serotonin-depletion after-effect of ----?

loki · guinea pig

I have noticed that I am quite sensitive to serotonin agonists in recent past, and also, to strong serotonin antagonists (dexamphetamine for the former, ritalin for the latter) - and this has got me thinking about the serotonin activity of methedrine. Having had the opportunity to sample high (ish) purity methedrine on a couple of occasions in the past, it seems to me that ---- has a mild serotonin antagonism that increases with dose and manifests with some time elapsed from initial administration.

The most recent concrete example: after a high-dose (possibly in the range of 75mg) ---- experience, i noticed that for two days I slept longer than usual (10 hours vs 6-7) and that upon waking after the first sleep after 30 hours awake from the dose that I craved food immediately, and for several days afterwards also slept very long and seemed to have an increased appetite for several days after.

the link between serotonin depletion and appetite increase has only recently been suggested, but from experiments I have had with this so far, it seems correct, and explains why post-tryptamine and lysergamide experiences that one has a stronger desire and greater appreciation for gustatory enjoyment... the serotonin antagonist activity of cannabis is well known by now and it too is known for increasing desire to consume food.

The reason why this interests me is because the effect is mild, as opposed to dexamphetamine and ritalin, both of which have opposite effects. Ritalin creates an immediate and strong serotonin depletion effect that goes too far and usually causes depression, or at worst, hysteria, in me, and dexamphetamine seems to put me right off my food, increase my anhedonia, and, worst of all, seems to increase towards eventually causing asthma... The novel anti-depressant drug 'tianeptine' is a 'selective serotonin reuptake accelerator' and has been positively shown to reduce asthma symptoms as well, implying a link between elevated serotonin and asthma.

On the other hand, methedrine seems to be much more beneficial for my condition, and my working hypothesis is in part based on the idea that it has a mild suppressing effect on serotonin levels that is fairly long lasting.

IndoleAmine · Dreamreader Deluxe

----, ritalin and dexedrine all mainly influence your dopamine metabolism - not your serotonin metabolism!

They aren't serontonin antagonists or agonists..

---- though causes (as a side effect) increased serotonin depletion too (just like cocaine) and is hence more addictive than plain amphetamine (it makes you feel bad very soon if you're not high, and eventually you will develop depression, paranoia and general psychosis), but (+)-phenylisopropylamine and threo-methylphenidate both work solely through activating your dopaminergic neurons, either very selective (ritalin) or more generally (dexedrine).

The serotonin effects noted with psychedelics have got nothing to do with the appetite supressing effects of ritalin, methedrine or dexamphetamine. The effects of psychedelics are caused by an up-regulation of serotonin concentration in the "5HTA2" serotonergic receptors post drug consumption, and hence drugs acting on 5HTA-receptors are researched as both antidepressants and in hope to help all those opioid addicts (increased serotonin levels help reducing craving symptoms!)...

In other words: you're addicted, ritalin doesn't gives you the high of "feling good" that ---- can provide you with, and dexedrine is just a weak subsitute for your craving. Cocaine *may* be appealing to you too...

And the effects of loss of appetite when "on speed" aren't caused by the same factors that make you hungry when tripping on either acid or THC.....

(take less!!!! You'll live longer..)

i_a