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Forseti
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| Joined: 05 Jul 2005 |
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35.54 Points
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searchinī for L(-)ephedrine suppliers
Wed Jul 06, 2005 1:43 am |
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Hi, everybody!
I need some help! However, the chemistry is not my problem. But I donīt wanna extract ephedrine from pills... |
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loki
guinea pig
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| Joined: 09 Mar 2005 |
| Posts: 391 |
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14167.88 Points
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re: searchinī for L(-)ephedrine suppliers
Wed Jul 06, 2005 3:07 am |
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| good luck with getting them to send it to ya. there's two big producing countries, china and india, india has cracked down on diversion significantly... i dunno anything about what's involved, but i'd say for a start that you won't get less than kilo batches at a go. swim'd be interested in hearing about it however, but at the same time swim thinks he would prefer to just get into growing plants and perfecting the extraction and isolation. |
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Bander
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| Joined: 01 Mar 2005 |
| Posts: 2 |
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33.82 Points
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re: searchinī for L(-)ephedrine suppliers
Wed Jul 06, 2005 10:46 am |
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There's a interesting discussion going on over at ScienceMadness dealing with the production of L(-)ephedrine with slightly altered yeasts.
| Organikum wrote: |
hydroxyphenylacetone - a biosynthesis
Theoretic part I
Patent: DD51651
Method for the production of l-ephedrine
Prior art:
- Use of an acid resistant yeast. A aerated suspension of bakers yeast is exposed over 40 minutes to rising concentrations of 0,3% to 10% of a mixture of sulfuric and phosphoric acid in water. Then this yeast is allowed to ripen in a solution containing molasses. The yeast is separated and used as inoculate in the production of l-PAC.
- Use of simple bakers yeast and molasses with or without the addition of the usual nutrient salts. The addition of hydrogen acceptors is supposed to reduce byproducts. 31% to 35% yield.
hydrogen acceptors are for example acetaldehyde, the addition of nutrient salts is told to LOWER yields!
- A nutrient solution containing 3,5% unrefined sugar, 6% molasses, 0,05% MgSO4.7H2O with a ph of 5,5 is used. Acetaldehyde (50% in water) is used as hydrogen acceptor in a ratio of 1 to 1 to benzaldehyde. Bakers yeast (saccharomycesis cerevesiae) is used in the fermentation. Benzal and acetaldehydew are added in four portions of 0,2% of the volume of the fermentation broth over a time of 7 to 8 hours. Between the 3rd and 4th addition about 20% to 25% of the starting amount of yeast are added. Yields are reported with 55% on benzaldehyde.
......
The description of the invention is identical to the examples given so I spare this and provide the examples:
1. 800g cane sugar molasses (50% saccharose), 5g potassiumdihydrogenphosphate, 2,5g MgSO4.7H2O epsom salt, 16g ammoniumsulfate, 4liters water.
This is adjusted to a ph of 4,7-5,2 with 50% phosphoric acid. 164g yeast are subjected to fermenattion for 30 to 45 minutes then 32g benzaldehyde and 48ml acetaldehyde (50% in water) are added in four portions every 60 minutes. After 4 to 6 hours 20g l-PAC have formed. The yeast is separated, the liquid is extracted with 3 to 4 equal portions of ether or DCM. The raw extract can be used as is for the reductive alkylation to l-ephedrine.
Isolation of the pure l-PAC so wanted: The raw extract in ether is shaken with sodiumbicarbonate solution (10%) which removes the byproducts mostly the carbinolo is then extracted by the bisulfite additionproduct, followed by neutralisation in water, extraction with ether again and distillation at 120°C to 125°C at 12mm/Hg.
44% yield on benzaldehyde.
2. Nutrients like in 1. 40mg thiamine are added, 5 to 7 hours 24,5g l-PAC, 55,5% yield.
3. As in 1. plus 5% corn steep liquor, 6 to 8 hours, 55,5% yield.
4. Instead of corn steep liquor, 10% whey is used. 6 to 7 hours. 62,5% yield.
5. Like in 1., but instead of 800g only 320g cane sugar molasses is used and 1600g brewers wort (17% to 18%sugar) is added. 8 to 10 hours, 34g l-PAC, 76,5% yield.
Whey, cornsteep liquor and brewers wort contain thiamine and obviously other enzymes favorable in the biosynthesis. The use of acid-hardened yeast as described in the prior art is told to have similar good yields.
Hydroxyphenylacetone = PAC
A beautiful biosynthesis, dicovered 1921 by Neuberg/Hirsch and nowadays one of the most successful biosynthesises in the world.
And no, I am not interested in making ephedrine, my heart beats for oxazilones....
Part two with some remarks of mine on the theory and praxis of this synthesis and the necessary setup are to follow. And maybe a practical part lateron.
This thread is intended to show a biosynthesis which is easily to reproduce by the interested amateur experimenter, it is on the process, the problems of such processes and how to solve them.
I will ask chemoleo to delete every post which intends to drive this thread into a direction aiming on possible endproducts.
ORG
[Edited on 30-4-2004 by Organikum]
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amenselah
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| Joined: 31 Mar 2005 |
| Posts: 38 |
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1199.62 Points
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re: searchinī for L(-)ephedrine suppliers
Mon Aug 01, 2005 10:56 pm |
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| Uncle Fester has also a recipe from growing ur own eph. using brewers yeast.. |
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java
Consumer
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| Joined: 07 Feb 2005 |
| Posts: 736 |
| Location: The Mexican Republic |
21794.14 Points
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re: searchinī for L(-)ephedrine suppliers
Mon Aug 01, 2005 11:02 pm |
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| That's the biotransformation of the yeast and benzaldehyde that Bander has alluded to and there are many threads on the subject " L-PAC Biotransformation".........it would serve you well to stock up on the subject and read it so you know what Fester meant when he says growing your ephedrine......java |
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