Benzofuran analogue of MDMA

MobiusDick · Sat Sep 03, 2005 1:04 pm

I don't have the references regarding the behavioral pharmacology of the the benzofuran analogues of MDMA at hand, but they are selected by primates trained on MDMA without discrimination between the two. (i.e., moving the ) around on the 3,4 methylenedeoxy ring

Does anyone have ideas how this might be synthesized by any methods? How about the best grignard reaction for this assuming precursors were available (not that they are, but assume they are.)

MobiusDick

MobiusDick · Sat Sep 03, 2005 1:08 pm

Here is a reference, but I have some really interesting ones at school.

http://www.erowid.org/chemicals/iap/iap_info2.pdf

MD

MobiusDick · Sat Sep 03, 2005 1:24 pm

By the way, an MAO-B inhibitor like Selegiline appears to prevent the neurotoxic effects of these types of compounds due to inability of MAO-B to convert dopamine to DOPAC (dihydroxyphenylacetic acid ), which causes the oxidative cellular injury leading to neurotoxicity. Methamphetami1ne also gets its neurotoxicity from this method. This then allows the enzyme COMT to 3-OMD (3-O-methyldopa ) Homovanillic acid (HVA or HOVAC) may also be involved in neurotoxicity, but this is also an MAO ancillary pathway.

MD

MobiusDick · Sat Sep 03, 2005 2:02 pm

The article just answered my question. Thanks anyway!

MD