4-Methoxy-PCP Synthesis Variation Questions

[xbnmx]

https://www.thevespiary.org/rhodium/Rhodium/chemistry/4-meo-pcp.html

In the above outline, the author mentions that substituting piperidine for pyrrolidine would create an end product equally as potent as 4-Methoxy-PCP without passing through the Schedule 2 substance PCC.  If such a substitution were made, what would the new intermediate product be?  What would the resulting product be?  Would any other changes need to be made to the synthesis?

[Rhodium]

https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_docs/000529854-file_s8qm.gif" title="View this image">

The intermediate would look like compound #3, and the product like the rightmost substance. The "ArMgX" is 4-Methoxy-phenylmagnesium bromide in your case, so the "Ar-" of the product would be a 4-Methoxyphenyl ring.


Ignore the (  )_x in the picture - it's irrelevant.

[xbnmx]

1. Do you believe that the author is correct in stating the end product would be equally as potent as 4-Methoxy-PCP?

2. What software did you use to render these images?

[Rhodium]

1. Do you believe that the author is correct in stating the end product would be equally as potent as 4-Methoxy-PCP?

Yes, you can read up on general structure-activity relationships here:

https://www.thevespiary.org/rhodium/Rhodium/chemistry/pcp.shulgin.html

https://www.thevespiary.org/rhodium/Rhodium/chemistry/clandestine.drug.synthesis.html#five

2. What software did you use to render these images?

Post 461238 (missing)

(Rhodium: "ISIS-Draw vs. ChemOffice", Newbee Forum)

Post 466087 (missing)

(Rhodium: "ISIS -> GIF in Photoshop", General Discourse)

[xbnmx]

First off, the author of the synthesis claims 4-Methoxy-PCP to posses a potency of about 70% of PCP's, while Table IV in the second article you listed claims it to have a potency of 10% of PCP's; a serious discrepancy.  Does anyone have enough experience to give a third opinion?  Also, after reading the text, I believe that the author of the synthesis may also have been wrong in that the piperidine substitution would not yield a product equally potent or even with the same qualitative effects.  It would be disappointing to go through all the trouble of creating such a compound only to find it has a "street use to cause a barbiturate-like sedation."  Do you agree with my interpretation?

[Rhodium]

First off, the author of the synthesis claims 4-Methoxy-PCP to posses a potency of about 70% of PCP's, while Table IV in the second article you listed claims it to have a potency of 10% of PCP's; a serious discrepancy

No, that's the wrong substituent on the wrong ring...

Table IV: PCP with a Methyl group in the 4-position of the piperidine ring.
4-meo-pcp.html: PCP with a Methoxy group in the 4-position of the benzene ring.