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hydrolysis of N-methylpyrrolidinone
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amenselah

Joined: 31 Mar 2005
Posts: 38
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Mon Apr 11, 2005 5:02 pm
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What the is outcome of the strong hydrolysis of N-methylpyrrolidinone??


This is what I think...
is this right???


The pyrrolidinone would be expected to have a reactivity similar to
that of an N,N-disubstituted amide. 2-pyrrolidinone is described in
Merck as having "good chemical stability" and I would guess that the
N-methyl constituent would stabilize it further. (


Reaction of 2-pyrrolidinone with base might be expected to produce
4-amino-butyric acid (or its sodium salt if NaOH used).


1-methyl-2-pyrrolidinone reacts with base to produce the sodium salt
of N-methyl-gamma-aminobutyric acid.


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IndoleAmine
Dreamreader Deluxe
Joined: 09 Feb 2005
Posts: 681
Location: Bahamas
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Tue Apr 12, 2005 7:09 am
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4-amino-butyric acid is also called GABA and is a food supplement...
(and is no fun either; you can convert it to GBL though with a toxic nitrite involving procedure, search for Chromics posts on GABA in the hive archives)

Anyone know about methyl-GABA?

i_a
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