Solvent recycling (mainly THF)

[jammin]

https://www.thevespiary.org/rhodium/Rhodium/chemistry/amphetamine.html

Is it possible to recycle thesolvents in this particular synth?

Im mainly thinking about the THF, but any info would be greatly appriciated.

[eXcidium]

That a good questions to ask, I wondered the same...

Tough if you managed to recycle it, you'll have to stabilize it with BHT (2,6-Bis(1,1-dimethylethyl)-4-methylphenol)

Cheers

[eXcidium]

Also, in the final step, it mentions :

The pooled organic extracts was dried over MgSO4, filtered and the solvent evaporated under vacuum.

Would someone be able to distill off the DCM, instead of evaporating it?

Thanks anyone

[Rhodium]

In regards to the recycling of THF, you might want to read this document:

Recovery of Tetrahydrofuran (THF)

(https://www.thevespiary.org/rhodium/Rhodium/pdf/thfrecovery.pdf)

You need to dry the THF fully, preferably by refluxing over sodium/benzophenone, but after the pre-drying outlined in the above document, it may be enough to reflux with molecular sieves or sodium/potassium hydroxide followed by distillation from a fresh batch of KOH/NaOH.

Would someone be able to distill off the DCM, instead of evaporating it?

Of course - distillation is evaporation, additionally followed by condensation of the vapors. From the perspective of the product it couldn't make less of a difference if the vapors was allowed to escape into the atmosphere, if they were condensed in a distillation reciever or even if you huffed them - it's all evaporation to begin with.