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Author Topic: Permonid Synthesis from Codeine  (Read 582 times)

Tsathoggua

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Re: Permonid Synthesis from Codeine
« Reply #20 on: April 04, 2012, 02:31:01 AM »
I meant actual desomorphine-D, rather than the unholy mixture of shite that must be in krokodil.

I dread to think what HI/RP reduction of codeine or chloro-codide (IIRC at least one process does use thionyl chloride, from batteries, then HI/RP.

Can't see the russian junkies doing a hypo reduction though, its probably because matchbook phos is easily available that it goes on. Matchboxes, iodine tincture/peroxide/acid...now where have I heard THAT before :P

Much more available than hypophosphite salts.

I imagine that the harsh conditions of a HI/RP trash the yields too in the krokodil syntheses. I see it easily opening up the epoxy bridge. Can anybody post an actual krokodil 'tek' ? not because I want to do it obviously, I'm quite attached to my wings and would like to stay that way, but I'd like to know what they are actually doing.
« Last Edit: April 04, 2012, 02:34:15 AM by Tsathoggua »
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Assyl Fartrate

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Re: Permonid Synthesis from Codeine
« Reply #21 on: April 04, 2012, 06:13:05 AM »
It seems probable that they would get mostly junk, stuff with the epoxy bridge broken, rearrangement products, etc., along with some 7,8-dehydrodesomorphine and desomorphine. HI should reduce the allylic alcohol, right? And it will surely cleave the 3-MeO phenolic ether. Then there's all of the leftover phosphorus and iodine... truly a disgusting and (for someone with their resources) unresolvable mixture.

http://127.0.0.1/talk/index.php/topic,2959.msg30257.html#msg30257

Check that out... forgot to mention it in this thread. The Birch will reduce allylic alcohols quickly and reasonably cleanly, surely much more so than RP/I. It would not cleave the 3-MeO which is actually advantageous as it would allow an A/B to be done after the rxn to clean it up. It seems improbable that 7,8-dehydrodesocodeine would differ much in potency from desocodeine itself. Yields would probably be a lot higher than RP/I so even though 3-MeO ethers tend to be 10x less potent, the yields very well may make up for it. Besides, these compounds have the advantage of high oral bioavailability, offering options to those who don't want to mess with needles.

Maybe shake and bake opiates will become a reality after all. Would suck for the folks in the states though - codeine's OTC almost everywhere else in the world.
« Last Edit: April 04, 2012, 06:17:15 AM by Assyl Fartrate »
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hyjroul

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Re: Permonid Synthesis from Codeine
« Reply #22 on: January 28, 2013, 06:27:05 PM »
Very interested in the desocodeine, anyone knows it's bioavailability when smoked, in fact, it can be smoked??

What's its potency compared to morphine?

I'm definetly in for this an as soon as I have some basic information in the Desocodeine or the 7,8-Dehydrodesocodeine in terms of potency and that and will try it  and post results and bioassay , because I have basic experience with Birch's and I think I can do it.

By the way i can't see this document you linked Assyl Fartrate: http://127.0.0.1/talk/index.php/topic,2959.msg30257.html#msg30257

Regards!! :)
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