Aldol Method

bio · Working Bee

This caught my eye in the Baeyer/Villiger thread as a possible improvement to gassing at 0deg for hours. I sure wish somebody could correct the spelling in the title of that thread, it just bugs me. Laughing

Yield: 85 percent
Reagent: H2SO4, AcOH
Time: 20 hour(s)
Other Conditions: Ambient temperature

Ref: Kawai, Yasushi; Saitou, Kentarou; Hida, Kouichi; Dao, Duc Hai; Ohno, [Atsuyoshi;
Bull. Chem. Soc. Jpn.; EN; 69; 9; 1996; 2633-2638.

Reagent: H2SO4, AcOH

Ref: Kawai, Yasushi; Saitou, Kentarou; Hida, Kouichi; Ohno, Atsuyoshi; Tetrahedron: Asymmetry; EN; 6; 9; 1995; 2143-2144.

I suppose I should run a couple test tube experiments. My quess is the AcOH is used as solvent and the H2SO4 I would try at 1,2.5 & 5% total weight with the GAA at equal volume to the benzaldehyde. Damn should do it tonight as my flea magnets just came in. Cool little suckers they fit a big test tube just perfect. and will spin a foot away.