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Author Topic: increasing reduction yields by dehydration  (Read 84 times)

akcom

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increasing reduction yields by dehydration
« on: August 07, 2010, 08:20:23 PM »
When performing a reduction of MDP2P + methylamine, could one obtain a significant increase in yield by forming the imine first in the presence of a dehydrating agent like a mol sieve or silica beads?  Or does it not matter since the imine is being reduced immediately anyway, thus pushing the equilibrium towards imine formation?

mumbles

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Re: increasing reduction yields by dehydration
« Reply #1 on: August 09, 2010, 05:27:01 AM »
Silica gel has very large pores, they might just suck up your solvent as readily as water. I think the reaction requires a little water be present.
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