First LSD Synth Post-Bright Star Bright Star

java · Consumer

Bright Star
( )
04-12-00 02:07
No 127065

Re: First LSD Synth Post

And ...

This is NOT the FIRST LSD thread ...
There have litterally been hundreds ... and such arguments that this board hasn't seen since ....

Nocturnal
(Member)
04-12-00 02:54
No 127066

Re: First LSD Synth Post

Very good links bright star. Much appreciated. I ment that this was the first LSD synth post in the new tryptamine forum. Nocturnal just wants to familiarize himself with different L synths in hopes of one day dreaming of producing LSD. Dreaming of your wacker synth was fairly easy since there are alot of bees who dream about X here at the Hive. I could get answers to all the questions that I had and I could post my problems and bees would have solutions for them. But as I see now, it is different with LSD, I do not have nearly the skill nor formal chemistry training needed to complete this synth, and there are not many bees who dream of LSD so I wouldn't be able to get much help along the way.

Nocturnal
(Member)
04-12-00 08:48
No 127063

Re:First LSD Synth Post

There are several L synths on this page. Which would be the best? Why?
http://www.totse.com/files/FA049/make.htm

Bright Star
( )
04-12-00 11:43
No 127064

Re:First LSD Synth Post

That is the old method.   Very challenging and not good yields. This one is better, and the PURE precursor can be had in some of the third world countries ...

IMHO .. The best one:
http://www.drgrim.com/taoid/lsd_synthesis.txt

Second Best ... Shulgin's Method:
http://www.lycaeum.org/books/tihkal/

The old ones:
http://rhodium.lycaeum.org/chemistry/lsd.synth.txt
http://rhodium.lycaeum.org/chemistry/lysergic.amides.txt

Some Grand Ref's:
http://rhodium.lycaeum.org/chemistry/lsdsyn.txt

Note:
This synthesis is very tough. It would stretch the nerves and skill of a TALENTED organic chemist.   Especially the old synths ...
It is kind of the Holy Grail of synthesis. If you cannot dream of ----, X, 2C-B ... or ANY of the trypamines.   Then forget it.   You'll never get the required yields for the next synth.

If you can't calculate moles. Then go back to school.   This is not a 'complete idiots guide'. There isn't one.   This is synth ... think ... extract ... think ... react ... think ...

Go big or go home.

painiac
(Member)
04-13-00 00:07
No 127067

Re:First LSD Synth Post

Once upon a time I heard someone say something about a one pot shot for "LSD"
(unrealistic i think looking at the multiple lighting thing in brightstars favorite).. someone also said it was uncle fester's synth.. anyone know?
ps. brightstar.. that is an awesome mdma write up.. i can just see it..

zephler
(Member)
04-13-00 20:26
No 127068

Re: First LSD Synth Post


The one pot shot is festers rehash of a now 50 year old method. There is no one "pot shot".   Although the skill to perform the feat is high, so too is MDMA manufacture. I don;t recommend anyone try them. But POCl3 is commonly available for the dehydration of alcohols, isn;t it?

zephler
(Member)
04-13-00 20:27
No 127069

Re: First LSD Synth Post

I wonder too, if the POCl3 is in pyridine, the form used for E2 reactions with alcohols

painiac
(Member)
04-13-00 22:27
No 127070

Re: First LSD Synth Post

shit.. after reading brightstar's writeup i think anyone with a good concept of chemistry could do it if they study it and can operate the equipment. i think one part of being a good chemist is to be able to think metaphysically.. you know, see the electron excanges and the like from an atomic view. ---- takes a little; mdma, proficient; and LSD takes excelent understanding. i hope to understand like that one day, but till then i'm on the simple reduction/ acid base extraction level. it takes someone like brightstar and other pimps to put it to us in general terms so that we may one day get there. i am so glad that i can be here to learn (cause i thin its gonna get darker before it gets lighter in the world of drug info on the net).. i hope we can one day talk shit about acid like the biggest problem is getting enough LSA to run the synth.

Bright Star
( )
04-14-00 02:42
No 127071

Re: First LSD Synth Post


Its actually harder than you think.

POCl3 is watched. Why?   It is THE precursor for Sarin Nerve Gas.   Fucking destructive radicals, make it so hard for us peace&love types.

The one Pot shot is a myth.

Dream smaller dreams first.

Roll over, crawl, stand, walk, run ... olympic team?

IronMonkey
(Member)
04-14-00 02:57
No 127072
Re: First LSD Synth Post

You don't need much POCl3, and if you already have a proper system for acquiring items you should be able to get what you need for several ounce batches.

Bright Star
( )
04-14-00 16:32
No 127073


Re First LSD Synth Post

Very true.   10mL should last a very long time.   That and 10mL of DiEtAmine should last about as long ....

tube
(Member)
04-18-00 06:04
No 127074

Re: First LSD Synth Post

According to Johnson et al. "All steps were carried out with considerable experimental ease".

Johnson FN, Ary IE, Teiger DG, Kassel RJ.
Emetic activity of reduced lysergamides.
J Med Chem. 1973 May;16(5):532-7

formula54
(Hive Bee)
11-28-01 15:56
No 241746

Re: First LSD Synth Post

i regard to bright star's first link...does any bee remember what synthesis this might have been?
(the link is dead)

"If I were a "lady" I wouldn't be telling anybody here."
-tamerlane

formula54
(Hive Addict)
12-02-01 00:34
No 243188

Re: First LSD Synth Post

good lord this forum is dead

-swis54

scarmani
(Hive Bee / Eraser)
12-06-01 16:59
No 245092

Re: First LSD Synth Post

Sorry for the off-topic post; (and the software glitch is probably temporary)

but the thread-link in the forum goes to the third post in this thread.

Those innocent eyes slit my soul up like a razor.

halfapint
(Ubiquitous Precursor Medal Winner)
12-25-01 07:59
No 250385

Re: First LSD Synth Post

responding to the TOTSE site LSD synth question

There are three LSD synths there. (These, and more, are at Rhodium's.) The first is Hofmann's original method, hydrazide to azide, which yields a racemate which then has to bee rectified, not fun, low yields. The second uses unobtainable reagents and unrealistic conditions. If you got any trifluoroacetic anhydride on you, grab a quick shower. The third is the shits, Garbrecht's synthesis, high yields, fast and easy.

The problem is that the procedure given does not contain enough information to successfully carry it out. Nor does the Garbrecht synthesis on Rhodium's page. Both lack the crucial information that the synthesis is extremely sensitive to the exact equivalents of SO3 to lysergic acid. You must have precisely 3 equivalents, or you're spinning your wheels; yield falls to near nothing, if your measurement is off the slightest bit.

Copper (II) sulfate will give SO3 at a lower temperature than iron (II) sulfate.

Edit: Arrgh! Can't believe I got caught up in a software glitch like this! Natch, I didn't even look at the date on the post. Thought something looked familiar. Did wonder why what I posted didn't show up, wondered briefly if tryptamine chem had been made moderated like serious chem, curious enough to look again, now I just can't get my feet out of this tar pit.

Rhodium
(Chief Bee)
12-25-01 13:59
No 250410

Re: First LSD Synth Post

Halfapint: Could you reference this need for the exact measurement?

halfapint
(Ubiquitous Precursor Medal Winner)
12-25-01 19:51
No 250463

Re: First LSD Synth Post


Its requirement for the exact stoichiometry is emphasized in Garbrecht's original paper, in J Org Chem. I can't even remember the year he published, I think 1967. (This is why I have jabbed at your brief overview text from time to time, hoping somebody would post that part of his paper.) Some unscrupulous ruffians stole my entire chem library, and presented me with other insults. That wasn't lately, but I have had to rely a lot on memory since. Not the best thing to rely on.

Garbrecht reviewed the 4 or 5 preceding syntheses for lysergates, with their conditions and their yields, making a convincing case that his sulfur trioxide/DMF complex method was the best up until that time, but only if exact equivalents were used. (His explanation ran something like one for the lithium salt, another hangs around the indole nitrogen, and the third complexes with the carboxyl, or a similar confusion.) Now I have no doubt the POCl3 route may bee as good, or that using the more contemporary coupling agents with the cryptic acronyms might give better results. Yet this way is good enough, call it a sentimental favorite.
turning science fact into <<science fiction>>

bujinkan
(Hive Bee)
12-28-01 09:30
No 250954

Re: First LSD Synth Post

interesting post halfapint, thanks.

(sentimental favorite?!? haha)

UTFSE
(Hive Bee)
01-06-02 15:43
No 253317

Re: First LSD Synth Post

eight pages of hits on "Garbrecht" on patents.(inventor)
lots with ergo---- or lyser------ in dem.
even more with "No title available"!!
just glad to bee here-----he he he

rommstein2000
(Stranger)
01-09-02 12:29
No 254441

Re: First LSD Synth Post

goto Rhodium (http://rhodium.ws), almost all the info at TOTSE was taken from there or from erowid/lycaeum. peace[/u

halfapint
(Ubiquitous Precursor Medal Winner)
01-09-02 18:12
No 254547

Re: First LSD Synth Post

Caught another one! This bug was beehaving exactly like it was over Chrissmiss! (And probably the last of November.) It was showing only the third post, and dragging the thread up to or near the top of this forum. The Twilight Zone is closer than you know. The fabric of reality is stretched very thin, in and around the Hive...

SOMEBODY LOCK THIS THREAD PLZ...
turning science fact into <<science fiction>>