Napthylaminopropane, discussion and likely synthesis outline.
First off before I start going into synthesis of this, pharmacology wise I am amazed that this compound isn't the slightest bit neurotoxic like amphetamine and most amphetamine analogs.
Ok, so the initial part will consist of a starting material of 2-naphthaldehyde, then a reaction of nitroethane and methylamine(from hexamine and hcl, byproduct is formic acid)
in isopropyl alcohol(MgSO4 dry maybe to get over 90% ?) to yeild N2NP.After that reaction, one could do a metal/acid reduction to the N2NP to yeild N2P.
After that a simple formic acid Leuckart reaction should work to give the end product.
Also one could do a one-pot synthesis using Naphthalene-2-carbonitrile as the starting material via MeMgI and NaBH4(http://www.erowid.org/archive/rhodium/chemistry/amphetamine.html)
Now back on the pharmacology information on this compound, it is a non-neurtoxic releasing agent of Serotonin, Dopamine and Norepinephrine.
EC50 values of 3.4 nM, 11.1 nM, and 12.6 nM. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=15677348
I'm sure this compound is relatively safe, I would be weary of a napthylene compound that has a 'beta' ketone(could metabolize to alcohol?) or alcohol(especially)
since it could possibly form a carcinogenic napthylene epoxide like the beta-blocker drug pronethalol.
Ok, so the initial part will consist of a starting material of 2-naphthaldehyde, then a reaction of nitroethane and methylamine(from hexamine and hcl, byproduct is formic acid)
in isopropyl alcohol(MgSO4 dry maybe to get over 90% ?) to yeild N2NP.After that reaction, one could do a metal/acid reduction to the N2NP to yeild N2P.
After that a simple formic acid Leuckart reaction should work to give the end product.
Also one could do a one-pot synthesis using Naphthalene-2-carbonitrile as the starting material via MeMgI and NaBH4(http://www.erowid.org/archive/rhodium/chemistry/amphetamine.html)
Now back on the pharmacology information on this compound, it is a non-neurtoxic releasing agent of Serotonin, Dopamine and Norepinephrine.
EC50 values of 3.4 nM, 11.1 nM, and 12.6 nM. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=15677348
I'm sure this compound is relatively safe, I would be weary of a napthylene compound that has a 'beta' ketone(could metabolize to alcohol?) or alcohol(especially)
since it could possibly form a carcinogenic napthylene epoxide like the beta-blocker drug pronethalol.