Best route to 5meo-Dipt is?

java · Consumer

Hierophant
(Stranger)
05-19-00 22:44
No 6882
      Best route to 5meo-Dipt is? Bookmark

I posted to this forum before with this question (before the new board), and did not receive a satisfactory reply before the switchover. Is Shulgin's synthesis the best route to 5meo-Dipt (in terms of chemical availability and yield)? If not, then what would be a better route? The starting material is 5meo-T. Any ideas?

Rhodium
(Chief Bee)
05-25-00 06:48
No 9170
      Re: Best route to 5meo-Dipt is? Bookmark

Another good way is to use the method for DIPT (--4 in Tihkal), but using 5-methoxyindole instead of regular indole in the process. The procedure wouldn't be much different.
http://rhodium.lycaeum.org

kokopelli
(Stranger)
05-29-00 05:39
No 10689
      Re: Best route to 5meo-Dipt is? Bookmark

how about using 5-meo-Tryptamine (made from Melatonin),
sodium cyanoborohydride and isopropylbromide in a solution of methanol ????
koko

psyloxy
(Hive Bee)
05-29-00 08:36
No 10733
      Re: Best route to 5meo-Dipt is? Bookmark

wouldn't that be acetone instead of iPrBr ?
Rhodium has a nice text in his archive that details exactly this kind of rxn.
--psyloxy--

CHEM_GUY
(Hive Bee)
06-04-00 14:23
No 13679
      Re: Best route to 5meo-Dipt is? Bookmark

They will calll you and try to see if you are a legitamate researcher. Only deleivered to business adresses as well.
This post is for informational purposes only an is not intended to facilitate illegal activity.

Hierophant
(Stranger)
06-04-00 22:50
No 13809
      Re: Best route to 5meo-Dipt is? Bookmark

Would buy, except that I find it rather expensive (compared to preparing it from scratch). With Shulgin's method --37, it works out to about $400 for 12-14g (with enough chemicals left over to do it again, after puchasing more 5-Meo-Tryptamine. So so far this is the best method? I would like to avoid the high-boiling solvents of --37 (hexane and sulfolane), and I dislike working with LAH al la --4. Any ideas people?

psyloxy
(Hive Bee)
06-05-00 09:06
No 13960
      Re: Best route to 5meo-Dipt is? Bookmark

Buy 5-MeO-Tryptophol, then it's only 2 steps [1:PBr3 or PI3][2:diPrNH] to foxy.
--psyloxy--

Evil_Nefarious
(Stranger)
06-06-00 12:25
No 14478
      Re: Best route to 5meo-Dipt is? Bookmark

Re --37, what other solvents can be used?
Re 5-MeO-Tryptophol & 5-Meo-Tryptamine, just how watched are they?

Evil_Nefarious
(Stranger)
06-06-00 13:21
No 14493
      Re: Best route to 5meo-Dipt is? Bookmark

I haven't checked exhaustively, barely even at all yet. I would take that task on with a much happier air if you would expound upon your two step process above.
Mr. N

psyloxy
(Hive Bee)
06-06-00 22:08
No 14698
      Re: Best route to 5meo-Dipt is? Bookmark

Phaidon: I checked chemfinder and some companys have it. There's also 7-OH and 6-MeO tryptophols and such... But not 4-OH-trytophol, sadly. Don't know what prices would be like but I think it is worth it since the 5-MeO's are that much more potent.
--psyloxy--

psyloxy
(Hive Bee)
06-07-00 11:37
No 14967
      Re: Best route to 5meo-Dipt is? Bookmark

Evil: http://rhodium.lycaeum.org/chemistry/tryptophol.txt
--psyloxy--

Brivator
(Stranger)
06-07-00 22:13
No 15205
      Re: Best route to 5meo-Dipt is? Bookmark

Hi boys
With regard to the 1969 tryptaphol to tryptamine reaction: isn't it a bit old-fashioned? What about Mr. Mitsunobu?
With regard to Rhodium's comment that other forms of Ni can be substituted: I recall from my pre-stripper days trying just such a reaction using Ra-Ni. I'm pretty sure I got the reference for this from Larock.
With regard to converting to the bromide and then displacing with a secondary amine: the second step might require a sealed tube (again, vague recollections from Larock).
When I get the shakes, I wiggle.