What is the problem with this tryptophan?

java · Consumer

apis
(Stranger)
05-31-00 18:27
No 12040
      what is the problem with this tryptophan? Bookmark

Let's say that a man and his horse were attempting a decarboxylation of tryptaphan (20g ground from prescription tablets minus papery coating) in xylene (200ml) with diisobutylketone as a catalyst(5g) and this mess had been percolating at reflux for the last 12 hrs and the only change that was apparent to the scantally clad eye was that the formerly white undissolved and undissolving powder was now a less radiant shade of beige, what would you tend to see as being the likely source of this lethargy?

apis
(Stranger)
06-02-00 12:40
No 12922
      Re: what is the problem with this tryptophan? Bookmark

Man and horse are now coming up on 60hrs. with little action. The horse is sad. The man is sad. Could some impurity (magnesium stearate, cellulose, some whitener, or binder) be eating up the cattle-ist? could the boiling boint of xylene be too low at their foothills E. of Rockies locale? Someone say something or at least send some oats for the horse.

Vulpes
(Stranger)
06-04-00 23:16
No 13819
      Re: what is the problem with this tryptophan? Bookmark

Sorry I dont read this enough any more. It looked like xylene would boil too low. I never tried it though (not that I would anyway Wink

dont use DMSO either... try to get cyclohexanol (i think thats it) its the only one that I have read confirmed reports for...all others are problematic or not working at all... what method does your horse intend to use to make his special medicine...

Badger · Mon Feb 14, 2005 3:28 am

1) If you can't get pure tryptophan you should make it by separating it from all the other shit. It's probably dissolved in the toluene but I didn't look up its solubilities. If it is, filter out the other crap and evaporate the solvent until crystals of T form.

2) Dissolve the T in a high boiling solvent like diphenyl ether and the ketone you used was probably fine. Cylcohexanone or MIBK work.

3) watch for CO2 bubbles and heat until the bubbling stops and then another two hours.

Starting from scratch:

Get some T from a health food store and by it in capsules. Dump the contents in DCM and filter out any other shit.

Crytsallize it from the DCM and use the method above