Author Topic: Muira Puama  (Read 47 times)

salat

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Muira Puama
« on: May 08, 2010, 05:52:53 PM »
Muira Puama (Ptychopetalum olacoides) bark is an aphrodesiac from a tree in South America.  

Caveat:  I am still very much a beginner in chemistry - I tend to absorb a lot of information when I'm researching - digging up a trail only to lose the path that got me there.  I'm also horrible at remembering the specific terms - please do your own research on any recipe I give or ask me to doublecheck on anything that sounds fishy.

I've been working on getting all my equipment setup etc and learning how to do distillation, vacuum filtering etc.  I'm interested in broad range herbalism - prefer it to traditional medicine and my emphasis is on stuff that makes you feel good and keeps you healthy.  

So if there's an interest, I'd enjoy sharing and discussing the research I'm doing both practical and theoretical on various herbs which may be of use to readers of this forum.  

Here's a writeup on Muira Puama - (keep in mind these guys are trying to sell something)
http://www.rain-tree.com/muira-puama-extract.htm

It's also available from Mountain Rose for $6 a pound cut/sifted bark - I prefer cut/sifted because it gives you more options for extraction.
http://www.mountainroseherbs.com/bulkherb/m.html

(I'm not selling anything, but I see this stuff listed on shaman shops for 4$ an oz and that's highway robbery!)

It potentially has dopaminic effects, some research I have read suggested that it actually causes release as well as reuptake inhibition.  There is a supplement called catuama that is a combination of muira puama and catuaba that is reputed to have anxiolytic and aphrodesic effects.

http://www.ncbi.nlm.nih.gov/pubmed/19067380
http://www.ncbi.nlm.nih.gov/pubmed/19815648

I've uploaded two pdfs - a patent and a research paper.  

My experience with the plant is limited so far - I have brewed several teas using neutral grain vodka (40% EtOH) mixing it with catuaba and ascorbic acid.   I found out brewing the two together seems to have a better effect, but is subjective and time will tell.  Since I didn't have my lab setup, I experimented by simmering them together in vodka for about 20 minutes and leaving it sit over night then filtering.  Then I evaporated the alcohol one serving at a time.  Take it with about a gram of arginine - this enhances the effect.  I don't know if the ascorbic acid is needed for the extraction - I read it enhances the drug somehow in a patent.  Last time I made it I put it in the mix at brew time, that brew seemed to have a bigger punch.

Effects -  The catuaba part seems to have the effect of moving the blood circulation to the peripherials - skin becomes more sensitive to touch, chills, flushing effects, tingles up the neck and spine - goes nice with sex!  I believe the Muira Puama part does increase dopamine - mood mellows, anxiety is less, sexual desire increases.

Side Effects - your heart can have a sort of speed up when the blood starts moving out, I read up on it and apparently it is harmless and your heart is actually getting an easier load (sorry I lost that reference)  I haven't found any writeups of any serious side effects - they put this stuff in drinks in South America.

Extraction Notes:
I've been researching various extraction techniques - all indicators are not to heat it too much or over process Muira Puama.  The bark is tough as nails so if you don't have mill, order the powder.  (I'm still working on my mill .. - nice inspiration from the one in the library)

It doesn't extract well unless you powder it - I tried freezing and wetting & freezing and neither of those softened it up.

I found a write up in an old pharmaceutical journal on extraction and they gave a nice recipe for percolation.  (If anyone is interested I'll try to find it)  So last night I setup a percolation using vodka.  I've been interested in that technique for a while because sometimes too much heat and processing can destroy elements of a plant that are synergistic.

This book http://books.google.com/books?id=J_LZhWKeHj4C&lpg=PP1&pg=PA158#v=onepage&q=percolation&f=false has a really good writeup on percolation and how to pack a column - I plan on making one of the bottle percolation setups they describe as soon as I find my glass cutters.   (the book is not downloadable but most of the stuff about percolation is readable.)  I attached a picture of the percolation - I got a really beautiful reddish clear liquid from the vodka (might have been higher content - sometimes my vodka and everclear get mixed).    After it was exhausted I ran hot water through the percolator and got a cloudy liquid that is separating - might be saponins.  

Salat

If there's a help page on how to format these posts could you point me to it - I work with computers all day long and don't have a lot of patience with it in my spare time...
« Last Edit: May 08, 2010, 06:15:14 PM by salat »
Salat

salat

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Re: Muira Puama
« Reply #1 on: May 08, 2010, 11:46:36 PM »
Pharmacy of Muira Puama:  
 This drug stands in high repute in Brazil  as an aphrodisiac Cassar and Loretz recommend the following pharmaceutical preparations for use.  Fluid Extract of Muira puama Muira puama wood in coarse powder 100; alcohol 90 percent 20; glycerin, 10; are mixed and allowed to macerate for two hours and then percolated with dilute spirit to complete exhaustion about 400 500 parts of dilute alcohol are required Dose 2 to 3 Gm twice or three times daily.  To prepare wine of muira puama (1-10) take of muira puama wood 100 alcohol (90 per cent) 25, distilled water 25, sherry 950, Macerate for ten days press and filter Dose 20 to 30 Gm twice or thrice daily The fluid extract is the best form for use Pharm Cent 40 611

Pharmaceutical journal, vol 63 Pharmaceutical Society of Great Britain
http://books.google.com/books?id=vVcCAAAAYAAJ&dq=Muira%20Puama&lr&as_brr=1&pg=PA601#v=onepage&q=Muira%20Puama&f=false
« Last Edit: May 08, 2010, 11:48:29 PM by salat »
Salat

Vesp

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Re: Muira Puama
« Reply #2 on: May 09, 2010, 12:25:51 AM »
That is an interesting plant. What are the main compounds that are thought to be responsible for it? I looked around at some of the links and it only seems like some terpenes/teperenoids or something like that, but besides that do you know the name of the active compound?

That is a rather interesting little glass thing you've got there, I like it and how it has been put to use. What was it originally or what did it come from?
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salat

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Re: Muira Puama
« Reply #3 on: May 09, 2010, 05:03:39 PM »
I don't know what the glassware is - I got it on ebay because it looked a little like the percolators shown in the old pharmacy journal.  My husband who is an experienced amateur chemist says that he thought they were used in chromatography for solvent dispensing.  A rubber tube inserted into the bottom to drip the solvent into the chromatography column.   I am looking around for a better mechanism for hanging and dispensing - those two currant jam jars were the only thing that fit and I don't want solvent evaporating.

I want to try out the design in the book link I posted - just don't happen to have a ronco bottle cutter!!  What was interesting about that design was that a glass water bottle with metal cap is inserted into a mason jar and the metal cap loosened to allow control of the rate of solvent drip.  

The description of packing was well worth reading by anyone who's trying to do a soxhlet - I've been trying to get that right for a while - trying combinations like diatomaceous earth or ceramic tubes.  Think my husband is right (again damn him!  :P) that the pack needs to be elevated about an inch or so above the outlet so gravity does it's job.  

I tried two packs for the percolation and the one I did the tightest gave the strongest extract the fastest - whole thing was done in a couple hours.  I'm doing b caapi now - did one with just 96% EtOH and another with acidic water.  

Regarding Muira Puama and active ingredients - it has only recently begun to be studied.  I have a book from the early 80's on pharmacognosy that completely discounted it and a number of other plants that are now being shown to have some very valid effects.  Duke's was REAL helpful - he just says "ALKALOIDS". Others refer to a mysterious resin - which makes me wonder if I need to be attempting to extract that - which would call for heat right?  The write up on raintree mentions long chain fatty acids - which interests me because the leaf contains Arachidic acid  http://en.wikipedia.org/wiki/Arachidic_acid acid follow that to -> http://en.wikipedia.org/wiki/Arachidonic_acid and then follow that to -> http://en.wikipedia.org/wiki/Anandamide.  So there could be something there in the root.    AThe writeup on raintree does list the chemicals present so perhaps you'll see something of interest.  

The traditional uses is for people feeling lethargic and lacking motivation.  It is also promoted as a nerve tonic/protective - which if the active is a long chain fatty acid would make sense - DHA and other long chain fatty acids are great for the brain.

salat
Salat