! go hard very interesting stuff
i wonder about the degradation of the morphine when it is boiled...IIRC it degrades at temps >80c so whats going to happen if you boil it?
very interesting stuffi wonder about the degradation of the morphine when it is boiled...IIRC it degrades at temps >80c so whats going to happen if you boil it?
hypnos
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Re: unbinding MS contin
« Reply #13 on: January 12, 2010, 11:46:24 PM »
hey naf juan i think you are digging up some REALLY worthwhile stuff here--after some consideration+retrospective thinking,,i reckon maybe up to 90% of the 'so called' heroin(beige powder) on todays market is,,in fact "6am" (6 acetyl morphine) but incompletely acetylated...can anyone help me with an accurate way of discerning what these powders may be? ghetto style that is--mp's maybe--any ideas?
Naf1
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Re: unbinding MS contin
« Reply #14 on: January 13, 2010, 12:33:14 AM »
"i reckon maybe up to 90% of the 'so called' heroin(beige powder) on todays market is,,in fact "6am""
It depends where it originated, if you are getting stuff born in the Golden Triangle which is very common in Australia, then it is most probably a majority 6-MAM. As they are known to use acetyl chloride, glacial acetic acid or acetic anhydride mixed with acetyl chloride to acetylate their morphine and as a consequence what is sold as Heroin that comes out of those areas is high in, or exclusively 6-MAM. Most other regions use acetic anhydride or produce acetic anhydride via ethylidine diacetate for example, which reacts via a mechanism which favors O3-acetylation, and that locant is acetylated first. For example in analysis of a sample of South American heroin (rare in Australia) it is fluffy and bright white, the two isomers of acetylmorphine never usually exceed more than 5% of the total weight of the sample and O-3-MAM is usually in predominance (showing Acetic Anhydride is being used probably in a professional lab somewhere). We would not see any Mexican produce whatsoever. Then you have the Golden Cresent, (the stans and turkey iran etc), which are also big Acetic anhydride users!
"Turkish-based traffickers and brokers operate directly and in conjunction with narcotic suppliers, smugglers, transporters, laboratory operators, drug distributors, money collectors, and money launderers in and outside Turkey. Traffickers in Turkey illegally acquire the precursor chemical acetic anhydride, which is used in the production of heroin, from sources in Western Europe, the Balkans, and Russia. During the 27-month period from July 1, 1999 to September 30, 2001, over 56 metric tons of illicit acetic anhydride were seized in or destined for Turkey."
A Fantastic Tale; Turkey, Drugs, Faustian Alliances & Sibel Edmonds
http://cryptome.org/turkey-tale.htm
Recomended methods for testing; Opium, Morphine and Heroin
United Nations Drug Control Program
http://sharebee.com/98ad3edc
A seriously good read!
It depends where it originated, if you are getting stuff born in the Golden Triangle which is very common in Australia, then it is most probably a majority 6-MAM. As they are known to use acetyl chloride, glacial acetic acid or acetic anhydride mixed with acetyl chloride to acetylate their morphine and as a consequence what is sold as Heroin that comes out of those areas is high in, or exclusively 6-MAM. Most other regions use acetic anhydride or produce acetic anhydride via ethylidine diacetate for example, which reacts via a mechanism which favors O3-acetylation, and that locant is acetylated first. For example in analysis of a sample of South American heroin (rare in Australia) it is fluffy and bright white, the two isomers of acetylmorphine never usually exceed more than 5% of the total weight of the sample and O-3-MAM is usually in predominance (showing Acetic Anhydride is being used probably in a professional lab somewhere). We would not see any Mexican produce whatsoever. Then you have the Golden Cresent, (the stans and turkey iran etc), which are also big Acetic anhydride users!
"Turkish-based traffickers and brokers operate directly and in conjunction with narcotic suppliers, smugglers, transporters, laboratory operators, drug distributors, money collectors, and money launderers in and outside Turkey. Traffickers in Turkey illegally acquire the precursor chemical acetic anhydride, which is used in the production of heroin, from sources in Western Europe, the Balkans, and Russia. During the 27-month period from July 1, 1999 to September 30, 2001, over 56 metric tons of illicit acetic anhydride were seized in or destined for Turkey."
A Fantastic Tale; Turkey, Drugs, Faustian Alliances & Sibel Edmonds
http://cryptome.org/turkey-tale.htm
Recomended methods for testing; Opium, Morphine and Heroin
United Nations Drug Control Program
http://sharebee.com/98ad3edc
A seriously good read!
Naf1
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Re: unbinding MS contin
« Reply #15 on: January 13, 2010, 12:51:15 AM »
In case you dont want go digging around that paper I linked, this will be the best way to determine the constitution of your sample without ruining it! (if you know what I mean )
Heroin (O3,6-Diacetylmorphine); melting point of Heroin base is 173*C
6-Acetylmorphine; melting point of 6-AM base is 200*C
3-Acetylmorphine; melting point of 3-AM base is 57 to 59*C
)Heroin (O3,6-Diacetylmorphine); melting point of Heroin base is 173*C
6-Acetylmorphine; melting point of 6-AM base is 200*C
3-Acetylmorphine; melting point of 3-AM base is 57 to 59*C
hypnos
- Dominant Queen
- Posts: 402
Re: unbinding MS contin
« Reply #16 on: January 13, 2010, 04:29:50 AM »
nafjuan i love your resources--thanx again for the data--keep up the good work and 'go shard!!' he he!
GlooZniffer69
- Larvae
- Posts: 8
Re: unbinding MS contin
« Reply #17 on: February 05, 2010, 01:22:34 PM »
QuoteMS CONTIN® (morphine sulfate controlled-release) Tablets are opiate analgesics supplied in 15, 30, 60, 100 and 200 mg tablet strengths. The tablet strengths describe the amount of morphine per tablet as the pentahydrated sulfate salt (morphine sulfate, USP). MS CONTIN® Controlled-release Tablets 15 mg, 30 mg, 60 mg, 100 mg, and 200 mg contain the following inactive ingredients: cetostearyl alcohol, hydroxyethyl cellulose, hypromellose, magnesium stearate, polyethylene glycol, talc and titanium dioxide.
MS CONTIN Controlled-release Tablets 15 mg also contains FD&C Blue No. 2, lactose and polysorbate 80.
MS CONTIN Controlled-release Tablets 30 mg also contains D&C Red No. 7, FD&C Blue No. 1, lactose and polysorbate 80.
MS CONTIN Controlled-release Tablets 60 mg also contains D&C Red No. 30, D&C Yellow No. 10, hydroxypropyl cellulose, and lactose.
MS CONTIN Controlled-release Tablets 100 mg also contains black iron oxide.
MS CONTIN Controlled-release Tablets 200 mg also contains D&C Yellow No. 10, FD&C Blue No. 1, and hydroxypropyl cellulose.
Taken directly from: here
Fortunately for you Morphine Sulfate is my long-term "drug of choice" and I am one of the multitude that have been fucking near killed by these tablets (pericarditis - curious disease, specific to abusers of this type of tablet - most junkies get endocarditis (inlet valve side), the crap in these tabs solidifies on the outlet side of your heart, causing swelling and eventual difficulty, eg. death).
Now, I'm not going to waste your time or mine dealing with the constitution of the colored coating - if you haven't worked out that it can be peeled off, then there is no hope for you
Now my beloved MS is only sparingly soluble in water (to the tune of about 60mg/mL - but in our terms that is enough), but that makes everyday denatured alcohol a real option for removing the alcohol soluble crud (cos the solubility of MS in alcohol is about 1:1000 - so 1mg/1L of dry alcohol, less if cold, which would make max losses if using even 95% alcohol pretty much fuck all).
That leaves us with the following list of gaaks (technical term) to research and find out the solubility thereof in various organic solvents
cetostearyl alcohol
hydroxyethyl cellulose
hypromellose
magnesium stearate
polyethylene glycol
talc
titanium dioxide
A bunch of these nasties are soluble in acetone to one extent or another (also other organic solvents), the trouble is I seriously hesitate to suggest heating organic solvents where junk is concerned - have a taste, on the nod, forget the pot on the stove.... disaster, fuck that DISASTER - let me look a little deeper IIRC I once came up with a system whereby using hot/cold ethanol and hot/cold water a decent extraction could be had (think I can remember that fucker?)
Magnesium Stearate, Cetostearyl Alcohol and the PEG (as is polysorbate 80) should be soluble in hot 95% ethanol, just going by feel here, but I don't recall being overly concerned about lactose (it is used to cut heroin, speed, etc.), it won't hurt anyone, talc and Titanium dioxide are immaterial.
That leaves just the hydroxyethyl cellulose, the hypromellose and depending upon the tablet the hydroxypropyl cellulose...
They WILL NOT be trivial to work around
This is not impossible from a former (gasp) meth cook's perspective. All of those adulterants are very common reaction inhibitors/binders in OTC allergy medicine.
Ethyl Acetate will cut most of these and a TCE wash would break most of them, but here I go digging my self in a hole. I don't know the solubilities of morphine, this post will be UPdated after I have done some more research, just wanted to make my first post here!(which after I looked, was my eighth, oops)
Also, you suggested acetone, but MEK is more effective with these particular binders.
Nice place, fellas!
hypnos
- Dominant Queen
- Posts: 402
Re: unbinding MS contin
« Reply #18 on: February 08, 2010, 01:49:23 AM »
hey matey welcome to a great forum,,its ALWAYS good to have others POV's regarding stuff there are no "definate" best ways for doing it
look forward to more of your ideas
look forward to more of your ideas
TooCold
- Larvae
- Posts: 32
Re: unbinding MS contin
« Reply #19 on: February 13, 2010, 08:07:03 AM »
Does anyone know the solubility of morphine sulfate in TCE, Acetone, or MEK? The most info I could found about the solubility of morphine sulphate in various solvents was in Oxy by Otto Snow. Here is his info:
sol. in 23 parts cold water,15.5 parts at 25C. 0.7 parts at 80C. Soluble in 452 parts alcohol at 25, 192 parts at 60C. Insoluble in chloroform and ether.
It seems to be that the 100mg tablets would be the best to go after since they are small and contain the least amount of inactives.
sol. in 23 parts cold water,15.5 parts at 25C. 0.7 parts at 80C. Soluble in 452 parts alcohol at 25, 192 parts at 60C. Insoluble in chloroform and ether.
It seems to be that the 100mg tablets would be the best to go after since they are small and contain the least amount of inactives.
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