N-phenethyl-3-methyl-4-piperidone

nobodyimportant · Fri Jul 08, 2005 3:05 am

oops, be afraid

stratosphere · Fri Jul 08, 2005 10:21 am

from 4-piperidone you would have to add your N-phenethyl group, alpha halogenate, protect your carboynl by forming a acetal, then react with methylmagnesiumchloride.

im not even sure if you can form an acetal with a alpha halogen but youd have to protect the carboynl somehow before reacting with the grignard.

Ephoton · Fri Jul 08, 2005 7:00 pm

hmm look up drone he was the dude for this shit.
I could never get to fent with out buying serious chems or doing way
to many steps(logical fent never made becouse of this). but drone made an anologue using the oil of a nightshade
for the piperidone substitute

nobodyimportant · Fri Jul 08, 2005 9:08 pm

oops, be afraid

stratosphere · Fri Jul 08, 2005 9:23 pm

where are trying to put the methyl group?
cuz 3-methyl implies a methyl group on piperidone ring, and it sounds more like your interested in alpha-methyl fentanyl.
in which case you could use the many methods available to produce p2p (the amphetamine precursor) and reductivly aminate the piperidone with that, although the carbonyl on the piperidone would have to be protected first to avoid manufacturing polypiperidine.

nobodyimportant · Fri Jul 08, 2005 9:28 pm

oops, be afraid

Ephoton · Sat Jul 09, 2005 7:09 am

im not sure this one is safe if your not in the know on strong opiods.
one fuckup and everyone in house is dead on an od really strong stuff.
could be wrong and you might be an awsome chemist but if you do try it be carefull
if your dead set on it ill find the refs on piperidinone synth just please be carefull
when you get near the end of the synth if you let any into the atmosphere
you had better be ready with the narcaine then get everyone the fuck out of there
dangerous realy dangerous

stratosphere · Sat Jul 09, 2005 7:47 am

about the only possible way i see to get 3methyl from piperidone is the way i put above with the 3-chloro piperidone reaction with methyl magnesium, not very easy chemistry.
what makes you think 3 methyl analog is worth experimenting with?, if you already have access to piperidone why not just go with regular fentanyl.

also if you don't know alot about chemistry id say wait till you do before worrying about novel compounds. i mean most people here arn't thrilled about holding someones hand who is totally unknowlegable and wasting their time trying to walk them through things they have no clue about and don't understand.

nobodyimportant · Sat Jul 09, 2005 11:28 am

No, I'm not even gonna make regular fentanyl. I just need to find out whether it is possible to make n-phenethyl-3-methyl-4-piperidone with 4-piperidone. Anyway, thx for bearing with me.

Ephoton, I'd really appreciate any refs on the synth. Thanks.

Stratosphere, I don't think I have asked for "hand holding" type help. However, thanks for the idea regarding 3-chloro piperidone with methyl magnesium.

Stinging_Nettle · Sat Jul 09, 2005 1:46 pm

J.Serb.Chem.Soc. 69(7) 511-526 (2004)

stratosphere · Sat Jul 09, 2005 8:29 pm

ok, but id at least recommend making the effort to understand the structural difference between this and regualr fentanyl if your interested enough to want to learn how make it.

ill admit im by far not the worlds premiere expert on opiate agonists, whats the motivation for wanting the 3-methyl compound so bad?

stooge · Sun Jul 10, 2005 2:43 am

hm, swis'd like to know how, too - in his eyes 3mfentanyl is better than normal fentanyl as it's more potent and has a longer acting time. when using opiates regularly it can become pretty annoying to get a dose every one or two hours Smile

at least this would be swis's motivation to rather go for something like 3-methyl-fentanyl than simple fentanyl, don't know about other people

nobodyimportant · Sun Jul 10, 2005 9:21 pm

Stinging Nettle, got it, thx.

The synthesis and preliminary pharmacological evaluation of the racemic cis and trans 3-alkylfentanyl analogues
M. D. Ivanovic, I. V. Micovic, S. Vuckovic, M. Prostran, Z. Todovic, V. D. Kiricojevic, J. B. Djordjevic and LJ. Dosen-Micovic

Stratosphere, I can draw it for you in ascii art, but it looks horrendous.

"whats the motivation for wanting the 3-methyl compound so bad?"
My old enemy, curiosity.

nobodyimportant · Mon Jul 11, 2005 4:17 am

oops, be afraid

piglet · Thu Sep 29, 2005 5:40 pm

If your working with opiates, simply order naltrexone off the net & dose yourself on about 50mg per day. Voila, your protected!