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synthetic cocaine (from citalopram)
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opa

Joined: 03 Aug 2005
Posts: 8
264.14 Points
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synthetic cocaine (from citalopram)

 Sat Aug 27, 2005 9:27 pm		 Reply with quote
hi
i've thought of a way to produce a cocain-like dopamine uptake inhibitor from the antidepressant citalopram.
the hydrophilic cyano-substituent of citalopram isn't able to interact with the lipophilic phenylalanin-site within the dopamine-transporter, so the whole molecule remains inactive here.
so how could this cyano be removed or alternately be replaced by a halogen in order to get a hydrophobic moiety and allow it to play with the dopamine-transporter, any ideas?

Molecular Mechanism of Citalopram and Cocaine Interactions with Neurotransmitter Transporters:
http://jpet.aspetjournals.org/cgi/content/full/307/1/34
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omar148

Joined: 13 Sep 2005
Posts: 2
51.90 Points
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re: synthetic cocaine (from citalopram)

 Thu Sep 15, 2005 2:31 pm		 Reply with quote
hi everybody
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