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Author Topic: herkinorin a damn interesting drug  (Read 186 times)

jon

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herkinorin a damn interesting drug
« on: December 31, 2009, 11:57:08 PM »

crazyboy

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Re: herkinorin a damn interesting drug
« Reply #1 on: January 01, 2010, 01:01:25 AM »
It is certainly interesting in that it is realted to salvinorin compounds and isn't an alkolid however it's complexity makes it's syntehsis a pipe dream and it's effects seem none too pleasnt:

Quote
it is likely that herkinorin will be found to produce similar effects to other ?-opioid selective agonists in vivo, such as analgesia and sedation, along with side effects such as nausea, itching, vomiting and respiratory depression which may be harmful or fatal.

mmmmm nausea, itching, vomiting, respiratory depression and sedation sounds like fun! Just kidding, it is a truly interesting compound but there isn't much experimentation any amatuer chemist could carry out with it.

Vesp

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Re: herkinorin a damn interesting drug
« Reply #2 on: January 01, 2010, 01:13:12 AM »
Probably pretty easy to make from salvinorins.. which the dried leafs of salvia divinorum is easy to buy in bulk especially B2B and extract...

All those effects are classical of other mu-opioids.. the best part here is that it sounds like herkinorin will not build up resistance. 
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jon

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Re: herkinorin a damn interesting drug
« Reply #3 on: January 01, 2010, 01:36:05 AM »
junkie's dream no tolerance no respiratory depression, constipation.
just selective mu affinity heres a pictoral of salvinorin a extration from leaf down to the pure stuff




http://www.erowid.org/plants/salvia/salvia_extraction4.shtml

next we ned to figure out deacetylation it has a sensitive lactone function the ester we want to snipp off is a keto ester
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