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Author Topic: Phenethylamine  (Read 241 times)

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Phenethylamine
« on: March 14, 2010, 09:15:20 AM »
Forgive me if this is a dumb question but why is phenethylamine not of more concern? First I read that it is easily oxidized to phenylacetic acid by the body and then I read that it is readily available as a supplement. Is there some reason why the body can turn it into phenylacetic acid with ease but we can not? Phikal has a pretty good entry on it going over various general things you can do with the molecule but nothing specific.

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Re: Phenethylamine
« Reply #1 on: March 14, 2010, 05:55:38 PM »
The same tech to oxidize the C-NH2 -> C-OH -> C=O -> COOH of phenethylamine would also be useful to oxidize (R)-1-phenylpropan-2-amine to 1-phenylpropan-2-one.

Let us know if you find something pretty concrete :)

Sodium bichromate/sulfuric/acetone has been ketone friendly in the past...

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Re: Phenethylamine
« Reply #2 on: March 18, 2010, 06:01:04 AM »
http://127.0.0.1/talk/index.php?action=dlattach;topic=785.0;attach=1671

There you are, something concrete. Phenethylamine should give phenylacetaldehyde which would probably be hard to keep from going all the way to phenylacetic acid. I just looked over the ref quickly but a simple increase of the excess oxidizer used for the primary amine oxidation should insure it.

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Re: Phenethylamine
« Reply #3 on: March 18, 2010, 06:12:32 AM »
Better make sure which PEA you are sourcing. 1-phenylethanamine would give acetophenone, if that is something that interests you. 2-phenylethanamine would be the winner for PAA. Cheap bulk supplements look like they are the wrong one. Let us know!
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