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304. Petrenko-Kritschenko Piperidone Synthesis

P. Petrenko-Kritschenko et al., Ber. 39, 1358 (1906); 40, 2882 (1907); 41, 1692 (1908); 42, 2020, 3683 (1909).

Formation of piperidones via cyclization of two moles of aldehyde and one mole each of acetonedicarboxylic ester and ammonia or a primary amine:



R. Robinson, J. Chem. Soc. 111, 762, 876, (1917); C. Mannich, O. Hieronimus, Ber. 75, 49 (1942); H. S. Mosher, Heterocyclic Compounds 1, 659 (New York, 1950). Cf. Robinson-Schöpf Reaction.


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